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TABLE 5

Association of rs1358030 (SORCS1) with complications in the DCCT/EDIC

OutcomeConventional
Intensive
OR or HR (95% CI)POR or HR (95% CI)P
Hypoglycemia     
    Requiring medical assistance 0.63 (0.50–0.80) 0.0001 0.89 (0.72–1.10) 0.28 
    Resulting in coma/seizure 0.60 (0.44–0.81) 0.001 1.05 (0.84–1.31) 0.64 
Retinopathy     
    Mild nonproliferative retinopathy 1.15 (0.99–1.34) 0.07 1.16 (0.99–1.35) 0.07 
    Severe nonproliferative retinopathy 1.30 (1.04–1.63) 0.02 1.27 (0.92–1.77) 0.15 
    Clinically significant macular edema 1.16 (0.92–1.46) 0.22 1.10 (0.8–1.5) 0.57 
Nephropathy     
    Persistent microalbuminuria 1.25 (1.01–1.56) 0.04 1.25 (0.93–1.67) 0.14 
    Severe nephropathy 1.39 (1.04–1.87) 0.03 1.00 (0.61–1.64) 0.99 
Coronary calcium (β ± SE) 0.83 ± 0.36 0.05 0.68 ± 0.35 0.02 
Confirmed clinical neuropathy 1.32 (1.01–1.73) 0.05 1.08 (0.81–1.43) 0.19 
OutcomeConventional
Intensive
OR or HR (95% CI)POR or HR (95% CI)P
Hypoglycemia     
    Requiring medical assistance 0.63 (0.50–0.80) 0.0001 0.89 (0.72–1.10) 0.28 
    Resulting in coma/seizure 0.60 (0.44–0.81) 0.001 1.05 (0.84–1.31) 0.64 
Retinopathy     
    Mild nonproliferative retinopathy 1.15 (0.99–1.34) 0.07 1.16 (0.99–1.35) 0.07 
    Severe nonproliferative retinopathy 1.30 (1.04–1.63) 0.02 1.27 (0.92–1.77) 0.15 
    Clinically significant macular edema 1.16 (0.92–1.46) 0.22 1.10 (0.8–1.5) 0.57 
Nephropathy     
    Persistent microalbuminuria 1.25 (1.01–1.56) 0.04 1.25 (0.93–1.67) 0.14 
    Severe nephropathy 1.39 (1.04–1.87) 0.03 1.00 (0.61–1.64) 0.99 
Coronary calcium (β ± SE) 0.83 ± 0.36 0.05 0.68 ± 0.35 0.02 
Confirmed clinical neuropathy 1.32 (1.01–1.73) 0.05 1.08 (0.81–1.43) 0.19 

See supplementary Table 2 for definition of complications outcomes. Analysis was performed using additive coding of genotype, with the direction expressed as the number of copies of the C alleles (compared with the T allele). HR, hazard ratio; OR, odds ratio.

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