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TABLE 2

Binding of preproinsulin peptides to selected HLA class I alleles

Peptide*SequenceHLA IHLA motifAnchoring fitBinding§
Type of binder
10−410−6
1–8 MALWMRLL A2 MALWMRLL 46 
2–11 ALWMRLLPLL A2 ALWMRLLPLL ++ 55 53 
  A24 ALWMRLLPLL 80 100 
  B8 ALWMRLLPLL 24 20 
6–14 RLLPLLALL A2 RLLPLLALL ++ 36 65 
6–16 RLLPLLALLAL A2 RLLPLLALLAL ++ 96 71 
14–23 LALWGPDPAA A2 LALWGPDPAA 44 36 
15–24 ALWGPDPAAA A2 ALWGPDPAAA 96 94 
15–25 ALWGPDPAAAF A1 ALWGPDPAAAF 18 41 
  A24 ALWGPDPAAAF ++ 82 100 
Peptide*SequenceHLA IHLA motifAnchoring fitBinding§
Type of binder
10−410−6
1–8 MALWMRLL A2 MALWMRLL 46 
2–11 ALWMRLLPLL A2 ALWMRLLPLL ++ 55 53 
  A24 ALWMRLLPLL 80 100 
  B8 ALWMRLLPLL 24 20 
6–14 RLLPLLALL A2 RLLPLLALL ++ 36 65 
6–16 RLLPLLALLAL A2 RLLPLLALLAL ++ 96 71 
14–23 LALWGPDPAA A2 LALWGPDPAA 44 36 
15–24 ALWGPDPAAA A2 ALWGPDPAAA 96 94 
15–25 ALWGPDPAAAF A1 ALWGPDPAAAF 18 41 
  A24 ALWGPDPAAAF ++ 82 100 

Data are percent.

*

NH2- and COOH-terminal positions in preproinsulin.

Anchoring positions are in bold characters.

HLA anchoring motifs: ++, strict; +, tolerated.

§

Binding (%) = binding of tested peptide/binding of viral reference peptide.

L, low binder (binding <20% at 10−6 mol/l and binding >20% at 10−4 mol/l); I, intermediate binder (binding between 20 and 50% at 10−6 mol/l); H, high binder (binding >50% at 10−6 mol/l).

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