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TABLE 2

Plasma glycerol, lactate, β-hydroxybutyrate, NEFA, and alanine levels during the basal period and the final 30 min of hyperinsulinemic-hypoglycemic clamp studies in type 1 diabetes before and after 6 weeks of fluoxetine or placebo administration

Basal periodFinal 30 min
Glycerol (μmol/l)   
    Before treatment 58 ± 7 65 ± 8 
    After fluoxetine 95 ± 25 110 ± 21* 
    Before treatment 67 ± 15 74 ± 15 
    After placebo 73 ± 11 80 ± 17 
Lactate (mmol/l)   
    Before treatment 0.4 ± 0.04 0.75 ± 0.09 
    After fluoxetine 0.3 ± 0.02 0.83 ± 0.15 
    Before treatment 0.4 ± 0.04 0.75 ± 0.09 
    After placebo 0.4 ± 0.05 0.84 ± 0.00 
β-Hydroxybutyrate (μmol/l)   
    Before treatment 0.099 ± 0.089 0.05 ± 0.03 
    After fluoxetine 0.046 ± 0.026 0.02 ± 0.01 
    Before treatment 0.07 ± 0.004 0.019 ± 0.002 
    After placebo 0.07 ± 0.005 0.02 ± 0.01 
NEFA (μmol/l)   
    Before treatment 149 ± 38 93 ± 24 
    After fluoxetine 165 ± 41 182 ± 64* 
    Before treatment 131 ± 34 86 ± 22 
    After placebo 212 ± 37 91 ± 24 
Alanine (μmol/l)   
    Before treatment 0.23 ± 0.02 0.22 ± 0.02 
    After fluoxetine 0.21 ± 0.02 0.21 ± 0.03 
    Before treatment 0.21 ± 0.02 0.20 ± 0.02 
    After placebo 0.24 ± 0.03 0.22 ± 0.02 
Basal periodFinal 30 min
Glycerol (μmol/l)   
    Before treatment 58 ± 7 65 ± 8 
    After fluoxetine 95 ± 25 110 ± 21* 
    Before treatment 67 ± 15 74 ± 15 
    After placebo 73 ± 11 80 ± 17 
Lactate (mmol/l)   
    Before treatment 0.4 ± 0.04 0.75 ± 0.09 
    After fluoxetine 0.3 ± 0.02 0.83 ± 0.15 
    Before treatment 0.4 ± 0.04 0.75 ± 0.09 
    After placebo 0.4 ± 0.05 0.84 ± 0.00 
β-Hydroxybutyrate (μmol/l)   
    Before treatment 0.099 ± 0.089 0.05 ± 0.03 
    After fluoxetine 0.046 ± 0.026 0.02 ± 0.01 
    Before treatment 0.07 ± 0.004 0.019 ± 0.002 
    After placebo 0.07 ± 0.005 0.02 ± 0.01 
NEFA (μmol/l)   
    Before treatment 149 ± 38 93 ± 24 
    After fluoxetine 165 ± 41 182 ± 64* 
    Before treatment 131 ± 34 86 ± 22 
    After placebo 212 ± 37 91 ± 24 
Alanine (μmol/l)   
    Before treatment 0.23 ± 0.02 0.22 ± 0.02 
    After fluoxetine 0.21 ± 0.02 0.21 ± 0.03 
    Before treatment 0.21 ± 0.02 0.20 ± 0.02 
    After placebo 0.24 ± 0.03 0.22 ± 0.02 

Data are means ± SE. *Significantly increased responses during final 30 min of hypoglycemia after 6 weeks of fluoxetine administration (P < 0.05).

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