American Diabetes Association

TABLE 1

Metabolic data in normoglycemic control and diabetic FXR KO mice

	WT	FXR KO	WT + STZ	FXR KO + STZ
Body weight (g)	44.2 ± 2.28	41.0 ± 1.98	28.4 ± 0.95^a	25.0 ± 1.27
Kidney weight (g)	0.36 ± 0.02	0.34 ± 0.01	0.38 ± 0.01	0.37 ± 0.01
Kidney/body weight ratio (%)	0.82 ± 0.02	0.84 ± 0.02	1.33 ± 0.06^a	1.48 ± 0.09
Plasma glucose (mg/dl)	193 ± 15	183 ± 12	769 ± 81	731 ± 85
Plasma TG (mg/dl)	12.7 ± 3.42	32.9 ± 6.20^a	54.4 ± 8.73^a	1,081 ± 603^bc
Plasma TC (mg/dl)	308 ± 25	487 ± 28^a	334 ± 38	1,217 ± 99^bc
Plasma HDL-C (mg/dl)	123 ± 9	181 ± 15^a	83.8 ± 2.4^a	26.3 ± 2.6^bc
Plasma LDL-C (mg/dl)	124 ± 14	202 ± 18^a	132 ± 17	905 ± 86^bc
Plasma insulin (ng/ml)	2.75 ± 0.37	2.25 ± 0.06	0.49 ± 0.06^a	0.64 ± 0.12^c
Urine ACR (mg/g)	25.4 ± 3.8	59.4 ± 11.2^a	30.7 ± 5.4	328 ± 66^bc
Glomerular volume (μm²)	3,286 ± 168	4,243 ± 179^a	4,129 ± 154^a	5,457 ± 263^bc

	WT	FXR KO	WT + STZ	FXR KO + STZ
Body weight (g)	44.2 ± 2.28	41.0 ± 1.98	28.4 ± 0.95^a	25.0 ± 1.27
Kidney weight (g)	0.36 ± 0.02	0.34 ± 0.01	0.38 ± 0.01	0.37 ± 0.01
Kidney/body weight ratio (%)	0.82 ± 0.02	0.84 ± 0.02	1.33 ± 0.06^a	1.48 ± 0.09
Plasma glucose (mg/dl)	193 ± 15	183 ± 12	769 ± 81	731 ± 85
Plasma TG (mg/dl)	12.7 ± 3.42	32.9 ± 6.20^a	54.4 ± 8.73^a	1,081 ± 603^bc
Plasma TC (mg/dl)	308 ± 25	487 ± 28^a	334 ± 38	1,217 ± 99^bc
Plasma HDL-C (mg/dl)	123 ± 9	181 ± 15^a	83.8 ± 2.4^a	26.3 ± 2.6^bc
Plasma LDL-C (mg/dl)	124 ± 14	202 ± 18^a	132 ± 17	905 ± 86^bc
Plasma insulin (ng/ml)	2.75 ± 0.37	2.25 ± 0.06	0.49 ± 0.06^a	0.64 ± 0.12^c
Urine ACR (mg/g)	25.4 ± 3.8	59.4 ± 11.2^a	30.7 ± 5.4	328 ± 66^bc
Glomerular volume (μm²)	3,286 ± 168	4,243 ± 179^a	4,129 ± 154^a	5,457 ± 263^bc

Data are means ± SE (n = 6 mice in each group):

^aP < 0.05 vs. WT + WD,

^bP < 0.05 vs. WT + STZ/WD,

^cP < 0.05 vs. FXR KO/WD. ACR, albumin/creatinine ratio; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; TC, total cholesterol; TG, triglyceride; WT, wild-type.

View Large

This Feature Is Available To Subscribers Only