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TABLE 4

Adjusted* HRs (95% CI) for incident HF according to the combination of A1C and fasting glucose categories

Categories of fasting glucose, mmol/lCategories of A1C, %
<5.05.0–5.45.5–5.96.0–6.4
<5.0     
    No. of cases/subjects 10/151 29/576 22/212 5/26 
    HR (95% CI) 1.99 (1.04–3.81) 1.42 (0.94–2.15) 1.75 (1.10–2.79) 3.57 (1.45–8.79) 
5.0–5.5     
    No. of cases/subjects 15/444 104/2,151 83/1,075 25/131 
    HR (95% CI) 0.83 (0.49–1.44) Reference 1.18 (0.88–1.58) 2.19 (1.40–3.43) 
5.6–6.0     
    No. of cases/subjects 17/288 108/1,736 126/1,499 32/312 
    HR (95% CI) 1.15 (0.68–1.92) 1.11 (0.85–1.45) 1.16 (0.89–1.51) 1.29 (0.86–1.94) 
6.1–6.9     
    No. of cases/subjects 3/87 48/615 107/921 49/371 
    HR (95% CI) 0.62 (0.20–1.96) 1.20 (0.85–1.70) 1.44 (1.09–1.90) 1.38 (0.97–1.96) 
Categories of fasting glucose, mmol/lCategories of A1C, %
<5.05.0–5.45.5–5.96.0–6.4
<5.0     
    No. of cases/subjects 10/151 29/576 22/212 5/26 
    HR (95% CI) 1.99 (1.04–3.81) 1.42 (0.94–2.15) 1.75 (1.10–2.79) 3.57 (1.45–8.79) 
5.0–5.5     
    No. of cases/subjects 15/444 104/2,151 83/1,075 25/131 
    HR (95% CI) 0.83 (0.49–1.44) Reference 1.18 (0.88–1.58) 2.19 (1.40–3.43) 
5.6–6.0     
    No. of cases/subjects 17/288 108/1,736 126/1,499 32/312 
    HR (95% CI) 1.15 (0.68–1.92) 1.11 (0.85–1.45) 1.16 (0.89–1.51) 1.29 (0.86–1.94) 
6.1–6.9     
    No. of cases/subjects 3/87 48/615 107/921 49/371 
    HR (95% CI) 0.62 (0.20–1.96) 1.20 (0.85–1.70) 1.44 (1.09–1.90) 1.38 (0.97–1.96) 

*Adjusted for age, race, and sex, level of education, carotid atherosclerosis, systolic blood pressure, antihypertensive medication, smoking, alcohol intake, BMI, LDL-C, HDL-C, a history of CHD at baseline, and eGFR.

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