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TABLE 1

Clinical characteristics of male study participants according to the TCF7L2 rs7903146 genotype before and after bed rest

rs7903146Before bed rest
After bed rest
TT/CTCCTT/CTCC
n 21 17 21 17 
Age (years) 25.6 ± 2.0 25.2 ± 2 25.6 ± 2.0 25.2 ± 2.1 
Weight (kg) 75.6 ± 11.7 82.4 ± 11.8 76.8 ± 10.4 81.5 ± 12.2 
Height (m) 1.81 ± 0.06 1.82 ± 0.06 1.81 ± 0.06 1.82 ± 0.06 
BMI (kg/m223.0 ± 2.7 24.4 ± 3.1 23.2 ± 2.5 24.5 ± 3.0 
Vo2 max (ml · min−1 · kg−143.0 ± 6.8 43.7 ± 7.8 42.9 ± 7.1 40.7 ± 7.8* 
Systolic blood pressure (mmHg) 125 ± 10 129 ± 14 124 ± 11 127 ± 10 
Diastolic blood pressure (mmHg) 69 ± 8 70 ± 10 70 ± 5 70 ± 8 
Waist-to-hip ratio 0.85 ± 0.05 0.86 ± 0.05 0.85 ± 0.06 0.87 ± 0.06 
Total fat mass (kg) 12.6 ± 6.6 16.7 ± 8.3 12.9 ± 6.9 17.2 ± 8.8 
Whole-body fat percentage (%) 16.5 ± 6.5 19.8 ± 7.5 16.2 ± 6.6 20.3 ± 7.8 
Trunk fat mass-to-total fat mass ratio 0.50 ± 0.04 0.51 ± 0.04 0.50 ± 0.05 0.52 ± 0.05 
Leg fat mass-to-total fat mass ratio† 0.36 ± 0.04 0.35 ± 0.03 0.35 ± 0.04 0.35 ± 0.04 
Percent trunk fat mass-to-leg fat mass ratio 1.41 ± 0.29 1.48 ± 0.30 1.46 ± 0.35 1.53 ± 0.33 
Triglycerides (mmol/l) 0.9 ± 0.3 1.1 ± 0.9 0.9 ± 0.3 1.2 ± 0.6 
Cholesterol (mmol/l) 3.8 ± 0.6 4.2 ± 1.0 3.8 ± 1.0 3.8 ± 1.0* 
HDL (mmol/l) 1.2 ± 0.2 1.3 ± 0.5 1.2 ± 0.2 1.1 ± 0.4* 
LDL (mmol/l) 2.1 ± 0.5 2.3 ± 1.0 2.2 ± 0.6 2.0 ± 0.6 
VLDL (mmol/l) 0.4 ± 0.2 0.5 ± 0.4 0.4 ± 0.2 0.5 ± 0.3 
rs7903146Before bed rest
After bed rest
TT/CTCCTT/CTCC
n 21 17 21 17 
Age (years) 25.6 ± 2.0 25.2 ± 2 25.6 ± 2.0 25.2 ± 2.1 
Weight (kg) 75.6 ± 11.7 82.4 ± 11.8 76.8 ± 10.4 81.5 ± 12.2 
Height (m) 1.81 ± 0.06 1.82 ± 0.06 1.81 ± 0.06 1.82 ± 0.06 
BMI (kg/m223.0 ± 2.7 24.4 ± 3.1 23.2 ± 2.5 24.5 ± 3.0 
Vo2 max (ml · min−1 · kg−143.0 ± 6.8 43.7 ± 7.8 42.9 ± 7.1 40.7 ± 7.8* 
Systolic blood pressure (mmHg) 125 ± 10 129 ± 14 124 ± 11 127 ± 10 
Diastolic blood pressure (mmHg) 69 ± 8 70 ± 10 70 ± 5 70 ± 8 
Waist-to-hip ratio 0.85 ± 0.05 0.86 ± 0.05 0.85 ± 0.06 0.87 ± 0.06 
Total fat mass (kg) 12.6 ± 6.6 16.7 ± 8.3 12.9 ± 6.9 17.2 ± 8.8 
Whole-body fat percentage (%) 16.5 ± 6.5 19.8 ± 7.5 16.2 ± 6.6 20.3 ± 7.8 
Trunk fat mass-to-total fat mass ratio 0.50 ± 0.04 0.51 ± 0.04 0.50 ± 0.05 0.52 ± 0.05 
Leg fat mass-to-total fat mass ratio† 0.36 ± 0.04 0.35 ± 0.03 0.35 ± 0.04 0.35 ± 0.04 
Percent trunk fat mass-to-leg fat mass ratio 1.41 ± 0.29 1.48 ± 0.30 1.46 ± 0.35 1.53 ± 0.33 
Triglycerides (mmol/l) 0.9 ± 0.3 1.1 ± 0.9 0.9 ± 0.3 1.2 ± 0.6 
Cholesterol (mmol/l) 3.8 ± 0.6 4.2 ± 1.0 3.8 ± 1.0 3.8 ± 1.0* 
HDL (mmol/l) 1.2 ± 0.2 1.3 ± 0.5 1.2 ± 0.2 1.1 ± 0.4* 
LDL (mmol/l) 2.1 ± 0.5 2.3 ± 1.0 2.2 ± 0.6 2.0 ± 0.6 
VLDL (mmol/l) 0.4 ± 0.2 0.5 ± 0.4 0.4 ± 0.2 0.5 ± 0.3 

Data are means ± SD.

*Significant difference before versus after bed rest; P < 0.05. †Log-transformed data.

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