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TABLE 2

Adjusted hazard ratios (HRs; 95% CI) for incident heart failure (HF) according to A1C categories

Models*Categories of A1C, range (%)
trend P
<5.05.0–5.45.5–5.96.0–6.4
Model 1      
    No. of cases/subjects 50/1,012 307/5,263 361/3,883 123/899  
    HR (95% CI) 0.92 (0.68–1.24) Reference 1.44 (1.24–1.68) 2.04 (1.63–2.54) <0.001 
Model 2      
    No. of cases/subjects 45/970 289/5,078 338/3,707 111/840  
    HR (95% CI) 0.96 (0.70–1.31) Reference 1.16 (0.98–1.36) 1.38 (1.09–1.75) 0.006 
Model 3      
    No. of cases/subjects 45/955 285/5,002 329/3,642 110/824  
    HR (95% CI) 0.96 (0.70–1.32) Reference 1.16 (0.98–1.37) 1.40 (1.09–1.79) 0.008 
Models*Categories of A1C, range (%)
trend P
<5.05.0–5.45.5–5.96.0–6.4
Model 1      
    No. of cases/subjects 50/1,012 307/5,263 361/3,883 123/899  
    HR (95% CI) 0.92 (0.68–1.24) Reference 1.44 (1.24–1.68) 2.04 (1.63–2.54) <0.001 
Model 2      
    No. of cases/subjects 45/970 289/5,078 338/3,707 111/840  
    HR (95% CI) 0.96 (0.70–1.31) Reference 1.16 (0.98–1.36) 1.38 (1.09–1.75) 0.006 
Model 3      
    No. of cases/subjects 45/955 285/5,002 329/3,642 110/824  
    HR (95% CI) 0.96 (0.70–1.32) Reference 1.16 (0.98–1.37) 1.40 (1.09–1.79) 0.008 

*Model 1: adjusted for age, race, and sex. Model 2: model 1 + level of education, carotid atherosclerosis, systolic blood pressure, antihypertensive medication, smoking, alcohol intake, BMI, LDL-C, HDL-C, a history of CHD at baseline, and eGFR. Model 3: model 2 + fasting glucose.

†Participants with all variables used in model 2.

‡Participants with all variables used in model 2 and fasting glucose.

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