Combined results from four randomized trials comparing conventional with modified therapy on rates of LGA and SGA infants when low-risk and high-risk fetal abdominal growth is detected before 34 weeks
| . | Conventional therapy . | Modified therapy . | Odds ratio (95% CI)* . |
|---|---|---|---|
| P | |||
| LGA rates | LGA rates | ||
| (1) Not randomized | (1) Not evaluated | ||
| Low-risk fetal | (2) 0/29 | (2) 0/21 | P = 0.86 (Fisher's exact) |
| Abdominal | (3) 2/55 | (3) 2/55 | |
| Circumference* | (4) 2/39 | (4) 4/89 | |
| Total: 4/123 (3.3%) | Total: 6/165 (3.6%) | ||
| High-risk Fetal | (1) 13/29 | (1) 4/30 | OR 0.41 |
| Abdominal | (2) 3/19 | (2) 4/27 | (0.22–0.78) |
| Circumference | (3) 10/42 | (3) 7/36 | P = 0.003 |
| (4) 12/39 | (4) 5/62 | ||
| Total: 38/129 (29.6%) | Total: 20/155 (12.9%) | ||
| Combined LGA rates | 42/252 = 16.7% | 26/320 = 8.1% | OR 0.44 (0.25–0.77) P = 0.0017 |
| SGA rates | SGA rates | ||
| (1) not evaluated | (1) not evaluated | ||
| Low-risk fetal | (2) 3/29 | (2) 0/21 | OR 0.57 (0.28–1.15) P = 0.087 |
| Abdominal | (3) 14/55 | (3) 10/55 | |
| Circumference* | (4) 6/39 | (4) 0/89 | |
| Total: 23/123 = 18.7% | Total: 19/165 = 11.5% | ||
| High-risk fetal | (1) NA | (1) NA | P = 0.41 (Fisher's exact) |
| Abdominal | (2) 0/19 | (2) 0/27 | |
| Circumference | (3) 0/42 | (3) 1/36 | |
| (4) 2/39 | (4) 0/62 | ||
| Total: 2/100 (2.0%) | Total: 1/125 = (0.8%) | ||
| Combined SGA rates | 25/223 = 11.2% | 20/290 = 6.9% | OR 0.59 (0.30–1.13) P = 0.087 |
| . | Conventional therapy . | Modified therapy . | Odds ratio (95% CI)* . |
|---|---|---|---|
| P | |||
| LGA rates | LGA rates | ||
| (1) Not randomized | (1) Not evaluated | ||
| Low-risk fetal | (2) 0/29 | (2) 0/21 | P = 0.86 (Fisher's exact) |
| Abdominal | (3) 2/55 | (3) 2/55 | |
| Circumference* | (4) 2/39 | (4) 4/89 | |
| Total: 4/123 (3.3%) | Total: 6/165 (3.6%) | ||
| High-risk Fetal | (1) 13/29 | (1) 4/30 | OR 0.41 |
| Abdominal | (2) 3/19 | (2) 4/27 | (0.22–0.78) |
| Circumference | (3) 10/42 | (3) 7/36 | P = 0.003 |
| (4) 12/39 | (4) 5/62 | ||
| Total: 38/129 (29.6%) | Total: 20/155 (12.9%) | ||
| Combined LGA rates | 42/252 = 16.7% | 26/320 = 8.1% | OR 0.44 (0.25–0.77) P = 0.0017 |
| SGA rates | SGA rates | ||
| (1) not evaluated | (1) not evaluated | ||
| Low-risk fetal | (2) 3/29 | (2) 0/21 | OR 0.57 (0.28–1.15) P = 0.087 |
| Abdominal | (3) 14/55 | (3) 10/55 | |
| Circumference* | (4) 6/39 | (4) 0/89 | |
| Total: 23/123 = 18.7% | Total: 19/165 = 11.5% | ||
| High-risk fetal | (1) NA | (1) NA | P = 0.41 (Fisher's exact) |
| Abdominal | (2) 0/19 | (2) 0/27 | |
| Circumference | (3) 0/42 | (3) 1/36 | |
| (4) 2/39 | (4) 0/62 | ||
| Total: 2/100 (2.0%) | Total: 1/125 = (0.8%) | ||
| Combined SGA rates | 25/223 = 11.2% | 20/290 = 6.9% | OR 0.59 (0.30–1.13) P = 0.087 |
The results of four randomized trials are designated (1), (2), (3), and (4), from references 21, 22, 23, and 24, respectively.
Odds ratio (95% CIs) and P values were calculated by χ2 test unless otherwise indicated.