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TABLE 5

Recognition of preproinsulin peptides by PBMCs of diabetic patients: median values of stimulation score

P*HLAResponses
Comparison
LRCDPatientsControl subjectsP value
2–11 A2 3.3 (0–12.2) 10.0 (0–41.8) 0.56 (0–8.3) 0 (0–0) 7.8 (0–41.8) 0 (0–8.3) 0.01 
 A24 5.2 (2.2–12.2) 0 (0–41.8) — — 2.8 (0–41.8) — — 
 B8 25 (0–105) 8.2 (0–37.2) 0 (0–1.1) 0 (0–5.6) 15.6 (0–105) 0 (0–5.6) 0.01 
6–16 A2 12.2 (10–54.5) 5 (0–111.7) 0 (0–9.5) 0 (0–0) 7.3 (0–111.7) 0 (0–9.5) 0.004 
6–14 A2 28.9 (21.1–51.1) 30.6 (7.8–144) 4.7 (3.9–7.2) — 30.6 (7.8–144) 4.7 (3.9–7.2) 0.01 
14–23 A2 11.1 (7.8–12.2) 7.7 (54–0) 1.4 (0–5.6) — 8.9 (54–0) 1.4 (0–5.6) 0.04 
15–24 A2 12.8 (2.4–32.2) 8.7 (0–52.8) 0 (0–0) — 12.2 (0–52.8) 0 (0–0) 0.002 
15–25 A1 13.6 (6.1–25.6) 1.7 (0–14.4) — — 9.2 (0–25.6) — — 
 A24 11.1 (5.8–25.6) 0 (0–14.4) — — 0 (0–25.6) — — 
P*HLAResponses
Comparison
LRCDPatientsControl subjectsP value
2–11 A2 3.3 (0–12.2) 10.0 (0–41.8) 0.56 (0–8.3) 0 (0–0) 7.8 (0–41.8) 0 (0–8.3) 0.01 
 A24 5.2 (2.2–12.2) 0 (0–41.8) — — 2.8 (0–41.8) — — 
 B8 25 (0–105) 8.2 (0–37.2) 0 (0–1.1) 0 (0–5.6) 15.6 (0–105) 0 (0–5.6) 0.01 
6–16 A2 12.2 (10–54.5) 5 (0–111.7) 0 (0–9.5) 0 (0–0) 7.3 (0–111.7) 0 (0–9.5) 0.004 
6–14 A2 28.9 (21.1–51.1) 30.6 (7.8–144) 4.7 (3.9–7.2) — 30.6 (7.8–144) 4.7 (3.9–7.2) 0.01 
14–23 A2 11.1 (7.8–12.2) 7.7 (54–0) 1.4 (0–5.6) — 8.9 (54–0) 1.4 (0–5.6) 0.04 
15–24 A2 12.8 (2.4–32.2) 8.7 (0–52.8) 0 (0–0) — 12.2 (0–52.8) 0 (0–0) 0.002 
15–25 A1 13.6 (6.1–25.6) 1.7 (0–14.4) — — 9.2 (0–25.6) — — 
 A24 11.1 (5.8–25.6) 0 (0–14.4) — — 0 (0–25.6) — — 

Data are median (range). P, peptide; R, recent-onset diabetes; L, long-standing diabetes; C, healthy control subjects; D, type 2 diabetic control subjects.

*

NH2- and COOH-terminal amino acids in preproinsulin.

ELISpot responses; median (range) of stimulation score; stimulation score = mean number of spots in response to peptide − mean number of spots in absence of peptide.

P values comparing the median responses in patients versus control subjects; nonparametric Mann-Whitney test.

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