American Diabetes Association

TABLE 3

Dietary zinc intake and the genetic variants meta-analyzed interactions on fasting glucose levels*

SNP	Chromosome	Nearest gene	Effect/other allele	Effect allele frequency	n	Cohorts	Interaction (total zinc × SNPs) [β (SE)]	Interaction P	I² (%) (95% CI)	Q test P
Glucose-related
rs340874	1	PROX1	C/T	0.52	45,525	14	−0.0007 (0.0009)	0.42	0 (0–55)	0.93
rs780094	2	GCKR	C/T	0.60	45,795	14	−0.0006 (0.0009)	0.52	19 (0–56)	0.25
rs560887	2	G6PC2	C/T	0.70	45,549	14	0.0001 (0.001)	0.90	0 (0–55)	0.79
rs11708067	3	ADCY5	A/G	0.70	45,599	14	−0.0005 (0.0011)	0.65	0 (0–55)	0.45
rs11920090	3	SLC2A2	T/A	0.76	45,521	14	−0.0004 (0.0013)	0.78	30 (0–63)	0.13
rs2191349	7	DGKB/TMEM195	T/G	0.54	45,596	14	−0.0021 (0.0008)	0.01	17 (0–55)	0.27
rs4607517	7	GCK	A/G	0.25	45,821	14	0.0005 (0.0011)	0.68	23 (0–59)	0.21
rs11558471	8	SLC30A8	A/G	0.70	41,994	10	−0.0009 (0.0011)	0.39	0 (0–62)	0.58
rs7034200	9	GLIS3	A/C	0.48	45,362	14	0.0003 (0.0009)	0.68	0 (0–55)	0.59
rs10885122	10	ADRA2A	G/T	0.81	45,421	14	−0.0016 (0.0012)	0.17	14 (0–52)	0.31
rs4506565	10	TCF7L2	T/A	0.32	27,010	10	−0.0004 (0.0010)	0.68	0 (0–62)	0.73
rs11605924	11	CRY2	A/C	0.47	45,625	14	0.0002 (0.0009)	0.78	49 (6–73)	0.019
rs7944584	11	MADD	A/T	0.65	45,409	14	0.0008 (0.0010)	0.44	24 (0–60)	0.20
rs174550	11	FADS1	T/C	0.63	45,660	14	−0.0019 (0.0009)	0.04	26 (0–61)	0.18
rs10830963	11	MTNR1B	G/C	0.28	45,497	14	0.0008 (0.0010)	0.47	34 (0–65)	0.10
rs11071657	15	C2CD4B	A/G	0.59	45,450	14	−0.0002 (0.0009)	0.86	0 (0–55)	0.83
Insulin-related
rs4675095	2	IRS1	T/A	0.07	29,729	13	−0.0006 (0.0019)	0.76	42 (0–70)	0.06
rs35767	12	IGF1	G/A	0.74	45,376	14	−0.0003 (0.0013)	0.83	0 (0–55)	0.47
Zinc-related
rs10493846	1	SEC63D1	G/T	0.74	29,646	13	−0.0008 (0.0011)	0.49	21 (0–59)	0.23
rs11167682	5	SAP30 L	G/T	076	29,737	13	−0.0003 (0.0011)	0.81	0 (0–57)	0.50

SNP	Chromosome	Nearest gene	Effect/other allele	Effect allele frequency	n	Cohorts	Interaction (total zinc × SNPs) [β (SE)]	Interaction P	I² (%) (95% CI)	Q test P
Glucose-related
rs340874	1	PROX1	C/T	0.52	45,525	14	−0.0007 (0.0009)	0.42	0 (0–55)	0.93
rs780094	2	GCKR	C/T	0.60	45,795	14	−0.0006 (0.0009)	0.52	19 (0–56)	0.25
rs560887	2	G6PC2	C/T	0.70	45,549	14	0.0001 (0.001)	0.90	0 (0–55)	0.79
rs11708067	3	ADCY5	A/G	0.70	45,599	14	−0.0005 (0.0011)	0.65	0 (0–55)	0.45
rs11920090	3	SLC2A2	T/A	0.76	45,521	14	−0.0004 (0.0013)	0.78	30 (0–63)	0.13
rs2191349	7	DGKB/TMEM195	T/G	0.54	45,596	14	−0.0021 (0.0008)	0.01	17 (0–55)	0.27
rs4607517	7	GCK	A/G	0.25	45,821	14	0.0005 (0.0011)	0.68	23 (0–59)	0.21
rs11558471	8	SLC30A8	A/G	0.70	41,994	10	−0.0009 (0.0011)	0.39	0 (0–62)	0.58
rs7034200	9	GLIS3	A/C	0.48	45,362	14	0.0003 (0.0009)	0.68	0 (0–55)	0.59
rs10885122	10	ADRA2A	G/T	0.81	45,421	14	−0.0016 (0.0012)	0.17	14 (0–52)	0.31
rs4506565	10	TCF7L2	T/A	0.32	27,010	10	−0.0004 (0.0010)	0.68	0 (0–62)	0.73
rs11605924	11	CRY2	A/C	0.47	45,625	14	0.0002 (0.0009)	0.78	49 (6–73)	0.019
rs7944584	11	MADD	A/T	0.65	45,409	14	0.0008 (0.0010)	0.44	24 (0–60)	0.20
rs174550	11	FADS1	T/C	0.63	45,660	14	−0.0019 (0.0009)	0.04	26 (0–61)	0.18
rs10830963	11	MTNR1B	G/C	0.28	45,497	14	0.0008 (0.0010)	0.47	34 (0–65)	0.10
rs11071657	15	C2CD4B	A/G	0.59	45,450	14	−0.0002 (0.0009)	0.86	0 (0–55)	0.83
Insulin-related
rs4675095	2	IRS1	T/A	0.07	29,729	13	−0.0006 (0.0019)	0.76	42 (0–70)	0.06
rs35767	12	IGF1	G/A	0.74	45,376	14	−0.0003 (0.0013)	0.83	0 (0–55)	0.47
Zinc-related
rs10493846	1	SEC63D1	G/T	0.74	29,646	13	−0.0008 (0.0011)	0.49	21 (0–59)	0.23
rs11167682	5	SAP30 L	G/T	076	29,737	13	−0.0003 (0.0011)	0.81	0 (0–57)	0.50

I², Higgins heterogeneity index; Q test, Cochran heterogeneity test.

*Estimates for the interaction between dietary zinc intake (per 1 mg/day from food sources) and SNPs (per effect allele) on fasting glucose levels (millimoles per liter), adjusted for age and sex, field center (in the CHS, the InCHIANTI study, the ARIC study, and the Health ABC study), and family structure by principal components (in the FHS and the FamHS). Boldface values represent P values significant at the conventional level of 0.05.

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