American Diabetes Association

TABLE 3

Baseline quantitative traits adjusted for ethnicity

SNP	Gene region	Alleles^*	Trait	High-risk genotype	Heterozygote	Low-risk genotype	P value
rs79238327	HHEX	G/A	ISI	0.155 (0.149–0.162)	0.163 (0.156–0.169)	0.160 (0.151–0.169)	0.11
			Ins Index	1.22 (1.16–1.28)	1.25 (1.19–1.31)	1.28 (1.19–1.36)	0.39
rs1111875	HHEX	C/T	ISI	0.156 (0.149–0.162)	0.163 (0.157–0.170)	0.158 (0.150–0.167)	0.08
			Ins Index	1.20 (1.14–1.26)	1.24 (1.19–1.30)	1.33 (1.24–1.41)	0.01
rs1113132	EXT2	C/G	ISI	0.165 (0.156–0.175)	0.158 (0.152–0.164)	0.159 (0.152–0.165)	0.27
			Ins Index	1.18 (1.10–1.26)	1.24 (1.18–1.30)	1.28 (1.22–1.34)	0.07
rs11037909	EXT2	T/C	ISI	0.160 (0.153–0.167)	0.162 (0.155–0.169)	0.153 (0.144–0.163)	0.26
			Ins Index	1.23 (1.17–1.30)	1.23 (1.17–1.30)	1.29 (1.20–1.39)	0.47
rs3740878	EXT2	T/C	ISI	0.159 (0.153–0.166)	0.163 (0.156–0.170)	0.153 (0.144–0.163)	0.19
			Ins Index	1.22 (1.16–1.28)	1.23 (1.17–1.29)	1.32 (1.23–1.42)	0.14
rs13266634	SLC30A8	C/T	ISI	0.162 (0.157–0.168)	0.156 (0.149–0.162)	0.154 (0.143–0.167)	0.09
			Ins Index	1.22 (1.16–1.27)	1.27 (1.21–1.33)	1.32 (1.20–1.44)	0.09
rs7480010	LOC387761	G/A	ISI	0.164 (0.155–0.174)	0.158 (0.151–0.164)	0.159 (0.152–0.165)	0.47
			Ins Index	1.26 (1.20–1.32)	1.23 (1.16–1.29)	1.24 (1.15–1.33)	0.55
rs10811661	CDKN2A/B	T/C	ISI	0.161 (0.155–0.167)	0.157 (0.149–0.164)	0.143 (0.126–0.161)	0.09
			Ins Index	1.24 (1.19–1.29)	1.25 (1.18–1.32)	1.28 (1.10–1.47)	0.91
rs1470579	IGF2BP2	C/A	ISI	0.159 (0.151–0.168)	0.163 (0.156–0.169)	0.157 (0.151–0.163)	0.26
			Ins Index	1.23 (1.15–1.31)	1.22 (1.16–1.28)	1.27 (1.21–1.33)	0.33
rs7754840	CDKAL1	C/G	ISI	0.165 (0.156–0.175)	0.158 (0.152–0.164)	0.159 (0.152–0.165)	0.27
			Ins Index	1.18 (1.10–1.26)	1.24 (1.18–1.30)	1.28 (1.22–1.34)	0.07

SNP	Gene region	Alleles^*	Trait	High-risk genotype	Heterozygote	Low-risk genotype	P value
rs79238327	HHEX	G/A	ISI	0.155 (0.149–0.162)	0.163 (0.156–0.169)	0.160 (0.151–0.169)	0.11
			Ins Index	1.22 (1.16–1.28)	1.25 (1.19–1.31)	1.28 (1.19–1.36)	0.39
rs1111875	HHEX	C/T	ISI	0.156 (0.149–0.162)	0.163 (0.157–0.170)	0.158 (0.150–0.167)	0.08
			Ins Index	1.20 (1.14–1.26)	1.24 (1.19–1.30)	1.33 (1.24–1.41)	0.01
rs1113132	EXT2	C/G	ISI	0.165 (0.156–0.175)	0.158 (0.152–0.164)	0.159 (0.152–0.165)	0.27
			Ins Index	1.18 (1.10–1.26)	1.24 (1.18–1.30)	1.28 (1.22–1.34)	0.07
rs11037909	EXT2	T/C	ISI	0.160 (0.153–0.167)	0.162 (0.155–0.169)	0.153 (0.144–0.163)	0.26
			Ins Index	1.23 (1.17–1.30)	1.23 (1.17–1.30)	1.29 (1.20–1.39)	0.47
rs3740878	EXT2	T/C	ISI	0.159 (0.153–0.166)	0.163 (0.156–0.170)	0.153 (0.144–0.163)	0.19
			Ins Index	1.22 (1.16–1.28)	1.23 (1.17–1.29)	1.32 (1.23–1.42)	0.14
rs13266634	SLC30A8	C/T	ISI	0.162 (0.157–0.168)	0.156 (0.149–0.162)	0.154 (0.143–0.167)	0.09
			Ins Index	1.22 (1.16–1.27)	1.27 (1.21–1.33)	1.32 (1.20–1.44)	0.09
rs7480010	LOC387761	G/A	ISI	0.164 (0.155–0.174)	0.158 (0.151–0.164)	0.159 (0.152–0.165)	0.47
			Ins Index	1.26 (1.20–1.32)	1.23 (1.16–1.29)	1.24 (1.15–1.33)	0.55
rs10811661	CDKN2A/B	T/C	ISI	0.161 (0.155–0.167)	0.157 (0.149–0.164)	0.143 (0.126–0.161)	0.09
			Ins Index	1.24 (1.19–1.29)	1.25 (1.18–1.32)	1.28 (1.10–1.47)	0.91
rs1470579	IGF2BP2	C/A	ISI	0.159 (0.151–0.168)	0.163 (0.156–0.169)	0.157 (0.151–0.163)	0.26
			Ins Index	1.23 (1.15–1.31)	1.22 (1.16–1.28)	1.27 (1.21–1.33)	0.33
rs7754840	CDKAL1	C/G	ISI	0.165 (0.156–0.175)	0.158 (0.152–0.164)	0.159 (0.152–0.165)	0.27
			Ins Index	1.18 (1.10–1.26)	1.24 (1.18–1.30)	1.28 (1.22–1.34)	0.07

Data are least squares means(95% CI).

Risk allele listed first. ISI is expressed as [(μU/ml) ×(mmol/l)]⁻¹; Ins Index, insulinogenic index expressed as [(μU/ml)/(mg/dl)].

View Large

This Feature Is Available To Subscribers Only