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TABLE 1

Glucose specific activity during the basal period and the final 30 min of hyperinsulinemic-hypoglycemic clamps in subjects with type 1 diabetes before and after 6 weeks of fluoxetine or placebo administration

Glucose specific activity (dpm/mmol)
−20 min−10 min0 min90 min105 min120 min
Before fluoxetine 364 ± 22 341 ± 25 367 ± 18 273 ± 22 289 ± 13 276 ± 12 
After fluoxetine 334 ± 42 353 ± 33 359 ± 33 262 ± 22 260 ± 20 247 ± 20 
Before placebo 326 ± 18 334 ± 24 338 ± 19 271 ± 22 263 ± 17 259 ± 19 
After placebo 365 ± 24 369 ± 22 376 ± 24 300 ± 20 289 ± 18 272 ± 18 
Glucose specific activity (dpm/mmol)
−20 min−10 min0 min90 min105 min120 min
Before fluoxetine 364 ± 22 341 ± 25 367 ± 18 273 ± 22 289 ± 13 276 ± 12 
After fluoxetine 334 ± 42 353 ± 33 359 ± 33 262 ± 22 260 ± 20 247 ± 20 
Before placebo 326 ± 18 334 ± 24 338 ± 19 271 ± 22 263 ± 17 259 ± 19 
After placebo 365 ± 24 369 ± 22 376 ± 24 300 ± 20 289 ± 18 272 ± 18 

Data are means ± SE.

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