American Diabetes Association

TABLE 2

Diabetes incidence adjusted for ethnicity

Marker SNP	Gene region	Alleles^*	Interaction^†	Overall			Placebo			Lifestyle			Metformin
Marker SNP	Gene region	Alleles^*	Interaction^†					HR (95% CI)^‡	P value	HR (95% CI)^‡	P value	HR (95% CI)^‡	P value	HR (95% CI)^‡	P value
rs1111875	HHEX	C/T	No	1.03 (0.92–1.16)	0.59	0.93 (0.78–1.11)	0.44	1.07 (0.84–1.37)	0.58	1.20 (0.97–1.48)	0.10
rs7923837	HHEX	G/A	No	1.02 (0.90–1.16)	0.71	1.03 (0.85–1.24)	0.78	0.92 (0.71–1.20)	0.55	1.13 (0.91–1.41)	0.28
rs11037909	EXT2	T/C	No	1.02 (0.90–1.16)	0.76	0.95 (0.78–1.16)	0.59	1.02 (0.78–1.34)	0.89	1.14 (0.91–1.43)	0.27
rs1113132	EXT2	C/G	No	1.02 (0.89–1.16)	0.81	0.95 (0.78–1.15)	0.61	0.98 (0.75–1.28)	0.88	1.14 (0.92–1.43)	0.23
rs3740878	EXT2	T/C	No	1.02 (0.91–1.15)	0.71	0.95 (0.78–1.16)	0.63	1.03 (0.78–1.35)	0.85	1.13 (0.90–1.42)	0.30
rs13266634	SLC30A8	C/T	No	0.96 (0.84–1.10)	0.60	1.00 (0.81–1.23)	0.99	1.13 (0.87–1.47)	0.37	0.82 (0.64–1.05)	0.12
rs7480010	LOC387761	G/A	No	1.02 (0.90–1.17)	0.72	1.00 (0.82–1.22)	1.00	0.99 (0.76–1.30)	0.95	1.07 (0.85–1.34)	0.56
rs10811661	CDKN2A/B	T/C	Yes			1.22 (0.96–1.54)	0.11	0.94 (0.67–1.32)	0.74	0.81 (0.59–1.12)	0.20
rs1470579	IGF2BP2	C/A	No	1.05 (0.94–1.19)	0.39	0.91 (0.75–1.09)	0.30	1.13 (0.88–1.44)	0.33	1.21 (0.99–1.49)	0.07
rs7754840	CDKAL1	C/G	No	1.02 (0.91–1.15)	0.71	1.07 (0.90–1.27)	0.46	0.89 (0.69–1.15)	0.37	1.04 (0.85–1.28)	0.69

Marker SNP	Gene region	Alleles^*	Interaction^†	Overall			Placebo			Lifestyle			Metformin
Marker SNP	Gene region	Alleles^*	Interaction^†					HR (95% CI)^‡	P value	HR (95% CI)^‡	P value	HR (95% CI)^‡	P value	HR (95% CI)^‡	P value
rs1111875	HHEX	C/T	No	1.03 (0.92–1.16)	0.59	0.93 (0.78–1.11)	0.44	1.07 (0.84–1.37)	0.58	1.20 (0.97–1.48)	0.10
rs7923837	HHEX	G/A	No	1.02 (0.90–1.16)	0.71	1.03 (0.85–1.24)	0.78	0.92 (0.71–1.20)	0.55	1.13 (0.91–1.41)	0.28
rs11037909	EXT2	T/C	No	1.02 (0.90–1.16)	0.76	0.95 (0.78–1.16)	0.59	1.02 (0.78–1.34)	0.89	1.14 (0.91–1.43)	0.27
rs1113132	EXT2	C/G	No	1.02 (0.89–1.16)	0.81	0.95 (0.78–1.15)	0.61	0.98 (0.75–1.28)	0.88	1.14 (0.92–1.43)	0.23
rs3740878	EXT2	T/C	No	1.02 (0.91–1.15)	0.71	0.95 (0.78–1.16)	0.63	1.03 (0.78–1.35)	0.85	1.13 (0.90–1.42)	0.30
rs13266634	SLC30A8	C/T	No	0.96 (0.84–1.10)	0.60	1.00 (0.81–1.23)	0.99	1.13 (0.87–1.47)	0.37	0.82 (0.64–1.05)	0.12
rs7480010	LOC387761	G/A	No	1.02 (0.90–1.17)	0.72	1.00 (0.82–1.22)	1.00	0.99 (0.76–1.30)	0.95	1.07 (0.85–1.34)	0.56
rs10811661	CDKN2A/B	T/C	Yes			1.22 (0.96–1.54)	0.11	0.94 (0.67–1.32)	0.74	0.81 (0.59–1.12)	0.20
rs1470579	IGF2BP2	C/A	No	1.05 (0.94–1.19)	0.39	0.91 (0.75–1.09)	0.30	1.13 (0.88–1.44)	0.33	1.21 (0.99–1.49)	0.07
rs7754840	CDKAL1	C/G	No	1.02 (0.91–1.15)	0.71	1.07 (0.90–1.27)	0.46	0.89 (0.69–1.15)	0.37	1.04 (0.85–1.28)	0.69

*

Risk allele listed first.

†

Genotype by treatment interaction(Yes if P < 0.05).

‡

Hazard ratio(HR) and 95% CI by genotype and treatment group.