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TABLE 2

Results for the mean A1C in either the conventional, intensive, or combined treatment groups (stage 1) for any SNP with P < 10−6

ChromosomeSNPPositionMean A1C PCommon homozygote
Heterozygote
Rare homozygote
A1A2Minor allele frequencyMissing data*Hardy-Weinberg equilibrium PLocation of SNP to the nearest gene
nMean ± SDnMean ± SDnMean ± SD
Conventional treatment group                
    9 rs10810632 16,779,024 3.7 × 10−7 576 8.96 ± 1.22 85 9.63 ± 1.22 10.63 ± 1.35 0.079 0.70 Intron 1 BNC2 
    9 rs6475082 16,779,436 7.4 × 10−7 575 8.96 ± 1.22 86 9.61 ± 1.23 10.63 ± 1.35 0.079 0.71 Intron 1 BNC2 
    9 rs4961760 16,779,878 7.1 × 10−7 575 8.96 ± 1.22 87 9.61 ± 1.22 10.63 ± 1.35 0.080 0.71 Intron 1 BNC2 
    10 rs1358030 108,113,589 5.4 × 10−9 268 8.71 ± 1.15 307 9.24 ± 1.25 90 9.44 ± 1.24 0.361 0.12 3′ SORCS1 
    18 rs163061 22,727,740 9.7 × 10−7 350 8.83 ± 1.17 259 9.29 ± 1.26 35 9.62 ± 1.43 0.262 40 0.34 3′ C18orf16 
Intensive treatment group                
    15 rs493218 51,277,554 5.4 × 10−7 506 7.31 ± 0.96 120 7.01 ± 0.89 11 6.38 ± 0.69 0.109 0.20 3′ WDR72 
    15 rs572221 51,291,924 6.8 × 10−7 504 7.31 ± 0.96 120 7.01 ± 0.89 11 6.38 ± 0.69 0.110 0.25 3′ WDR72 
    15 rs690271 51,291,964 5.1 × 10−7 505 7.31 ± 0.96 121 7.01 ± 0.88 11 6.38 ± 0.69 0.110 0.26 3′ WDR72 
    15 rs566369 51,295,884 5.1 × 10−7 505 7.31 ± 0.96 121 7.01 ± 0.88 11 6.38 ± 0.69 0.110 0.26 3′ WDR72 
    15 rs482541 51,296,486 5.1 × 10−7 505 7.31 ± 0.96 121 7.01 ± 0.88 11 6.38 ± 0.69 0.110 0.26 3′ WDR72 
Combined treatment groups                
    5 rs286405 35,613,014 6.7 × 10−7 421 7.99 ± 1.32 631 8.18 ± 1.48 233 8.55 ± 1.68 0.427 19 0.95 5′ FLJ23577 
    10 rs1358030 108,113,589 2.2 × 10−9 545 7.93 ± 1.32 574 8.35 ± 1.57 183 8.48 ± 1.53 0.361 0.12 3′ SORCS1 
ChromosomeSNPPositionMean A1C PCommon homozygote
Heterozygote
Rare homozygote
A1A2Minor allele frequencyMissing data*Hardy-Weinberg equilibrium PLocation of SNP to the nearest gene
nMean ± SDnMean ± SDnMean ± SD
Conventional treatment group                
    9 rs10810632 16,779,024 3.7 × 10−7 576 8.96 ± 1.22 85 9.63 ± 1.22 10.63 ± 1.35 0.079 0.70 Intron 1 BNC2 
    9 rs6475082 16,779,436 7.4 × 10−7 575 8.96 ± 1.22 86 9.61 ± 1.23 10.63 ± 1.35 0.079 0.71 Intron 1 BNC2 
    9 rs4961760 16,779,878 7.1 × 10−7 575 8.96 ± 1.22 87 9.61 ± 1.22 10.63 ± 1.35 0.080 0.71 Intron 1 BNC2 
    10 rs1358030 108,113,589 5.4 × 10−9 268 8.71 ± 1.15 307 9.24 ± 1.25 90 9.44 ± 1.24 0.361 0.12 3′ SORCS1 
    18 rs163061 22,727,740 9.7 × 10−7 350 8.83 ± 1.17 259 9.29 ± 1.26 35 9.62 ± 1.43 0.262 40 0.34 3′ C18orf16 
Intensive treatment group                
    15 rs493218 51,277,554 5.4 × 10−7 506 7.31 ± 0.96 120 7.01 ± 0.89 11 6.38 ± 0.69 0.109 0.20 3′ WDR72 
    15 rs572221 51,291,924 6.8 × 10−7 504 7.31 ± 0.96 120 7.01 ± 0.89 11 6.38 ± 0.69 0.110 0.25 3′ WDR72 
    15 rs690271 51,291,964 5.1 × 10−7 505 7.31 ± 0.96 121 7.01 ± 0.88 11 6.38 ± 0.69 0.110 0.26 3′ WDR72 
    15 rs566369 51,295,884 5.1 × 10−7 505 7.31 ± 0.96 121 7.01 ± 0.88 11 6.38 ± 0.69 0.110 0.26 3′ WDR72 
    15 rs482541 51,296,486 5.1 × 10−7 505 7.31 ± 0.96 121 7.01 ± 0.88 11 6.38 ± 0.69 0.110 0.26 3′ WDR72 
Combined treatment groups                
    5 rs286405 35,613,014 6.7 × 10−7 421 7.99 ± 1.32 631 8.18 ± 1.48 233 8.55 ± 1.68 0.427 19 0.95 5′ FLJ23577 
    10 rs1358030 108,113,589 2.2 × 10−9 545 7.93 ± 1.32 574 8.35 ± 1.57 183 8.48 ± 1.53 0.361 0.12 3′ SORCS1 

A1C values are %. Mean = mean A1C value, SD = standard deviation of A1C values. A1 = minor, A2 = major allele.

*Number of individuals with missing genotype data. Asymptotic P values from the 2df normal score test. Position is the nucleotide location from build 36.3.

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