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TABLE 1

Basal 5-h fasted data

BL6129FVBDBA
Body weight (g) 22.1 ± 0.3* 21.2 ± 0.3 24.2 ± 0.3 22.5 ± 0.5 
Muscle mass (% body wt) 77 ± 1*§ 72 ± 1 73 ± 1 70 ± 1 
Fat mass (% body wt) 9 ± 1*§ 13 ± 1 14 ± 1 18 ± 1 
Whole-blood glucose (mmol/l) 9.1 ± 0.2§ 7.1 ± 0.2 9.1 ± 0.3 7.8 ± 0.2 
Plasma glucose (mmol/l) 9.7 ± 0.4§ 8.6 ± 0.3 9.2 ± 0.1 8.8 ± 0.1 
Blood glucose:plasma glucose 0.96 ± 0.04 0.84 ± 0.01 0.95 ± 0.02 0.90 ± 0.02 
Insulin (pmol/l) 138 ± 24§ 90 ± 12 114 ± 18 198 ± 12 
C-peptide (nmol/l) 0.59 ± 0.06* 0.59 ± 0.06 0.36 ± 0.06 0.46 ± 0.06 
Glucagon (ng/l) 61 ± 7*‡ 48 ± 3 39 ± 3 60 ± 6 
Corticosterone (ng/l) 0.17 ± 0.02 0.23 ± 0.04 0.25 ± 0.05 0.17 ± 0.02 
Epinephrine (pmol/l) 300 ± 55* <109† 775 ± 175 257 ± 44 
Norepinephrine (nmol/l) 0.92 ± 0.14*§ 0.89 ± 0.08 1.24 ± 0.11 1.27 ± 0.19 
Glucose endoRa(mmol · kg−1 · min−10.10 ± 0.01 0.10 ± 0.01 0.12 ± 0.01 0.12 ± 0.01 
Glucose Rd(mmol · kg−1 · min−10.11 ± 0.01 0.11 ± 0.01 0.12 ± 0.01 0.12 ± 0.01 
Fasting plasma glucose–to–insulin ratio 100 ± 11§ 107 ± 13 105 ± 18 44 ± 3.6 
HOMA-IR 11.4 ± 1.7 4.9 ± 0.5 7.7 ± 1.1 11.5 ± 0.9 
QUICKI 0.47 ± 0.02* 0.31 ± 0.01 0.30 ± 0.01 0.34 ± 0.07 
BL6129FVBDBA
Body weight (g) 22.1 ± 0.3* 21.2 ± 0.3 24.2 ± 0.3 22.5 ± 0.5 
Muscle mass (% body wt) 77 ± 1*§ 72 ± 1 73 ± 1 70 ± 1 
Fat mass (% body wt) 9 ± 1*§ 13 ± 1 14 ± 1 18 ± 1 
Whole-blood glucose (mmol/l) 9.1 ± 0.2§ 7.1 ± 0.2 9.1 ± 0.3 7.8 ± 0.2 
Plasma glucose (mmol/l) 9.7 ± 0.4§ 8.6 ± 0.3 9.2 ± 0.1 8.8 ± 0.1 
Blood glucose:plasma glucose 0.96 ± 0.04 0.84 ± 0.01 0.95 ± 0.02 0.90 ± 0.02 
Insulin (pmol/l) 138 ± 24§ 90 ± 12 114 ± 18 198 ± 12 
C-peptide (nmol/l) 0.59 ± 0.06* 0.59 ± 0.06 0.36 ± 0.06 0.46 ± 0.06 
Glucagon (ng/l) 61 ± 7*‡ 48 ± 3 39 ± 3 60 ± 6 
Corticosterone (ng/l) 0.17 ± 0.02 0.23 ± 0.04 0.25 ± 0.05 0.17 ± 0.02 
Epinephrine (pmol/l) 300 ± 55* <109† 775 ± 175 257 ± 44 
Norepinephrine (nmol/l) 0.92 ± 0.14*§ 0.89 ± 0.08 1.24 ± 0.11 1.27 ± 0.19 
Glucose endoRa(mmol · kg−1 · min−10.10 ± 0.01 0.10 ± 0.01 0.12 ± 0.01 0.12 ± 0.01 
Glucose Rd(mmol · kg−1 · min−10.11 ± 0.01 0.11 ± 0.01 0.12 ± 0.01 0.12 ± 0.01 
Fasting plasma glucose–to–insulin ratio 100 ± 11§ 107 ± 13 105 ± 18 44 ± 3.6 
HOMA-IR 11.4 ± 1.7 4.9 ± 0.5 7.7 ± 1.1 11.5 ± 0.9 
QUICKI 0.47 ± 0.02* 0.31 ± 0.01 0.30 ± 0.01 0.34 ± 0.07 

Data are means ± SE. Data from 12-week-old, 5-h-fasted C57BL/6J (BL6), 129X1/SvJ (129), FVB/NJ (FVB), and DBA/2J (DBA) male mice. Body weight, blood glucose, insulin, fasting glucose–to–insulin ratio, HOMA-IR, and QUICKI were compiled from basal samples during hyperinsulinemic-euglycemic (euglycemic), insulin-induced hypoglycemic (hypoglycemic), and hyperglycemic clamp experiments in chronically catheterized, conscious mice (n = 27 for BL6; 25 for 129; 22 for FVB; and 24 for DBA mice). QUICKI and HOMA-IR were calculated using equations described in research design and methods. Epinephrine and norepineprhine were measured before hypoglycemic and hyperglycemic clamps (n = 19 for BL6; 18 for 129; 15 for FVB; and 14 for DBA mice). Muscle mass, fat mass, glucagon, and corticosterone were measured before hypoglycemic clamps (n = 8 for BL6; 7 for 129; 7 for FVB; and 7 for DBA mice). EndoRa, Rd, and plasma glucose were determined from euglycemic clamp data (n = 8 for BL6; 9 for 129; 7 for FVB; and 10 for DBA mice). Comparisons are

*

BL6 vs. FVB,

129 vs. FVB,

BL6 vs. 129,

§

BL6 vs. DBA,

129 vs. DBA, and

FVB vs. DBA, where statistical significance is established at P < 0.05.

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