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TABLE 1

Physiological and metabolic parameters in normal rats following AGE-RSA injections

Plasma glucose (mmol/L)Glycated hemoglobin (%)Body weight (g)Plasma CML (μmol/mol lysine)Energy intake (kJ/day)
AGE-RSA 7.8 ± 0.5 4.7 ± 0.6* 548 ± 37* 359.2 ± 57.7 358.7 ± 40.1 
RSA 7.4 ± 1.0 4.2 ± 0.8* 529 ± 58 311.7 ± 38.42 351.1 ± 80.1 
AGE-RSA+ALT 7.6 ± 0.5 4.5 ± 0.5* 567 ± 50 217 ± 18.2* 351.1 ± 56.3 
Sham 7.4 ± 0.5 3.0 ± 0.3 629 ± 67 304.6 ± 25.6 316.0 ± 58.1 
Plasma glucose (mmol/L)Glycated hemoglobin (%)Body weight (g)Plasma CML (μmol/mol lysine)Energy intake (kJ/day)
AGE-RSA 7.8 ± 0.5 4.7 ± 0.6* 548 ± 37* 359.2 ± 57.7 358.7 ± 40.1 
RSA 7.4 ± 1.0 4.2 ± 0.8* 529 ± 58 311.7 ± 38.42 351.1 ± 80.1 
AGE-RSA+ALT 7.6 ± 0.5 4.5 ± 0.5* 567 ± 50 217 ± 18.2* 351.1 ± 56.3 
Sham 7.4 ± 0.5 3.0 ± 0.3 629 ± 67 304.6 ± 25.6 316.0 ± 58.1 

Data are means ± SD. Plasma glucose and glycated hemoglobin are included as measures of glycemic control at 4 months; n = 10 rats/group. Final body weight, plasma CML (AGE) concentrations, and energy intake following metabolic caging are also shown.

*P < 0.05 vs. sham.

P < 0.05 vs. AGE-RSA.

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