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TABLE 2

Metabolic data in INT-747–treated diabetic mice

WDSTZ/WDINT-747/STZ/WD
Body weight (g) 39.2 ± 1.40 17.6 ± 0.35a 17.8 ± 1.27 
Kidney weight (g) 0.46 ± 0.02 0.47 ± 0.02 0.48 ± 0.02 
Kidney/body weight ratio (%) 1.16 ± 0.04 2.70 ± 0.11a 2.72 ± 0.0 
Plasma glucose (mg/dl) 179 ± 6 651 ± 26a 637 ± 47 
Plasma TG (mg/dl) 195 ± 46 955 ± 163a 906 ± 142 
Plasma TC (mg/dl) 297 ± 17 1,452 ± 137a 782 ± 112b 
Plasma HDL-C (mg/dl) 93.6 ± 6.4 115 ± 26 98.7 ± 8.7 
Plasma LDL-C (mg/dl) 24.0 ± 3.9 727 ± 96a 364 ± 87b 
Plasma insulin (ng/ml) 8.73 ± 2.53 0.26 ± 0.04a 0.20 ± 0.01 
Urine ACR (mg/g) 88.0 ± 10.7 603 ± 113a 106 ± 23b 
WDSTZ/WDINT-747/STZ/WD
Body weight (g) 39.2 ± 1.40 17.6 ± 0.35a 17.8 ± 1.27 
Kidney weight (g) 0.46 ± 0.02 0.47 ± 0.02 0.48 ± 0.02 
Kidney/body weight ratio (%) 1.16 ± 0.04 2.70 ± 0.11a 2.72 ± 0.0 
Plasma glucose (mg/dl) 179 ± 6 651 ± 26a 637 ± 47 
Plasma TG (mg/dl) 195 ± 46 955 ± 163a 906 ± 142 
Plasma TC (mg/dl) 297 ± 17 1,452 ± 137a 782 ± 112b 
Plasma HDL-C (mg/dl) 93.6 ± 6.4 115 ± 26 98.7 ± 8.7 
Plasma LDL-C (mg/dl) 24.0 ± 3.9 727 ± 96a 364 ± 87b 
Plasma insulin (ng/ml) 8.73 ± 2.53 0.26 ± 0.04a 0.20 ± 0.01 
Urine ACR (mg/g) 88.0 ± 10.7 603 ± 113a 106 ± 23b 

Data are means ± SE (n = 6 mice in each group):

aP < 0.05 vs. WT + WD,

bP < 0.05 vs. WT + STZ/WD. ACR, albumin/creatinine ratio; HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; TC, total cholesterol; TG, triglyceride.

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