Physiological and metabolic parameters in normal rats following AGE-RSA injections
| . | Plasma glucose (mmol/L) . | Glycated hemoglobin (%) . | Body weight (g) . | Plasma CML (μmol/mol lysine) . | Energy intake (kJ/day) . |
|---|---|---|---|---|---|
| AGE-RSA | 7.8 ± 0.5 | 4.7 ± 0.6* | 548 ± 37* | 359.2 ± 57.7 | 358.7 ± 40.1 |
| RSA | 7.4 ± 1.0 | 4.2 ± 0.8* | 529 ± 58 | 311.7 ± 38.42 | 351.1 ± 80.1 |
| AGE-RSA+ALT | 7.6 ± 0.5 | 4.5 ± 0.5* | 567 ± 50 | 217 ± 18.2*† | 351.1 ± 56.3 |
| Sham | 7.4 ± 0.5 | 3.0 ± 0.3 | 629 ± 67 | 304.6 ± 25.6 | 316.0 ± 58.1 |
| . | Plasma glucose (mmol/L) . | Glycated hemoglobin (%) . | Body weight (g) . | Plasma CML (μmol/mol lysine) . | Energy intake (kJ/day) . |
|---|---|---|---|---|---|
| AGE-RSA | 7.8 ± 0.5 | 4.7 ± 0.6* | 548 ± 37* | 359.2 ± 57.7 | 358.7 ± 40.1 |
| RSA | 7.4 ± 1.0 | 4.2 ± 0.8* | 529 ± 58 | 311.7 ± 38.42 | 351.1 ± 80.1 |
| AGE-RSA+ALT | 7.6 ± 0.5 | 4.5 ± 0.5* | 567 ± 50 | 217 ± 18.2*† | 351.1 ± 56.3 |
| Sham | 7.4 ± 0.5 | 3.0 ± 0.3 | 629 ± 67 | 304.6 ± 25.6 | 316.0 ± 58.1 |
Data are means ± SD. Plasma glucose and glycated hemoglobin are included as measures of glycemic control at 4 months; n = 10 rats/group. Final body weight, plasma CML (AGE) concentrations, and energy intake following metabolic caging are also shown.
*P < 0.05 vs. sham.
†P < 0.05 vs. AGE-RSA.