Prevalence of autoantibody in relation to rs13266634 genotype
| . | XX . | rs13266634 genotype . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| . | . | CC . | CT . | TT . | P . | |||
| n | 351 | 194 | 127 | 30 | ||||
| Any probe+ | 220 (62.7) | 128 (66.0) | 70 (55.1) | 22 (73.3) | 0.07 | |||
| All probes+ | 107 (30.5) | 63 (32.5) | 37 (29.1) | 7 (23.3) | 0.55 | |||
| Gln probe | 125 (35.6) | 75 (38.7) | 42 (33.1) | 8 (26.7) | 0.33 | |||
| Arg probe | 196 (55.8) | 124 (63.9) | 63 (49.6) | 9 (30.0) | 0.0005 | |||
| Trp probe | 154 (43.9) | 71 (36.6) | 61 (48.0) | 22 (73.3) | 0.0004 | |||
| Gln only | 1 (0.3) | 1 (0.5) | 0 (0.0) | 0 (0.0) | 0.67 | |||
| Arg only | 52 (14.8) | 45 (23.2) | 7 (5.5) | 0 (0.0) | <0.0001 | |||
| Trp only | 18 (5.1) | 1 (0.5) | 5 (3.9) | 12 (40.0) | <0.0001 | |||
| Insulin | 171 (48.7) | 89 (45.9) | 68 (53.5) | 14 (46.7) | 0.39 | |||
| GAD65 | 204 (58.1) | 108 (55.7) | 82 (64.6) | 14 (46.7) | 0.12 | |||
| IA-2 | 254 (72.4) | 144 (74.2) | 88 (69.3) | 22 (73.3) | 0.62 | |||
| . | XX . | rs13266634 genotype . | . | . | . | |||
|---|---|---|---|---|---|---|---|---|
| . | . | CC . | CT . | TT . | P . | |||
| n | 351 | 194 | 127 | 30 | ||||
| Any probe+ | 220 (62.7) | 128 (66.0) | 70 (55.1) | 22 (73.3) | 0.07 | |||
| All probes+ | 107 (30.5) | 63 (32.5) | 37 (29.1) | 7 (23.3) | 0.55 | |||
| Gln probe | 125 (35.6) | 75 (38.7) | 42 (33.1) | 8 (26.7) | 0.33 | |||
| Arg probe | 196 (55.8) | 124 (63.9) | 63 (49.6) | 9 (30.0) | 0.0005 | |||
| Trp probe | 154 (43.9) | 71 (36.6) | 61 (48.0) | 22 (73.3) | 0.0004 | |||
| Gln only | 1 (0.3) | 1 (0.5) | 0 (0.0) | 0 (0.0) | 0.67 | |||
| Arg only | 52 (14.8) | 45 (23.2) | 7 (5.5) | 0 (0.0) | <0.0001 | |||
| Trp only | 18 (5.1) | 1 (0.5) | 5 (3.9) | 12 (40.0) | <0.0001 | |||
| Insulin | 171 (48.7) | 89 (45.9) | 68 (53.5) | 14 (46.7) | 0.39 | |||
| GAD65 | 204 (58.1) | 108 (55.7) | 82 (64.6) | 14 (46.7) | 0.12 | |||
| IA-2 | 254 (72.4) | 144 (74.2) | 88 (69.3) | 22 (73.3) | 0.62 | |||
Data are n (%) unless otherwise indicated. Serum from each type 1 diabetic subject was assayed with ZnT8 C-term probes incorporating Gln, Arg, or Trp at aa325 or insulin, GAD65, or IA-2. P values were calculated by a 3 × 2 Fisher exact test comparing the seropositivitity (index >0.02) to the number of subjects, stratified by rs13266634 genotypes. +, positive.