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TABLE 3

Pancreatic islet mass in four mouse strains

BL6129FVBDBA
Pancreatic insulin content (nmol/g pancreas) 25.8 ± 3.1* 10.2 ± 1.4 17.2 ± 0.9 13.7 ± 1.2 
Insulin content in isolated islets (pmol/islet equivalent) 10.6 ± 0.5* 7.9 ± 0.6 11.9 ± 0.3 7.9 ± 0.3 
Total islet mass (mg) 2.5 ± 0.3 1.8 ± 0.1 2.8 ± 0.4 3.4 ± 0.2 
β-Cell mass (mg) 2.3 ± 0.3 1.5 ± 0.1 2.6 ± 0.4 3.0 ± 0.2 
α-Cell mass (mg) 0.20 ± 0.04 0.23 ± 0.03 0.18 ± 0.03 0.38 ± 0.05 
BL6129FVBDBA
Pancreatic insulin content (nmol/g pancreas) 25.8 ± 3.1* 10.2 ± 1.4 17.2 ± 0.9 13.7 ± 1.2 
Insulin content in isolated islets (pmol/islet equivalent) 10.6 ± 0.5* 7.9 ± 0.6 11.9 ± 0.3 7.9 ± 0.3 
Total islet mass (mg) 2.5 ± 0.3 1.8 ± 0.1 2.8 ± 0.4 3.4 ± 0.2 
β-Cell mass (mg) 2.3 ± 0.3 1.5 ± 0.1 2.6 ± 0.4 3.0 ± 0.2 
α-Cell mass (mg) 0.20 ± 0.04 0.23 ± 0.03 0.18 ± 0.03 0.38 ± 0.05 

Data are means ± SE. Total pancreatic insulin content, islet insulin content in isolated islets (normalized for size [islet equivalent]), total islet mass, β-cell mass, and α-cell mass from 12-week-old male C57BL/6 (BL6), 129X1/Sv (129), FVB/N (FVB), and DBA/2 (DBA) mice (n = 4–6 mice/group). Comparisons are

*

BL6 vs. 129,

BL6 vs. FVB,

129 vs. DBA, and

§ FVB vs. DBA, where statistical significance is established at P < 0.05.

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