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TABLE 4

Loci for which there is evidence for association using repeated A1C values (stages 3 and 4)

ChromosomeSNPPositionStage 2: repeated A1C P
Stage 3: repeated daily glucose P
Stage 3: mean glucose by genotype (mg/dl)
Stage 4: repeated A1C P value (COMB = CON +INT)
CONINTCONINTCOMBC homo (SE)Het (SE)R homo (SE)SNP PSNP treatment interaction
rs10810632 16,779,024 9.0 × 10−8 0.44 9.7 × 10−3 0.62 0.52 216 (2)* 226 (5)* 259 (25)* 9.2 × 10−3 7.9 × 10−4 
rs6475082 16,779,436 1.8 × 10−7 0.44 0.011 0.62 0.52 216 (2)* 225 (5)* 259 (25)* 0.011 1.1 × 10−3 
rs4961760 16,779,878 1.6 × 10−7 0.44 0.012 0.62 0.53 216 (2)* 225 (5)* 259 (25)* 0.010 1.1 × 10−3 
rs2254193 16,791,850 2.0 × 10−7 0.67 8.3 × 10−3 0.50 0.34 216 (2)* 229 (6)* 253 (27)* 0.011 3.1 × 10−3 
10 rs1358030 108,113,589 6.9 × 10−10 0.012 2.7 × 10−5 5.8 × 10−3 1.5 × 10−6 208 (3)* 223 (3)* 228 (5)* 3.8 × 10−10 0.013 
14 rs11624318 94,375,765 9.4 × 10−4 2.9 × 10−3 0.40 0.035 0.025 180 (1) 182 (2) 170 (4) 2.7 × 10−7 0.95 
14 rs11160219 94,405,244 1.1 × 10−5 0.023 0.37 0.58 0.49 181 (1) 180 (2) 176 (4) 4.3 × 10−7 0.25 
14 rs8007115 94,407,241 2.2 × 10−5 0.017 0.38 0.78 0.49 181 (1) 180 (2) 176 (4) 5.4 × 10−7 0.37 
15 rs493218 51,277,554 0.77 5.2 × 10−7 0.32 0.10 0.074 149 (1) 145 (2) 142 (7) 8.9 × 10−3 2.4 × 10−4 
15 rs572221 51,291,924 0.83 6.6 × 10−7 0.26 0.088 0.056 149 (1) 145 (2) 142 (7) 8.3 × 10−3 3.6 × 10−4 
15 rs690271 51,291,964 0.83 5.0 × 10−7 0.26 0.085 0.050 149 (1) 145 (2) 142 (7) 7.6 × 10−3 3.4 × 10−4 
15 rs566369 51,295,884 0.82 5.0 × 10−7 0.26 0.085 0.050 149 (1) 145 (2) 142 (7) 7.6 × 10−3 3.4 × 10−4 
15 rs482541 51,296,486 0.82 5.0 × 10−7 0.26 0.085 0.050 149 (1) 145 (2) 142 (7) 7.6 × 10−3 3.4 × 10−4 
ChromosomeSNPPositionStage 2: repeated A1C P
Stage 3: repeated daily glucose P
Stage 3: mean glucose by genotype (mg/dl)
Stage 4: repeated A1C P value (COMB = CON +INT)
CONINTCONINTCOMBC homo (SE)Het (SE)R homo (SE)SNP PSNP treatment interaction
rs10810632 16,779,024 9.0 × 10−8 0.44 9.7 × 10−3 0.62 0.52 216 (2)* 226 (5)* 259 (25)* 9.2 × 10−3 7.9 × 10−4 
rs6475082 16,779,436 1.8 × 10−7 0.44 0.011 0.62 0.52 216 (2)* 225 (5)* 259 (25)* 0.011 1.1 × 10−3 
rs4961760 16,779,878 1.6 × 10−7 0.44 0.012 0.62 0.53 216 (2)* 225 (5)* 259 (25)* 0.010 1.1 × 10−3 
rs2254193 16,791,850 2.0 × 10−7 0.67 8.3 × 10−3 0.50 0.34 216 (2)* 229 (6)* 253 (27)* 0.011 3.1 × 10−3 
10 rs1358030 108,113,589 6.9 × 10−10 0.012 2.7 × 10−5 5.8 × 10−3 1.5 × 10−6 208 (3)* 223 (3)* 228 (5)* 3.8 × 10−10 0.013 
14 rs11624318 94,375,765 9.4 × 10−4 2.9 × 10−3 0.40 0.035 0.025 180 (1) 182 (2) 170 (4) 2.7 × 10−7 0.95 
14 rs11160219 94,405,244 1.1 × 10−5 0.023 0.37 0.58 0.49 181 (1) 180 (2) 176 (4) 4.3 × 10−7 0.25 
14 rs8007115 94,407,241 2.2 × 10−5 0.017 0.38 0.78 0.49 181 (1) 180 (2) 176 (4) 5.4 × 10−7 0.37 
15 rs493218 51,277,554 0.77 5.2 × 10−7 0.32 0.10 0.074 149 (1) 145 (2) 142 (7) 8.9 × 10−3 2.4 × 10−4 
15 rs572221 51,291,924 0.83 6.6 × 10−7 0.26 0.088 0.056 149 (1) 145 (2) 142 (7) 8.3 × 10−3 3.6 × 10−4 
15 rs690271 51,291,964 0.83 5.0 × 10−7 0.26 0.085 0.050 149 (1) 145 (2) 142 (7) 7.6 × 10−3 3.4 × 10−4 
15 rs566369 51,295,884 0.82 5.0 × 10−7 0.26 0.085 0.050 149 (1) 145 (2) 142 (7) 7.6 × 10−3 3.4 × 10−4 
15 rs482541 51,296,486 0.82 5.0 × 10−7 0.26 0.085 0.050 149 (1) 145 (2) 142 (7) 7.6 × 10−3 3.4 × 10−4 

*Data are presented only for SNPs that were close to or met genome-wide significance (P < 5 × 10−8) from stage 2 using the longitudinal repeated measures in the conventional treatment group and either nominal significance in stage 3 for the intensive group, or reach genome-wide significance when both treatment groups were combined. For the intensive group only analysis, monthly measures were used. For the CON + INT analysis, only quarterly measures were used for the intensive group, so that they would be comparable to the conventional group. C homo, Het, and R homo are least square means of daily mean of the back-transformed Ln(glucose) in the common homozygote, heterozygote, and rare homozygote genotype groups, respectively, in one of the following groups: *CON,

†INT,

‡COMB. NB. The statistical analysis of the glucose measures was performed using normal scores.

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