Metabolic data in INT-747–treated diabetic mice
| . | WD . | STZ/WD . | INT-747/STZ/WD . |
|---|---|---|---|
| Body weight (g) | 39.2 ± 1.40 | 17.6 ± 0.35a | 17.8 ± 1.27 |
| Kidney weight (g) | 0.46 ± 0.02 | 0.47 ± 0.02 | 0.48 ± 0.02 |
| Kidney/body weight ratio (%) | 1.16 ± 0.04 | 2.70 ± 0.11a | 2.72 ± 0.0 |
| Plasma glucose (mg/dl) | 179 ± 6 | 651 ± 26a | 637 ± 47 |
| Plasma TG (mg/dl) | 195 ± 46 | 955 ± 163a | 906 ± 142 |
| Plasma TC (mg/dl) | 297 ± 17 | 1,452 ± 137a | 782 ± 112b |
| Plasma HDL-C (mg/dl) | 93.6 ± 6.4 | 115 ± 26 | 98.7 ± 8.7 |
| Plasma LDL-C (mg/dl) | 24.0 ± 3.9 | 727 ± 96a | 364 ± 87b |
| Plasma insulin (ng/ml) | 8.73 ± 2.53 | 0.26 ± 0.04a | 0.20 ± 0.01 |
| Urine ACR (mg/g) | 88.0 ± 10.7 | 603 ± 113a | 106 ± 23b |
| . | WD . | STZ/WD . | INT-747/STZ/WD . |
|---|---|---|---|
| Body weight (g) | 39.2 ± 1.40 | 17.6 ± 0.35a | 17.8 ± 1.27 |
| Kidney weight (g) | 0.46 ± 0.02 | 0.47 ± 0.02 | 0.48 ± 0.02 |
| Kidney/body weight ratio (%) | 1.16 ± 0.04 | 2.70 ± 0.11a | 2.72 ± 0.0 |
| Plasma glucose (mg/dl) | 179 ± 6 | 651 ± 26a | 637 ± 47 |
| Plasma TG (mg/dl) | 195 ± 46 | 955 ± 163a | 906 ± 142 |
| Plasma TC (mg/dl) | 297 ± 17 | 1,452 ± 137a | 782 ± 112b |
| Plasma HDL-C (mg/dl) | 93.6 ± 6.4 | 115 ± 26 | 98.7 ± 8.7 |
| Plasma LDL-C (mg/dl) | 24.0 ± 3.9 | 727 ± 96a | 364 ± 87b |
| Plasma insulin (ng/ml) | 8.73 ± 2.53 | 0.26 ± 0.04a | 0.20 ± 0.01 |
| Urine ACR (mg/g) | 88.0 ± 10.7 | 603 ± 113a | 106 ± 23b |
Data are means ± SE (n = 6 mice in each group):
aP < 0.05 vs. WT + WD,
bP < 0.05 vs. WT + STZ/WD. ACR, albumin/creatinine ratio; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; TC, total cholesterol; TG, triglyceride.