The rate of hepatic insulin action and whole-body lipolysis in male study participants according to TCF7L2 rs7903146 genotype in response to bed rest
| rs7903146 . | Before bed rest . | After bed rest . | ||
|---|---|---|---|---|
| TT/CT . | CC . | TT/CT . | CC . | |
| n | 21 | 17 | 21 | 17 |
| Ra glucose (μmol · min−1 · kg fat-free mass−1) | 10.5 ± 2.3 | 8.9 ± 3.7 | 10.7 ± 3.3 | 11.2 ± 3.4 |
| HIR index* | 267 ± 156 | 282 ± 165 | 310 ± 123 | 540 ± 369†‡ |
| Ra glycerol (μmol · min−1 · kg fat-free mass−1)* | 3.9 ± 2.8 | 3.3 ± 2.0 | 2.7 ± 1.6 | 3.0 ± 2.0 |
| rs7903146 . | Before bed rest . | After bed rest . | ||
|---|---|---|---|---|
| TT/CT . | CC . | TT/CT . | CC . | |
| n | 21 | 17 | 21 | 17 |
| Ra glucose (μmol · min−1 · kg fat-free mass−1) | 10.5 ± 2.3 | 8.9 ± 3.7 | 10.7 ± 3.3 | 11.2 ± 3.4 |
| HIR index* | 267 ± 156 | 282 ± 165 | 310 ± 123 | 540 ± 369†‡ |
| Ra glycerol (μmol · min−1 · kg fat-free mass−1)* | 3.9 ± 2.8 | 3.3 ± 2.0 | 2.7 ± 1.6 | 3.0 ± 2.0 |
Data are means ± SD.
*Log-transformed data.
†Significant difference between TT/CT and CC group after bed rest, P < 0.05.
‡Significant difference before versus after bed rest; P < 0.05. Ra glucose, glucose rate of appearance; Ra glycerol, glycerol rate of appearance of glycerol.