American Diabetes Association

TABLE 1

Association of IGF2BP2 SNPs with type 2 diabetes: confirmed susceptibility SNPs rs4402960 and rs1470579 and SNPs showing nominal association (P < 0.05) in French Caucasians

SNP	Chr. Position (bp) NCBI36	Gene region^*	Allele	Allele count			P	OR (95% CI)
SNP	Chr. Position (bp) NCBI36	Gene region^*	Allele				P	OR (95% CI)	Type 2 diabetic case subjects (%)	Normoglycemic control subjects (%)
rs9826022	186,839,954	3′ downstream	A	2,532 (93.0)	2,949 (95.3)	0.0002	1.53 (1.22–1.91)
		(+4267 bp)	G	190 (7.0)	145 (4.7)
rs9864104	186,840,225	3′ downstream	C	2,260 (81.7)	2,628 (84.2)	0.012	1.19 (1.04–1.37)
		(+3996 bp)	T	506 (18.3)	494 (15.8)
rs4402960	186,994,381	Intron 6	G	1,786 (67.5)	2,111 (68.1)	0.632	1.03 (0.92–1.15)
			T	858 (32.5)	987 (31.9)
rs1470579	187,011,773	Intron 5	A	1,753 (67.3)	2,120 (67.4)	0.896	1.01 (0.90–1.13)
			C	853 (32.7)	1,024 (32.6)

SNP	Chr. Position (bp) NCBI36	Gene region^*	Allele	Allele count			P	OR (95% CI)
SNP	Chr. Position (bp) NCBI36	Gene region^*	Allele				P	OR (95% CI)	Type 2 diabetic case subjects (%)	Normoglycemic control subjects (%)
rs9826022	186,839,954	3′ downstream	A	2,532 (93.0)	2,949 (95.3)	0.0002	1.53 (1.22–1.91)
		(+4267 bp)	G	190 (7.0)	145 (4.7)
rs9864104	186,840,225	3′ downstream	C	2,260 (81.7)	2,628 (84.2)	0.012	1.19 (1.04–1.37)
		(+3996 bp)	T	506 (18.3)	494 (15.8)
rs4402960	186,994,381	Intron 6	G	1,786 (67.5)	2,111 (68.1)	0.632	1.03 (0.92–1.15)
			T	858 (32.5)	987 (31.9)
rs1470579	187,011,773	Intron 5	A	1,753 (67.3)	2,120 (67.4)	0.896	1.01 (0.90–1.13)
			C	853 (32.7)	1,024 (32.6)

Data are n (%) unless otherwise indicated.

Relative to the NCBI36 coordinates of the IGF2BP2 genomic locus (chr. 3:186,844,221.0.187,025,521). χ² P values are shown.

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