American Diabetes Association

TABLE 4

S_I association with interaction between PPARG2 and HNF4A among IRASFS subjects

	PPARG2 Pro12Ala genotype
		Ala/Pro or Ala/Ala					Pro/Pro
		HNF4A rs2144908 genotype
		A/A	A/G	G/G	A/A	A/G	G/G	Additive^*	Recessive^*
San Antonio
n	32	63	23	75	187	104
	3.65 (1.94)	3.15 (1.57)	2.45 (1.33)	2.71 (1.43)	2.58 (1.21)	2.42 (1.45)	0.056	0.018
San Luis Valley
n	19	44	25	85	214	109
	3.18 (1.69)	3.74 (1.74)	3.99 (2.04)	3.22 (1.58)	3.30 (1.69)	3.26 (1.73)	0.401	0.176

	PPARG2 Pro12Ala genotype
		Ala/Pro or Ala/Ala					Pro/Pro
		HNF4A rs2144908 genotype
		A/A	A/G	G/G	A/A	A/G	G/G	Additive^*	Recessive^*
San Antonio
n	32	63	23	75	187	104
	3.65 (1.94)	3.15 (1.57)	2.45 (1.33)	2.71 (1.43)	2.58 (1.21)	2.42 (1.45)	0.056	0.018
San Luis Valley
n	19	44	25	85	214	109
	3.18 (1.69)	3.74 (1.74)	3.99 (2.04)	3.22 (1.58)	3.30 (1.69)	3.26 (1.73)	0.401	0.176

Genotype-specific trait values are shown as mean (SD) adjusted for age, sex, and BMI.

Genetic model assumed for HNF4A rs2144908 in the interaction with PPARG2. PPARG2 Pro12Ala was assumed to follow a dominant genetic model for Ala.

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