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Table 14—

Table of drugs to treat symptomatic DPN

ClassExamplesTypical doses*
Tricyclic drugs Amitriptyline 10–75 mg at bedtime 
 Nortriptyline 25–75 mg at bedtime 
 Imipramine 25–75 mg at bedtime 
Anticonvulsants Gabapentin 300–1,200 mg t.i.d. 
 Carbamazepine 200–400 mg t.i.d. 
 Pregabalin 100 mg t.i.d. 
5-hydroxytryptamine and norepinephrine uptake inhibitor Duloxetine 60–120 mg daily 
Substance P inhibitor Capsaicin cream 0.025–0.075% applied t.i.d. or q.i.d. 
ClassExamplesTypical doses*
Tricyclic drugs Amitriptyline 10–75 mg at bedtime 
 Nortriptyline 25–75 mg at bedtime 
 Imipramine 25–75 mg at bedtime 
Anticonvulsants Gabapentin 300–1,200 mg t.i.d. 
 Carbamazepine 200–400 mg t.i.d. 
 Pregabalin 100 mg t.i.d. 
5-hydroxytryptamine and norepinephrine uptake inhibitor Duloxetine 60–120 mg daily 
Substance P inhibitor Capsaicin cream 0.025–0.075% applied t.i.d. or q.i.d. 
*

Dose response may vary; initial doses should be low and titrated up.

Has FDA indication for treatment of painful diabetic neuropathy.

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