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TABLE 2

Data on IVGTT, hyperinsulinemic-euglycemic clamp, and indirect calorimetry in male study participants according to TCF7L2 rs7903146 genotype before and after bed rest

rs7903146Before bed rest
After bed rest
TT/CTCCTT/CTCC
n 21 17 21 17 
Plasma glucose (mmol/l)     
    Basal 4.6 ± 0.4 4.6 ± 0.5 4.6 ± 0.4 4.6 ± 0.4 
    Insulin-stimulated state 5.0 ± 0.2 5.0 ± 0.2 5.0 ± 0.4 5.1 ± 0.4 
Plasma insulin (pmol/l)*     
    Basal 26 ± 14 33 ± 23 30 ± 11 47 ± 27 
    Insulin-stimulated state 745 ± 151 848 ± 258 821 ± 186 837 ± 192 
Plasma glucagon (pmol/l)     
    Basal 6.7 ± 2.9 10.5 ± 4.3§ 6.7 ± 3.6 9.4 ± 4.0 
HOMA-IR+ (10−6 × mmol−1 · l−1 · mmol−1 · l−1)*     
    Basal 5.3 ± 3.2 6.9 ± 5.2 6.1 ± 2.5 9.7 ± 5.8 
M value (mg · min−1 · kg fat-free mass−1    
    Insulin-stimulated state 14.0 ± 1.9 14.0 ± 1.8 11.0 ± 1.7 10.0 ± 2.5 
Glucose oxidation rate (mg · min−1 · kg−1 fat-free mass)     
    Basal 1.6 ± 0.4 1.4 ± 0.4 2.3 ± 0.9 2.8 ± 0.7 
    Insulin-stimulated state 4.2 ± 0.6 4.3 ± 0.6 4.5 ± 0.6 4.2 ± 0.7 
Fat oxidation rate (mg · min−1 · kg−1 fat-free mass)     
    Basal 1.0 ± 0.3 1.1 ± 0.4 0.7 ± 0.4 0.5 ± 0.3 
    Insulin-stimulated state 0.1 ± 0.2 0.2 ± 0.4 −0.1 ± 0.3 0.1 ± 0.3 
Nonoxidative glucose oxidation rate (mg · min−1 · kg−1 fat-free mass)     
    Insulin-stimulated state 9.9 ± 1.7 9.7 ± 2.0 6.5 ± 1.5 6.4 ± 1.8 
FPIR (pmol−1 · l−1 · min−1)* 1,559 ± 1,330 2,122 ± 1,464§ 2,108 ± 1,339 3,503 ± 1,670 
Second-phase insulin response (pmol−1 · l−1 · min−1)* 2,671 ± 2,954 2,618 ± 602 2,632 ± 1,012 4,960 ± 2,778 
AUCtotal (pmol−1 · l−1 · min−1)* 4,469 ± 3,905 5,032 ± 2,985 5,026 ± 2,190 8,946 ± 4,063 
Di-peripheral (10−3 × pmol · ml−1 · min−1 · mg−1 · min−1 · kg fat-free mass−1)*     
    Insulin-stimulated state 21.9 ± 20.4 30.4 ± 21.5§ 24.0 ± 16.2 34.3 ± 17.7 
Di-hepatic (pmol · l−1 · min−1 · μmol−1 · min−1 · kg fat-free mass−1 · pmol−1 · l−1)*     
    Insulin-stimulated state 6.6 ± 6.4 14.2 ± 18.1 7.8 ± 5.6 9.4 ± 6.0 
rs7903146Before bed rest
After bed rest
TT/CTCCTT/CTCC
n 21 17 21 17 
Plasma glucose (mmol/l)     
    Basal 4.6 ± 0.4 4.6 ± 0.5 4.6 ± 0.4 4.6 ± 0.4 
    Insulin-stimulated state 5.0 ± 0.2 5.0 ± 0.2 5.0 ± 0.4 5.1 ± 0.4 
Plasma insulin (pmol/l)*     
    Basal 26 ± 14 33 ± 23 30 ± 11 47 ± 27 
    Insulin-stimulated state 745 ± 151 848 ± 258 821 ± 186 837 ± 192 
Plasma glucagon (pmol/l)     
    Basal 6.7 ± 2.9 10.5 ± 4.3§ 6.7 ± 3.6 9.4 ± 4.0 
HOMA-IR+ (10−6 × mmol−1 · l−1 · mmol−1 · l−1)*     
    Basal 5.3 ± 3.2 6.9 ± 5.2 6.1 ± 2.5 9.7 ± 5.8 
M value (mg · min−1 · kg fat-free mass−1    
    Insulin-stimulated state 14.0 ± 1.9 14.0 ± 1.8 11.0 ± 1.7 10.0 ± 2.5 
Glucose oxidation rate (mg · min−1 · kg−1 fat-free mass)     
    Basal 1.6 ± 0.4 1.4 ± 0.4 2.3 ± 0.9 2.8 ± 0.7 
    Insulin-stimulated state 4.2 ± 0.6 4.3 ± 0.6 4.5 ± 0.6 4.2 ± 0.7 
Fat oxidation rate (mg · min−1 · kg−1 fat-free mass)     
    Basal 1.0 ± 0.3 1.1 ± 0.4 0.7 ± 0.4 0.5 ± 0.3 
    Insulin-stimulated state 0.1 ± 0.2 0.2 ± 0.4 −0.1 ± 0.3 0.1 ± 0.3 
Nonoxidative glucose oxidation rate (mg · min−1 · kg−1 fat-free mass)     
    Insulin-stimulated state 9.9 ± 1.7 9.7 ± 2.0 6.5 ± 1.5 6.4 ± 1.8 
FPIR (pmol−1 · l−1 · min−1)* 1,559 ± 1,330 2,122 ± 1,464§ 2,108 ± 1,339 3,503 ± 1,670 
Second-phase insulin response (pmol−1 · l−1 · min−1)* 2,671 ± 2,954 2,618 ± 602 2,632 ± 1,012 4,960 ± 2,778 
AUCtotal (pmol−1 · l−1 · min−1)* 4,469 ± 3,905 5,032 ± 2,985 5,026 ± 2,190 8,946 ± 4,063 
Di-peripheral (10−3 × pmol · ml−1 · min−1 · mg−1 · min−1 · kg fat-free mass−1)*     
    Insulin-stimulated state 21.9 ± 20.4 30.4 ± 21.5§ 24.0 ± 16.2 34.3 ± 17.7 
Di-hepatic (pmol · l−1 · min−1 · μmol−1 · min−1 · kg fat-free mass−1 · pmol−1 · l−1)*     
    Insulin-stimulated state 6.6 ± 6.4 14.2 ± 18.1 7.8 ± 5.6 9.4 ± 6.0 

Data are means ± SD.

*Log-transformed data.

†Significant difference between the TT/CT and CC groups after bed rest, P < 0.05.

‡Significant difference before versus after bed rest; P < 0.05. Significant difference between the TT/CT and CC groups before bed rest,

§P < 0.05 and

P = 0.05.

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