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TABLE 1

Association of IGF2BP2 SNPs with type 2 diabetes: confirmed susceptibility SNPs rs4402960 and rs1470579 and SNPs showing nominal association (P < 0.05) in French Caucasians

SNPChr. Position (bp) NCBI36Gene region*AlleleAllele count
POR (95% CI)
Type 2 diabetic case subjects (%)Normoglycemic control subjects (%)
rs9826022 186,839,954 3′ downstream 2,532 (93.0) 2,949 (95.3) 0.0002 1.53 (1.22–1.91) 
  (+4267 bp) 190 (7.0) 145 (4.7)   
rs9864104 186,840,225 3′ downstream 2,260 (81.7) 2,628 (84.2) 0.012 1.19 (1.04–1.37) 
  (+3996 bp) 506 (18.3) 494 (15.8)   
rs4402960 186,994,381 Intron 6 1,786 (67.5) 2,111 (68.1) 0.632 1.03 (0.92–1.15) 
   858 (32.5) 987 (31.9)   
rs1470579 187,011,773 Intron 5 1,753 (67.3) 2,120 (67.4) 0.896 1.01 (0.90–1.13) 
   853 (32.7) 1,024 (32.6)   
SNPChr. Position (bp) NCBI36Gene region*AlleleAllele count
POR (95% CI)
Type 2 diabetic case subjects (%)Normoglycemic control subjects (%)
rs9826022 186,839,954 3′ downstream 2,532 (93.0) 2,949 (95.3) 0.0002 1.53 (1.22–1.91) 
  (+4267 bp) 190 (7.0) 145 (4.7)   
rs9864104 186,840,225 3′ downstream 2,260 (81.7) 2,628 (84.2) 0.012 1.19 (1.04–1.37) 
  (+3996 bp) 506 (18.3) 494 (15.8)   
rs4402960 186,994,381 Intron 6 1,786 (67.5) 2,111 (68.1) 0.632 1.03 (0.92–1.15) 
   858 (32.5) 987 (31.9)   
rs1470579 187,011,773 Intron 5 1,753 (67.3) 2,120 (67.4) 0.896 1.01 (0.90–1.13) 
   853 (32.7) 1,024 (32.6)   

Data are n (%) unless otherwise indicated.

*

Relative to the NCBI36 coordinates of the IGF2BP2 genomic locus (chr. 3:186,844,221.0.187,025,521). χ2P values are shown.

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