American Diabetes Association

TABLE 3

Recognition of viral peptides by PBMCs of patients and of control individuals

V^*	Epitope	Sequence	HLA^†	Frequencies of recognition^‡			Responses^§
V^*	Epitope	Sequence	HLA^†					Patients	Control subjects	Patients	Control subjects	Comparison (P)
IV	M0. 58–66	GILGFVFTL	A2	18/20	8/11	89 (0–676)	49 (0–246)	0.36
IV	NP 44–52	CTELKLSDY	A1	3/6	3/3	39 (7–40)	14 (10–20)	0.43
IV	NP 380–388	ELRSRYWAI	B8	7/13	2/7	8 (0–119)	5 (2–131)	0.30
HIV	Nef 83–91	AAVDLSHFL	A2	0/12	0/4	3 (0–20)	0 (0–5)	0.06
HIV	Nef 182–189	EWRFDSRLA	B8	0/8	0/3	1 (0–35)	0 (0–0)	0.07

V^*	Epitope	Sequence	HLA^†	Frequencies of recognition^‡			Responses^§
V^*	Epitope	Sequence	HLA^†					Patients	Control subjects	Patients	Control subjects	Comparison (P)
IV	M0. 58–66	GILGFVFTL	A2	18/20	8/11	89 (0–676)	49 (0–246)	0.36
IV	NP 44–52	CTELKLSDY	A1	3/6	3/3	39 (7–40)	14 (10–20)	0.43
IV	NP 380–388	ELRSRYWAI	B8	7/13	2/7	8 (0–119)	5 (2–131)	0.30
HIV	Nef 83–91	AAVDLSHFL	A2	0/12	0/4	3 (0–20)	0 (0–5)	0.06
HIV	Nef 182–189	EWRFDSRLA	B8	0/8	0/3	1 (0–35)	0 (0–0)	0.07

Data are n or median (mean).

V, virus; IV, influenza virus.

†

HLA, presenting HLA molecule.

‡

ELISpot responses, number of responders/number of individuals tested.

Median (range) of stimulation score; stimulation score = mean number of spots in response to peptide − mean number of spots in absence of peptide; P, P values comparing the median responses in patients versus control subjects; nonparametric Mann-Whitney test.

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