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Table 1—

Insulin secretory defects in knockout models

Pancreatic insulin content (μg/mg pancreas) (2-week-old mice)β-Cell mass (mg) (2-week-old mice)Fasting insulin level (ng/ml)Fed insulin level (ng/ml)Insulin secretion (ng(ng DNA)−1 (60 min)−1) (4-week-old mice)Fasting blood glucose (mg/dl)
Control 0.32 ± 0.06 1.2 ± 0.1 0.4 ± 0.1 1.9 ± 0.4 1.4 ± 0.3 72 ± 13 
βIRKO 0.27 ± 0.05 1.0 ± 0.2 0.9 ± 0.08* 2.6 ± 1.1 1.3 ± 0.2 58 ± 9 
βIGF1RKO 0.35 ± 0.06 0.9 ± 0.4 0.9 ± 0.2* 2.4 ± 0.9 1.3 ± 0.2 82 ± 9 
βDKO 0.11 ± 0.05* 0.5 ± 0.1* Not available 0.6 ± 0.6* 0.2 ± 0.5* 396 ± 102* 
Pancreatic insulin content (μg/mg pancreas) (2-week-old mice)β-Cell mass (mg) (2-week-old mice)Fasting insulin level (ng/ml)Fed insulin level (ng/ml)Insulin secretion (ng(ng DNA)−1 (60 min)−1) (4-week-old mice)Fasting blood glucose (mg/dl)
Control 0.32 ± 0.06 1.2 ± 0.1 0.4 ± 0.1 1.9 ± 0.4 1.4 ± 0.3 72 ± 13 
βIRKO 0.27 ± 0.05 1.0 ± 0.2 0.9 ± 0.08* 2.6 ± 1.1 1.3 ± 0.2 58 ± 9 
βIGF1RKO 0.35 ± 0.06 0.9 ± 0.4 0.9 ± 0.2* 2.4 ± 0.9 1.3 ± 0.2 82 ± 9 
βDKO 0.11 ± 0.05* 0.5 ± 0.1* Not available 0.6 ± 0.6* 0.2 ± 0.5* 396 ± 102* 

Data are compiled from References 10–13.

*

P < 0.05 vs. control mice. βIRKO, β-cell–specific insulin receptor knockout; βIGF1RKO, β-cell–specific IGF-1 receptor knockout; βDKO, β-cell–specific insulin and IGF-1 receptor knockout.

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