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TABLE 3

Cardiovascular responses during hyperinsulinemic-hypoglycemic clamp studies in type 1 diabetes before and after 6 weeks of fluoxetine or placebo administration

Basal periodFinal 30 min
Heart rate (beats/min)   
    Before fluoxetine 69 ± 4 74 ± 5 
    After fluoxetine 69 ± 4 80 ± 4* 
    Before placebo 67 ± 5 67 ± 8 
    After placebo 65 ± 5 69 ± 5 
Systolic blood pressure (mmHg)   
    Before fluoxetine 107 ± 3 113 ± 3 
    After fluoxetine 115 ± 7 127 ± 4* 
    Before placebo 110 ± 3 119 ± 5 
    After placebo 110 ± 4 115 ± 6 
Diastolic blood pressure (mmHg)   
    Before fluoxetine 66 ± 1 61 ± 1 
    After fluoxetine 68 ± 3 67 ± 2* 
    Before placebo 67 ± 3 63 ± 3 
    After placebo 65 ± 3 61 ± 3 
Basal periodFinal 30 min
Heart rate (beats/min)   
    Before fluoxetine 69 ± 4 74 ± 5 
    After fluoxetine 69 ± 4 80 ± 4* 
    Before placebo 67 ± 5 67 ± 8 
    After placebo 65 ± 5 69 ± 5 
Systolic blood pressure (mmHg)   
    Before fluoxetine 107 ± 3 113 ± 3 
    After fluoxetine 115 ± 7 127 ± 4* 
    Before placebo 110 ± 3 119 ± 5 
    After placebo 110 ± 4 115 ± 6 
Diastolic blood pressure (mmHg)   
    Before fluoxetine 66 ± 1 61 ± 1 
    After fluoxetine 68 ± 3 67 ± 2* 
    Before placebo 67 ± 3 63 ± 3 
    After placebo 65 ± 3 61 ± 3 

Data are means ± SE.

*

Significantly increased responses during final 30 min of hypoglycemia after 6 weeks of fluoxetine administration (P < 0.05).

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