Skip to Main Content
TABLE 1

Fat pad mass, tissue triglyceride levels, and metabolic parameters from hyperinsulinemic-euglycemic clamps in rats

ControlHFDHFD dhBBR
Body mass (g) 349 ± 7 367 ± 5* 361 ± 6 
Epididymal fat pad (%) 1.05 ± 0.04 1.94 ± 0.11 1.48 ± 0.10§ 
Inguinal fat pad (%) 1.04 ± 0.07 2.28 ± 0.16 1.79 ± 0.11§ 
Muscle triglyceride (μmol/g) 3.0 ± 0.3 5.1 ± 1.0* 3.1 ± 0.2 
Liver triglyceride (μmol/g) 4.8 ± 0.2 17.1 ± 1.9 9.4 ± 1.4* 
Glucose infusion rate (mg · kg−1 · min−140.2 ± 2.2 19.0 ± 0.4 27.4 ± 1.9§ 
Rd (mg · kg−1 · min−138.4 ± 1.9 23.2 ± 0.5 30.3 ± 0.6§ 
Hepatic glucose output (mg · kg−1 · min−1−1.7 ± 0.5 4.2 ± 0.6 2.8 ± 1.7 
Rg′: red gastrocnemius 35.6 ± 3.3 19.8 ± 1.7 34.9 ± 7.9 
Rg′: white gastrocnemius 15.2 ± 2.7 5.7 ± 0.7 8.5 ± 1.5* 
Rg′: epididymal fat 1.8 ± 0.2 1.3 ± 0.1 2.1 ± 0.4 
ControlHFDHFD dhBBR
Body mass (g) 349 ± 7 367 ± 5* 361 ± 6 
Epididymal fat pad (%) 1.05 ± 0.04 1.94 ± 0.11 1.48 ± 0.10§ 
Inguinal fat pad (%) 1.04 ± 0.07 2.28 ± 0.16 1.79 ± 0.11§ 
Muscle triglyceride (μmol/g) 3.0 ± 0.3 5.1 ± 1.0* 3.1 ± 0.2 
Liver triglyceride (μmol/g) 4.8 ± 0.2 17.1 ± 1.9 9.4 ± 1.4* 
Glucose infusion rate (mg · kg−1 · min−140.2 ± 2.2 19.0 ± 0.4 27.4 ± 1.9§ 
Rd (mg · kg−1 · min−138.4 ± 1.9 23.2 ± 0.5 30.3 ± 0.6§ 
Hepatic glucose output (mg · kg−1 · min−1−1.7 ± 0.5 4.2 ± 0.6 2.8 ± 1.7 
Rg′: red gastrocnemius 35.6 ± 3.3 19.8 ± 1.7 34.9 ± 7.9 
Rg′: white gastrocnemius 15.2 ± 2.7 5.7 ± 0.7 8.5 ± 1.5* 
Rg′: epididymal fat 1.8 ± 0.2 1.3 ± 0.1 2.1 ± 0.4 

Data are means ± SE (n = 5–12 per group). dhBBR was provided in the HFD (100 mg · kg−1 · day−1) for the final 2 weeks of high-fat feeding. Fat pad weights are expressed as a percentage of body mass. Plasma levels of glucose and insulin were similar among the three groups during the clamp (data not shown). Rg′, insulin-stimulated glucose uptake during the clamp (μmol/100 g · min).

*

P < 0.05,

P < 0.01 vs. control;

P < 0.05,

§

P < 0.01 vs. HFD.

Close Modal

or Create an Account

Close Modal
Close Modal