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TABLE 3

The rate of hepatic insulin action and whole-body lipolysis in male study participants according to TCF7L2 rs7903146 genotype in response to bed rest

rs7903146Before bed rest
After bed rest
TT/CTCCTT/CTCC
n 21 17 21 17 
Ra glucose (μmol · min−1 · kg fat-free mass−110.5 ± 2.3 8.9 ± 3.7 10.7 ± 3.3 11.2 ± 3.4 
HIR index* 267 ± 156 282 ± 165 310 ± 123 540 ± 369 
Ra glycerol (μmol · min−1 · kg fat-free mass−1)* 3.9 ± 2.8 3.3 ± 2.0 2.7 ± 1.6 3.0 ± 2.0 
rs7903146Before bed rest
After bed rest
TT/CTCCTT/CTCC
n 21 17 21 17 
Ra glucose (μmol · min−1 · kg fat-free mass−110.5 ± 2.3 8.9 ± 3.7 10.7 ± 3.3 11.2 ± 3.4 
HIR index* 267 ± 156 282 ± 165 310 ± 123 540 ± 369 
Ra glycerol (μmol · min−1 · kg fat-free mass−1)* 3.9 ± 2.8 3.3 ± 2.0 2.7 ± 1.6 3.0 ± 2.0 

Data are means ± SD.

*Log-transformed data.

†Significant difference between TT/CT and CC group after bed rest, P < 0.05.

‡Significant difference before versus after bed rest; P < 0.05. Raglucose, glucose rate of appearance; Raglycerol, glycerol rate of appearance of glycerol.

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