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Table 1—

Combined results from four randomized trials comparing conventional with modified therapy on rates of LGA and SGA infants when low-risk and high-risk fetal abdominal growth is detected before 34 weeks

Conventional therapyModified therapyOdds ratio (95% CI)*
   P 
 LGA rates LGA rates  
 (1) Not randomized (1) Not evaluated  
Low-risk fetal (2) 0/29 (2) 0/21 P = 0.86 (Fisher's exact) 
Abdominal (3) 2/55 (3) 2/55  
Circumference* (4) 2/39 (4) 4/89  
 Total: 4/123 (3.3%) Total: 6/165 (3.6%)  
High-risk Fetal (1) 13/29 (1) 4/30 OR 0.41 
Abdominal (2) 3/19 (2) 4/27 (0.22–0.78) 
Circumference (3) 10/42 (3) 7/36 P = 0.003 
 (4) 12/39 (4) 5/62  
 Total: 38/129 (29.6%) Total: 20/155 (12.9%)  
Combined LGA rates 42/252 = 16.7% 26/320 = 8.1% OR 0.44 (0.25–0.77) P = 0.0017 
 SGA rates SGA rates  
 (1) not evaluated (1) not evaluated  
Low-risk fetal (2) 3/29 (2) 0/21 OR 0.57 (0.28–1.15) P = 0.087 
Abdominal (3) 14/55 (3) 10/55  
Circumference* (4) 6/39 (4) 0/89  
 Total: 23/123 = 18.7% Total: 19/165 = 11.5%  
High-risk fetal (1) NA (1) NA P = 0.41 (Fisher's exact) 
Abdominal (2) 0/19 (2) 0/27  
Circumference (3) 0/42 (3) 1/36  
 (4) 2/39 (4) 0/62  
 Total: 2/100 (2.0%) Total: 1/125 = (0.8%)  
Combined SGA rates 25/223 = 11.2% 20/290 = 6.9% OR 0.59 (0.30–1.13) P = 0.087 
Conventional therapyModified therapyOdds ratio (95% CI)*
   P 
 LGA rates LGA rates  
 (1) Not randomized (1) Not evaluated  
Low-risk fetal (2) 0/29 (2) 0/21 P = 0.86 (Fisher's exact) 
Abdominal (3) 2/55 (3) 2/55  
Circumference* (4) 2/39 (4) 4/89  
 Total: 4/123 (3.3%) Total: 6/165 (3.6%)  
High-risk Fetal (1) 13/29 (1) 4/30 OR 0.41 
Abdominal (2) 3/19 (2) 4/27 (0.22–0.78) 
Circumference (3) 10/42 (3) 7/36 P = 0.003 
 (4) 12/39 (4) 5/62  
 Total: 38/129 (29.6%) Total: 20/155 (12.9%)  
Combined LGA rates 42/252 = 16.7% 26/320 = 8.1% OR 0.44 (0.25–0.77) P = 0.0017 
 SGA rates SGA rates  
 (1) not evaluated (1) not evaluated  
Low-risk fetal (2) 3/29 (2) 0/21 OR 0.57 (0.28–1.15) P = 0.087 
Abdominal (3) 14/55 (3) 10/55  
Circumference* (4) 6/39 (4) 0/89  
 Total: 23/123 = 18.7% Total: 19/165 = 11.5%  
High-risk fetal (1) NA (1) NA P = 0.41 (Fisher's exact) 
Abdominal (2) 0/19 (2) 0/27  
Circumference (3) 0/42 (3) 1/36  
 (4) 2/39 (4) 0/62  
 Total: 2/100 (2.0%) Total: 1/125 = (0.8%)  
Combined SGA rates 25/223 = 11.2% 20/290 = 6.9% OR 0.59 (0.30–1.13) P = 0.087 

The results of four randomized trials are designated (1), (2), (3), and (4), from references 21, 22, 23, and 24, respectively.

*

Odds ratio (95% CIs) and P values were calculated by χ2 test unless otherwise indicated.

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