Adjusted hazard ratios (HRs; 95% CI) for incident heart failure (HF) according to A1C categories
| Models* . | Categories of A1C, range (%) . | trend P . | |||
|---|---|---|---|---|---|
| <5.0 . | 5.0–5.4 . | 5.5–5.9 . | 6.0–6.4 . | ||
| Model 1 | |||||
| No. of cases/subjects | 50/1,012 | 307/5,263 | 361/3,883 | 123/899 | |
| HR (95% CI) | 0.92 (0.68–1.24) | Reference | 1.44 (1.24–1.68) | 2.04 (1.63–2.54) | <0.001 |
| Model 2 | |||||
| No. of cases/subjects† | 45/970 | 289/5,078 | 338/3,707 | 111/840 | |
| HR (95% CI) | 0.96 (0.70–1.31) | Reference | 1.16 (0.98–1.36) | 1.38 (1.09–1.75) | 0.006 |
| Model 3 | |||||
| No. of cases/subjects‡ | 45/955 | 285/5,002 | 329/3,642 | 110/824 | |
| HR (95% CI) | 0.96 (0.70–1.32) | Reference | 1.16 (0.98–1.37) | 1.40 (1.09–1.79) | 0.008 |
| Models* . | Categories of A1C, range (%) . | trend P . | |||
|---|---|---|---|---|---|
| <5.0 . | 5.0–5.4 . | 5.5–5.9 . | 6.0–6.4 . | ||
| Model 1 | |||||
| No. of cases/subjects | 50/1,012 | 307/5,263 | 361/3,883 | 123/899 | |
| HR (95% CI) | 0.92 (0.68–1.24) | Reference | 1.44 (1.24–1.68) | 2.04 (1.63–2.54) | <0.001 |
| Model 2 | |||||
| No. of cases/subjects† | 45/970 | 289/5,078 | 338/3,707 | 111/840 | |
| HR (95% CI) | 0.96 (0.70–1.31) | Reference | 1.16 (0.98–1.36) | 1.38 (1.09–1.75) | 0.006 |
| Model 3 | |||||
| No. of cases/subjects‡ | 45/955 | 285/5,002 | 329/3,642 | 110/824 | |
| HR (95% CI) | 0.96 (0.70–1.32) | Reference | 1.16 (0.98–1.37) | 1.40 (1.09–1.79) | 0.008 |
*Model 1: adjusted for age, race, and sex. Model 2: model 1 + level of education, carotid atherosclerosis, systolic blood pressure, antihypertensive medication, smoking, alcohol intake, BMI, LDL-C, HDL-C, a history of CHD at baseline, and eGFR. Model 3: model 2 + fasting glucose.
†Participants with all variables used in model 2.
‡Participants with all variables used in model 2 and fasting glucose.