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TABLE 1

Haplotype association of MAFA with susceptibility to high-risk type 1 diabetes

HaplotypePolymorphism
Frequency
OR (95% CI)P value
+69 VNTR+1,377 G/THigh-risk case subjects*Control subjects
MAFA-ht1 1R G (Gly) 0.721 0.700 1.11 (0.78–1.53) NS 
MAFA-ht2 Non-1R G (Gly) 0.266 0.249 1.10 (0.77–1.57) NS 
MAFA-ht3 1R T (Cys) 0.012 0.051 0.23 (0.07–0.70) 0.0089 
HaplotypePolymorphism
Frequency
OR (95% CI)P value
+69 VNTR+1,377 G/THigh-risk case subjects*Control subjects
MAFA-ht1 1R G (Gly) 0.721 0.700 1.11 (0.78–1.53) NS 
MAFA-ht2 Non-1R G (Gly) 0.266 0.249 1.10 (0.77–1.57) NS 
MAFA-ht3 1R T (Cys) 0.012 0.051 0.23 (0.07–0.70) 0.0089 

*High-risk case subjects: type 1 diabetic patients with the high-risk IDDM2 allele (−23Hph+/+). Fisher direct probability test. NS, not significant.

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