TABLE 2.

Insulin Regimens for GDM and Pregnancy in Patients With Type 2 Diabetes

RegimenDose
Weight-based dosing (10) 0.7–1 units/kg daily in divided doses (no additional recommendations are provided) 
Trimester + weight-based dosing 1st trimester TDD: 0.7 units/kg
2nd trimester TDD: 0.8 units/kg
3rd trimester TDD: 0.9–1 units/kg 
2/3 of TDD given in the morning:
• 1/3 insulin aspart or lispro with breakfast
• 2/3 NPH
1/3 of TDD given in the evening:
• 1/2 insulin aspart or lispro with dinner
• 1/2 NPH before bed 
One-dose-for-all regimen NPH: 20 units in the morning and 20 units at bedtime
Insulin aspart or lispro: 10 units at breakfast and 10 units at dinner 
RegimenDose
Weight-based dosing (10) 0.7–1 units/kg daily in divided doses (no additional recommendations are provided) 
Trimester + weight-based dosing 1st trimester TDD: 0.7 units/kg
2nd trimester TDD: 0.8 units/kg
3rd trimester TDD: 0.9–1 units/kg 
2/3 of TDD given in the morning:
• 1/3 insulin aspart or lispro with breakfast
• 2/3 NPH
1/3 of TDD given in the evening:
• 1/2 insulin aspart or lispro with dinner
• 1/2 NPH before bed 
One-dose-for-all regimen NPH: 20 units in the morning and 20 units at bedtime
Insulin aspart or lispro: 10 units at breakfast and 10 units at dinner 

TDD, total daily dose.

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