Total zinc intake and the genetic variants meta-analyzed interactions on fasting glucose levels*
| SNP . | Chromosome . | Nearest gene . | Effect/other allele . | Effect allele frequency . | n . | Cohorts . | Interaction (total zinc × SNPs) [β (SE)] . | Interaction P . | I2 (%) (95% CI) . | Q test P . |
|---|---|---|---|---|---|---|---|---|---|---|
| Glucose-related | ||||||||||
| rs340874 | 1 | PROX1 | C/T | 0.52 | 34,037 | 5 | −0.0012 (0.0005) | 0.03 | 0 (0–79) | 0.99 |
| rs780094 | 2 | GCKR | C/T | 0.58 | 34,307 | 5 | 0.0004 (0.0005) | 0.35 | 0 (0–79) | 0.97 |
| rs560887 | 2 | G6PC2 | C/T | 0.71 | 34,061 | 5 | 3 × 10−5 (0.0005) | 0.95 | 0 (0–79) | 0.84 |
| rs11708067 | 3 | ADCY5 | A/G | 0.76 | 34,111 | 5 | −0.0011 (0.0006) | 0.05 | 25 (0–70) | 0.25 |
| rs11920090 | 3 | SLC2A2 | T/A | 0.83 | 34,033 | 5 | 0.0003 (0.0007) | 0.70 | 42 (0–79) | 0.14 |
| rs2191349 | 7 | DGKB/TMEM195 | T/G | 0.54 | 34,108 | 5 | −0.0002 (0.0005) | 0.71 | 0 (0–79) | 0.47 |
| rs4607517 | 7 | GCK | A/G | 0.21 | 34,333 | 5 | −0.0003 (0.0006) | 0.58 | 34 (0–75) | 0.19 |
| rs11558471 | 8 | SLC30A8 | A/G | 0.70 | 34,150 | 5 | −0.0017 (0.0006) | 0.005 | 0 (0–79) | 0.78 |
| rs7034200 | 9 | GLIS3 | A/C | 0.49 | 33,874 | 5 | 2 × 10−5 (0.0005) | 0.97 | 0 (0–79) | 0.76 |
| rs10885122 | 10 | ADRA2A | G/T | 0.85 | 33,933 | 5 | 0.0002 (0.0008) | 0.75 | 25 (0–70) | 0.25 |
| rs4506565 | 10 | TCF7L2 | T/A | 0.32 | 18,235 | 4 | 0.0002 (0.0005) | 0.71 | 57 (0–86) | 0.07 |
| rs11605924 | 11 | CRY2 | A/C | 0.47 | 34,137 | 5 | 0.0007 (0.0005) | 0.16 | 30 (0–73) | 0.22 |
| rs7944584 | 11 | MADD | A/T | 0.69 | 33,921 | 5 | −0.0004 (0.0006) | 0.44 | 8 (0–81) | 0.36 |
| rs174550 | 11 | FADS1 | T/C | 0.66 | 34,172 | 5 | −0.0005 (0.0005) | 0.33 | 0 (0–79) | 0.82 |
| rs10830963 | 11 | MTNR1B | G/C | 0.28 | 34,009 | 5 | 0.0001 (0.0006) | 0.91 | 48 (0–81) | 0.11 |
| rs11071657 | 15 | C2CD4B | A/G | 0.61 | 33,962 | 5 | 0.0003 (0.0005) | 0.55 | 9 (0–81) | 0.36 |
| Insulin-related | ||||||||||
| rs4675095 | 2 | IRS1 | T/A | 0.06 | 18,241 | 4 | 0.0003 (0.0008) | 0.74 | 0 (0–85) | 0.76 |
| rs35767 | 12 | IGF1 | G/A | 0.81 | 33,888 | 4 | 0.0001 (0.0007) | 0.92 | 0 (0–79) | 0.82 |
| Zinc-related | ||||||||||
| rs10493846 | 1 | SEC63D1 | G/T | 0.74 | 18,158 | 4 | −0.0005 (0.0006) | 0.37 | 0 (0–79) | 0.61 |
| rs11167682 | 5 | SAP30 L | G/T | 0.76 | 18,249 | 5 | 0.0001 (0.0006) | 0.91 | 0 (0–85) | 0.91 |
| SNP . | Chromosome . | Nearest gene . | Effect/other allele . | Effect allele frequency . | n . | Cohorts . | Interaction (total zinc × SNPs) [β (SE)] . | Interaction P . | I2 (%) (95% CI) . | Q test P . |
