Subject characteristics
| . | BetaGene . | . | . | . | IRASFS . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | Probands . | Siblings . | Cousins . | All . | San Antonio . | San Luis Valley . | ||||
| n | 71 | 231 | 171 | 473 | 490 | 496 | ||||
| Men/women | 0/71 | 84/147 | 79/92 | 163/310 | 191/299 | 213/283 | ||||
| Age (years) | 34.7 (7.8) | 33.8 (10.5) | 32.7 (11.8) | 33.8 (10.6) | 38.8 (20.1) | 40.0 (16.8) | ||||
| BMI (kg/m2) | 31.3 (8.7) | 29.0 (6.4)* | 27.4 (6.4)*† | 28.8 (7.0) | 28.7 (8.2) | 26.4 (6.8)‡ | ||||
| Fasting glucose (mmol/l) | 5.4 (0.9) | 5.1 (0.6)* | 5.1 (0.6)* | 5.2 (0.6) | 5.1 (0.7) | 5.1 (0.6)‡ | ||||
| 2-h glucose (mmol/l) | 8.4 (3.5) | 7.3 (2.5)* | 6.4 (2.2)*† | 7.2 (2.6) | — | — | ||||
| Fasting insulin (pmol/l) | 76 (62) | 49 (49)* | 42 (42)* | 49 (56) | 78 (72) | 66 (60)‡ | ||||
| 2-h insulin (pmol/l) | 660 (556) | 431 (437)* | 333 (403)* | 424 (465) | — | — | ||||
| 30′ Δinsulin (pmol/l) | 431 (285) | 379 (295) | 410 (410) | 399 (319) | — | — | ||||
| SG (×10−2 min−1) | 1.29 (0.42) | 1.55 (0.71)* | 1.74 (0.77)* | 1.53 (0.74) | 1.86 (1.00) | 2.24 (1.02)‡ | ||||
| SI (×10−3 min−1 per pmol/l) | 2.17 (1.24) | 2.62 (1.94) | 2.94 (1.95) | 2.65 (1.77) | 2.47 (2.92) | 3.17 (3.83) | ||||
| AIR (pmol/l × 10 min) | 3,467 (4,313) | 4,280 (4,677)* | 4,783 (6,050)* | 4,340 (5,070) | 5,506 (5,945) | 6,262 (6,475)‡ | ||||
| Disposition index | 7,890 (7,799) | 11,401 (11,458)* | 13,249 (10,654)* | 11,409 (11,225) | 14,315 (18,101) | 19,898 (26,954)‡ | ||||
| . | BetaGene . | . | . | . | IRASFS . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | Probands . | Siblings . | Cousins . | All . | San Antonio . | San Luis Valley . | ||||
| n | 71 | 231 | 171 | 473 | 490 | 496 | ||||
| Men/women | 0/71 | 84/147 | 79/92 | 163/310 | 191/299 | 213/283 | ||||
| Age (years) | 34.7 (7.8) | 33.8 (10.5) | 32.7 (11.8) | 33.8 (10.6) | 38.8 (20.1) | 40.0 (16.8) | ||||
| BMI (kg/m2) | 31.3 (8.7) | 29.0 (6.4)* | 27.4 (6.4)*† | 28.8 (7.0) | 28.7 (8.2) | 26.4 (6.8)‡ | ||||
| Fasting glucose (mmol/l) | 5.4 (0.9) | 5.1 (0.6)* | 5.1 (0.6)* | 5.2 (0.6) | 5.1 (0.7) | 5.1 (0.6)‡ | ||||
| 2-h glucose (mmol/l) | 8.4 (3.5) | 7.3 (2.5)* | 6.4 (2.2)*† | 7.2 (2.6) | — | — | ||||
| Fasting insulin (pmol/l) | 76 (62) | 49 (49)* | 42 (42)* | 49 (56) | 78 (72) | 66 (60)‡ | ||||
| 2-h insulin (pmol/l) | 660 (556) | 431 (437)* | 333 (403)* | 424 (465) | — | — | ||||
| 30′ Δinsulin (pmol/l) | 431 (285) | 379 (295) | 410 (410) | 399 (319) | — | — | ||||
| SG (×10−2 min−1) | 1.29 (0.42) | 1.55 (0.71)* | 1.74 (0.77)* | 1.53 (0.74) | 1.86 (1.00) | 2.24 (1.02)‡ | ||||
| SI (×10−3 min−1 per pmol/l) | 2.17 (1.24) | 2.62 (1.94) | 2.94 (1.95) | 2.65 (1.77) | 2.47 (2.92) | 3.17 (3.83) | ||||
| AIR (pmol/l × 10 min) | 3,467 (4,313) | 4,280 (4,677)* | 4,783 (6,050)* | 4,340 (5,070) | 5,506 (5,945) | 6,262 (6,475)‡ | ||||
| Disposition index | 7,890 (7,799) | 11,401 (11,458)* | 13,249 (10,654)* | 11,409 (11,225) | 14,315 (18,101) | 19,898 (26,954)‡ | ||||
Data are median (interquartile range).
Uncorrected P < 0.05 vs. probands after adjusting for age, sex, and BMI (where appropriate).
Uncorrected P < 0.05 vs. siblings after adjusting for age, sex, and BMI (where appropriate).
Uncorrected P < 0.05 vs. San Antonio after adjusting for age, sex, and BMI (where appropriate).