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TABLE 1

Metabolic data in normoglycemic control and diabetic FXR KO mice

WTFXR KOWT + STZFXR KO + STZ
Body weight (g) 44.2 ± 2.28 41.0 ± 1.98 28.4 ± 0.95a 25.0 ± 1.27 
Kidney weight (g) 0.36 ± 0.02 0.34 ± 0.01 0.38 ± 0.01 0.37 ± 0.01 
Kidney/body weight ratio (%) 0.82 ± 0.02 0.84 ± 0.02 1.33 ± 0.06a 1.48 ± 0.09 
Plasma glucose (mg/dl) 193 ± 15 183 ± 12 769 ± 81 731 ± 85 
Plasma TG (mg/dl) 12.7 ± 3.42 32.9 ± 6.20a 54.4 ± 8.73a 1,081 ± 603bc 
Plasma TC (mg/dl) 308 ± 25 487 ± 28a 334 ± 38 1,217 ± 99bc 
Plasma HDL-C (mg/dl) 123 ± 9 181 ± 15a 83.8 ± 2.4a 26.3 ± 2.6bc 
Plasma LDL-C (mg/dl) 124 ± 14 202 ± 18a 132 ± 17 905 ± 86bc 
Plasma insulin (ng/ml) 2.75 ± 0.37 2.25 ± 0.06 0.49 ± 0.06a 0.64 ± 0.12c 
Urine ACR (mg/g) 25.4 ± 3.8 59.4 ± 11.2a 30.7 ± 5.4 328 ± 66bc 
Glomerular volume (μm23,286 ± 168 4,243 ± 179a 4,129 ± 154a 5,457 ± 263bc 
WTFXR KOWT + STZFXR KO + STZ
Body weight (g) 44.2 ± 2.28 41.0 ± 1.98 28.4 ± 0.95a 25.0 ± 1.27 
Kidney weight (g) 0.36 ± 0.02 0.34 ± 0.01 0.38 ± 0.01 0.37 ± 0.01 
Kidney/body weight ratio (%) 0.82 ± 0.02 0.84 ± 0.02 1.33 ± 0.06a 1.48 ± 0.09 
Plasma glucose (mg/dl) 193 ± 15 183 ± 12 769 ± 81 731 ± 85 
Plasma TG (mg/dl) 12.7 ± 3.42 32.9 ± 6.20a 54.4 ± 8.73a 1,081 ± 603bc 
Plasma TC (mg/dl) 308 ± 25 487 ± 28a 334 ± 38 1,217 ± 99bc 
Plasma HDL-C (mg/dl) 123 ± 9 181 ± 15a 83.8 ± 2.4a 26.3 ± 2.6bc 
Plasma LDL-C (mg/dl) 124 ± 14 202 ± 18a 132 ± 17 905 ± 86bc 
Plasma insulin (ng/ml) 2.75 ± 0.37 2.25 ± 0.06 0.49 ± 0.06a 0.64 ± 0.12c 
Urine ACR (mg/g) 25.4 ± 3.8 59.4 ± 11.2a 30.7 ± 5.4 328 ± 66bc 
Glomerular volume (μm23,286 ± 168 4,243 ± 179a 4,129 ± 154a 5,457 ± 263bc 

Data are means ± SE (n = 6 mice in each group):

aP < 0.05 vs. WT + WD,

bP < 0.05 vs. WT + STZ/WD,

cP < 0.05 vs. FXR KO/WD. ACR, albumin/creatinine ratio; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; TC, total cholesterol; TG, triglyceride; WT, wild-type.

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