|---|---|---|---|---|---|---|---|---|---|---|
| Glucose-related | ||||||||||
| rs340874 | 1 | PROX1 | C/T | 0.52 | 34,037 | 5 | −0.0012 (0.0005) | 0.03 | 0 (0–79) | 0.99 |
| rs780094 | 2 | GCKR | C/T | 0.58 | 34,307 | 5 | 0.0004 (0.0005) | 0.35 | 0 (0–79) | 0.97 |
| rs560887 | 2 | G6PC2 | C/T | 0.71 | 34,061 | 5 | 3 × 10−5 (0.0005) | 0.95 | 0 (0–79) | 0.84 |
| rs11708067 | 3 | ADCY5 | A/G | 0.76 | 34,111 | 5 | −0.0011 (0.0006) | 0.05 | 25 (0–70) | 0.25 |
| rs11920090 | 3 | SLC2A2 | T/A | 0.83 | 34,033 | 5 | 0.0003 (0.0007) | 0.70 | 42 (0–79) | 0.14 |
| rs2191349 | 7 | DGKB/TMEM195 | T/G | 0.54 | 34,108 | 5 | −0.0002 (0.0005) | 0.71 | 0 (0–79) | 0.47 |
| rs4607517 | 7 | GCK | A/G | 0.21 | 34,333 | 5 | −0.0003 (0.0006) | 0.58 | 34 (0–75) | 0.19 |
| rs11558471 | 8 | SLC30A8 | A/G | 0.70 | 34,150 | 5 | −0.0017 (0.0006) | 0.005 | 0 (0–79) | 0.78 |
| rs7034200 | 9 | GLIS3 | A/C | 0.49 | 33,874 | 5 | 2 × 10−5 (0.0005) | 0.97 | 0 (0–79) | 0.76 |
| rs10885122 | 10 | ADRA2A | G/T | 0.85 | 33,933 | 5 | 0.0002 (0.0008) | 0.75 | 25 (0–70) | 0.25 |
| rs4506565 | 10 | TCF7L2 | T/A | 0.32 | 18,235 | 4 | 0.0002 (0.0005) | 0.71 | 57 (0–86) | 0.07 |
| rs11605924 | 11 | CRY2 | A/C | 0.47 | 34,137 | 5 | 0.0007 (0.0005) | 0.16 | 30 (0–73) | 0.22 |
| rs7944584 | 11 | MADD | A/T | 0.69 | 33,921 | 5 | −0.0004 (0.0006) | 0.44 | 8 (0–81) | 0.36 |
| rs174550 | 11 | FADS1 | T/C | 0.66 | 34,172 | 5 | −0.0005 (0.0005) | 0.33 | 0 (0–79) | 0.82 |
| rs10830963 | 11 | MTNR1B | G/C | 0.28 | 34,009 | 5 | 0.0001 (0.0006) | 0.91 | 48 (0–81) | 0.11 |
| rs11071657 | 15 | C2CD4B | A/G | 0.61 | 33,962 | 5 | 0.0003 (0.0005) | 0.55 | 9 (0–81) | 0.36 |
| Insulin-related | ||||||||||
| rs4675095 | 2 | IRS1 | T/A | 0.06 | 18,241 | 4 | 0.0003 (0.0008) | 0.74 | 0 (0–85) | 0.76 |
| rs35767 | 12 | IGF1 | G/A | 0.81 | 33,888 | 4 | 0.0001 (0.0007) | 0.92 | 0 (0–79) | 0.82 |
| Zinc-related | ||||||||||
| rs10493846 | 1 | SEC63D1 | G/T | 0.74 | 18,158 | 4 | −0.0005 (0.0006) | 0.37 | 0 (0–79) | 0.61 |
| rs11167682 | 5 | SAP30 L | G/T | 0.76 | 18,249 | 5 | 0.0001 (0.0006) | 0.91 | 0 (0–85) | 0.91 |
I2, Higgins heterogeneity index; Q test, Cochran heterogeneity test.
*Estimates for the interaction between total zinc intake (per 1 mg/day from food sources and supplements) and SNPs (per effect allele) on fasting glucose levels (millimoles per liter), adjusted for age and sex, field center (in the CHS and the ARIC study), and family structure by principal components (in the FHS). Boldface values represent P values significant at the conventional level of 0.05.