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TABLE 2

Hyperinsulinemic-euglycemic clamp data

BL6129FVBDBA
GIR (mmol · kg−1 · min−10.30 ± 0.01* 0.37 ± 0.02 0.32 ± 0.02 0.26 ± 0.01 
Insulin (pmol · l−1338 ± 29§ 420 ± 37 360 ± 34 472 ± 59 
ΔInsulinClamp-Basal (pmol · l−1230 ± 26 305 ± 45 211 ± 17 282 ± 47 
GIR/insulin (mmol · l−1 · [kg · min−1 · pmol−1]−1) × 10−4 9.4 ± 0.8§ 9.2 ± 0.8 9.4 ± 1.2 6.4 ± 0.9 
GIR/ΔinsulinClamp-Basal (mmol · l−1 · [kg · min−1 · pmol−1]−1) × 10−4 14.5 ± 1.9 14.9 ± 2.6 15.5 ± 1.4 15.4 ± 4.6 
EndoRa (mmol · kg−1 · min−1−0.03 ± 0.01 −0.03 ± 0.02 0.02 ± 0.01 −0.02 ± 0.01 
Rd(mmol · kg−1 · min−10.27 ± 0.01*§ 0.33 ± 0.02 0.34 ± 0.02 0.24 ± 0.01 
Rd/insulin (mmol · L−1 · [kg · min−1 · pmol−1]−1) × 10−4 8.4 ± 0.7§ 8.3 ± 0.7 10.2 ± 0.5 5.5 ± 0.8 
ΔInsulinClamp-Basal/insulin infusion (kg · min · L−19.6 ± 1.1 12.7 ± 1.9 8.8 ± 0.7 10.6 ± 2.3 
BL6129FVBDBA
GIR (mmol · kg−1 · min−10.30 ± 0.01* 0.37 ± 0.02 0.32 ± 0.02 0.26 ± 0.01 
Insulin (pmol · l−1338 ± 29§ 420 ± 37 360 ± 34 472 ± 59 
ΔInsulinClamp-Basal (pmol · l−1230 ± 26 305 ± 45 211 ± 17 282 ± 47 
GIR/insulin (mmol · l−1 · [kg · min−1 · pmol−1]−1) × 10−4 9.4 ± 0.8§ 9.2 ± 0.8 9.4 ± 1.2 6.4 ± 0.9 
GIR/ΔinsulinClamp-Basal (mmol · l−1 · [kg · min−1 · pmol−1]−1) × 10−4 14.5 ± 1.9 14.9 ± 2.6 15.5 ± 1.4 15.4 ± 4.6 
EndoRa (mmol · kg−1 · min−1−0.03 ± 0.01 −0.03 ± 0.02 0.02 ± 0.01 −0.02 ± 0.01 
Rd(mmol · kg−1 · min−10.27 ± 0.01*§ 0.33 ± 0.02 0.34 ± 0.02 0.24 ± 0.01 
Rd/insulin (mmol · L−1 · [kg · min−1 · pmol−1]−1) × 10−4 8.4 ± 0.7§ 8.3 ± 0.7 10.2 ± 0.5 5.5 ± 0.8 
ΔInsulinClamp-Basal/insulin infusion (kg · min · L−19.6 ± 1.1 12.7 ± 1.9 8.8 ± 0.7 10.6 ± 2.3 

Data are means ± SE. Steady-state data during 120-min hyperinsulinemic-euglycemic clamp experiments (24 pmol · kg−1 · min−1 insulin) in chronically catheterized, conscious, 5-h-fasted C57BL/6 (BL6; n = 8), 129X1/Sv (129; n = 9), FVB/N (FVB; n = 7), and DBA/2 (DBA; n = 10) male 12 week-old mice. EndoRa and Rdare determined as described in research design and methods. ΔInsulin Clamp-Basal/insulin infusion is an assessment of insulin clearance. Steady-state values are the mean of five samples taken every 10 min from t = 80–120 min. Comparisons are

*

BL6 vs. 129,

129 vs. FVB,

129 vs. DBA,

§

BL6 vs. DBA,

FVB vs. DBA, and

BL6 vs. FVB, where statistical significance is established at P < 0.05.

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