American Diabetes Association

TABLE 7

Association results of top 13 SNPs from DCCT with A1C in the MAGIC study of nondiabetic individuals

Chromosome	Position	SNP	Allele 1	Allele 2	Effect	SE	P	Sample size
BNC2 gene region
9	16,779,024	rs10810632	t	c	−0.0220	0.0065	7.1 × 10⁻⁴	36,446
9	16,779,436	rs6475082	a	g	−0.0235	0.0064	2.7 × 10⁻⁴	36,557
9	16,779,878	rs4961760	t	c	−0.0194	0.0065	0.0030	35,837
9	16,791,850	rs2254193	a	c	−0.0235	0.0066	3.5 × 10⁻⁴	36,458
SORCS1 gene region
10	108,113,589	rs1358030	a	g	0.0014	0.0036	0.70	35,304
GSC gene region
14	94,375,765	rs11624318	a	c	0.0016	0.0042	0.71	35,801
14	94,405,244	rs11160219	a	g	−0.0018	0.0044	0.68	32,898
14	94,407,241	rs8007115	t	c	−0.0012	0.0045	0.79	27,589
WDR72 gene region
15	51,277,554	rs493218	t	c	−0.0015	0.0057	0.79	36,530
15	51,291,924	rs572221	a	g	0.0015	0.0057	0.79	36,561
15	51,291,964	rs690271	a	g	0.0014	0.0057	0.81	36,585
15	51,295,884	rs566369	a	g	0.0012	0.0057	0.83	36,575
15	51,296,486	rs482541	a	g	0.0010	0.0057	0.86	36,577
18	22,727,740	rs163061	c	g	−0.0048	0.0041	0.25	33,297

Chromosome	Position	SNP	Allele 1	Allele 2	Effect	SE	P	Sample size
BNC2 gene region
9	16,779,024	rs10810632	t	c	−0.0220	0.0065	7.1 × 10⁻⁴	36,446
9	16,779,436	rs6475082	a	g	−0.0235	0.0064	2.7 × 10⁻⁴	36,557
9	16,779,878	rs4961760	t	c	−0.0194	0.0065	0.0030	35,837
9	16,791,850	rs2254193	a	c	−0.0235	0.0066	3.5 × 10⁻⁴	36,458
SORCS1 gene region
10	108,113,589	rs1358030	a	g	0.0014	0.0036	0.70	35,304
GSC gene region
14	94,375,765	rs11624318	a	c	0.0016	0.0042	0.71	35,801
14	94,405,244	rs11160219	a	g	−0.0018	0.0044	0.68	32,898
14	94,407,241	rs8007115	t	c	−0.0012	0.0045	0.79	27,589
WDR72 gene region
15	51,277,554	rs493218	t	c	−0.0015	0.0057	0.79	36,530
15	51,291,924	rs572221	a	g	0.0015	0.0057	0.79	36,561
15	51,291,964	rs690271	a	g	0.0014	0.0057	0.81	36,585
15	51,295,884	rs566369	a	g	0.0012	0.0057	0.83	36,575
15	51,296,486	rs482541	a	g	0.0010	0.0057	0.86	36,577
18	22,727,740	rs163061	c	g	−0.0048	0.0041	0.25	33,297

Allele 1 indicates the effect allele compared with allele 2 as the reference. Alleles are aligned to HapMap forward strand, but are not aligned in terms of minor or major allele. The A1C values were untransformed % [National Glycohemoglobin Standardization Program transformation: %A1C = 91.48 × (A1C/Hb) + 2.152], adjusted for age and sex.

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