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TABLE 6

Association of rs10810632 (BNC2) with complications in the DCCT/EDIC

OutcomeConventional
Intensive
OR or HR (95% CI)POR or HR (95% CI)P
Hypoglycemia     
    Requiring medical assistance 0.49 (0.30–0.80) 0.004 1.02 (0.70–1.47) 0.94 
    Resulting in coma/seizure 0.60 (0.32–1.10) 0.10 0.89 (0.60–1.33) 0.58 
Retinopathy     
    Mild nonproliferative retinopathy 1.73 (1.31–2.27) 0.0002 1.02 (0.77–1.35) 0.90 
    Severe nonproliferative retinopathy 1.83 (1.29–2.62) 0.002 0.61 (0.3–1.25) 0.15 
    Clinically significant macular edema 1.87 (1.31–2.67) 0.001 0.97 (0.56–1.69) 0.92 
Nephropathy     
    Persistent microalbuminuria 1.84 (1.31–2.59) 0.001 0.80 (0.46–1.41) 0.43 
    Severe nephropathy 1.85 (1.19–2.87) 0.01 0.32 (0.08–1.31) 0.06 
Coronary calcium (β ± SE) 0.64 ± 0.62 0.30 1.34 ± 0.57 0.02 
Confirmed clinical neuropathy 1.64 (1.00–2.68) 0.05 0.69 (0.40–1.20) 0.6 
OutcomeConventional
Intensive
OR or HR (95% CI)POR or HR (95% CI)P
Hypoglycemia     
    Requiring medical assistance 0.49 (0.30–0.80) 0.004 1.02 (0.70–1.47) 0.94 
    Resulting in coma/seizure 0.60 (0.32–1.10) 0.10 0.89 (0.60–1.33) 0.58 
Retinopathy     
    Mild nonproliferative retinopathy 1.73 (1.31–2.27) 0.0002 1.02 (0.77–1.35) 0.90 
    Severe nonproliferative retinopathy 1.83 (1.29–2.62) 0.002 0.61 (0.3–1.25) 0.15 
    Clinically significant macular edema 1.87 (1.31–2.67) 0.001 0.97 (0.56–1.69) 0.92 
Nephropathy     
    Persistent microalbuminuria 1.84 (1.31–2.59) 0.001 0.80 (0.46–1.41) 0.43 
    Severe nephropathy 1.85 (1.19–2.87) 0.01 0.32 (0.08–1.31) 0.06 
Coronary calcium (β ± SE) 0.64 ± 0.62 0.30 1.34 ± 0.57 0.02 
Confirmed clinical neuropathy 1.64 (1.00–2.68) 0.05 0.69 (0.40–1.20) 0.6 

See legend to Table 5. Additive coding of genotype, with the direction expressed as the number of copies of the C alleles (compared with the T allele).

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