Follow-up quantitative traits adjusted for ethnicity
| . | . | Placebo . | . | Lifestyle . | . | Metformin . | . | Troglitazone . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | Least squares mean (95% CI) . | P value . | Least squares mean (95% CI) . | P value . | Least squares mean (95% CI) . | P value . | Least squares mean (95% CI) . | P value . | ||||
| rs79238327, HHEX ISI | |||||||||||||
| GG | 0.154 (0.143–0.165) | 0.68 | 0.202 (0.188–0.218) | 0.18 | 0.194 (0.181–0.208) | 0.10 | 0.212 (0.169–0.266) | 0.02 | |||||
| AG | 0.157 (0.147–0.167) | 0.210 (0.196–0.225) | 0.190 (0.177–0.204) | 0.182 (0.144–0.230) | |||||||||
| AA | 0.150 (0.137–0.165) | 0.226 (0.203–0.251) | 0.173 (0.158–0.191) | 0.171 (0.130–0.223) | |||||||||
| Ins Index | GG | 1.19 (1.07–1.31) | 0.45 | 1.15 (1.04–1.27) | 0.32 | 1.13 (1.03–1.24) | 0.90 | 1.09 (0.94–1.24) | 0.76 | ||||
| AG | 1.26 (1.15–1.38) | 1.19 (1.08–1.30) | 1.11 (1.01–1.22) | 1.12 (0.97–1.28) | |||||||||
| AA | 1.26 (1.10–1.43) | 1.06 (0.90–1.22) | 1.13 (0.99–1.28) | 1.03 (0.81–1.26) | |||||||||
| rs1111875, HHEX ISI | |||||||||||||
| CC | 0.155 (0.145–0.166) | 0.79 | 0.206 (0.191–0.221) | 0.69 | 0.195 (0.182–0.209) | 0.19 | 0.206 (0.164–0.259) | 0.07 | |||||
| CT | 0.153 (0.144–0.163) | 0.212 (0.198–0.227) | 0.187 (0.175–0.200) | 0.196 (0.156–0.248) | |||||||||
| TT | 0.158 (0.144–0.172) | 0.214 (0.193–0.236) | 0.179 (0.164–0.196) | 0.167 (0.129–0.217) | |||||||||
| Ins Index | CC | 1.18 (1.06–1.30) | 0.31 | 1.14 (1.02–1.25) | 0.32 | 1.15 (1.04–1.26) | 0.26 | 1.08 (0.93–1.24) | 0.96 | ||||
| CT | 1.28 (1.17–1.39) | 1.19 (1.09–1.30) | 1.15 (1.05–1.26) | 1.08 (0.94–1.23) | |||||||||
| TT | 1.23 (1.08–1.39) | 1.08 (0.93–1.23) | 1.03 (0.90–1.17) | 1.11 (0.91–1.33) | |||||||||
| rs11037909, EXT2 ISI | TT | 0.150 (0.140–0.161) | 0.46 | 0.213 (0.198–0.230) | 0.58 | 0.190 (0.178–0.204) | 0.05 | 0.185 (0.146–0.234) | 0.33 | ||||
| CT | 0.157 (0.147–0.168) | 0.205 (0.191–0.220) | 0.195 (0.182–0.209) | 0.188 (0.147–0.239) | |||||||||
| CC | 0.157 (0.142–0.172) | 0.213 (0.191–0.238) | 0.169 (0.152–0.188) | 0.220 (0.167–0.289) | |||||||||
| Ins Index | TT | 1.25 (1.13–1.37) | 0.74 | 1.09 (0.98–1.20) | 0.18 | 1.13 (1.03–1.24) | 0.86 | 1.07 (0.93–1.21) | 0.31 | ||||
| CT | 1.21 (1.09–1.33) | 1.20 (1.09–1.31) | 1.11 (1.00–1.21) | 1.05 (0.90–1.20) | |||||||||
| CC | 1.26 (1.10–1.43) | 1.18 (1.01–1.35) | 1.14 (0.98–1.31) | 1.29 (1.00–1.60) | |||||||||
| rs1113132, EXT2 ISI | CC | 0.159 (0.145–0.175) | 0.18 | 0.219 (0.198–0.242) | 0.57 | 0.194 (0.176–0.214) | 0.51 | 0.209 (0.163–0.267) | 0.31 | ||||
| CG | 0.149 (0.140–0.159) | 0.207 (0.194–0.222) | 0.190 (0.178–0.203) | 0.184 (0.146–0.232) | |||||||||
| GG | 0.158 (0.148–0.169) | 0.211 (0.196–0.227) | 0.184 (0.172–0.197) | 0.196 (0.154–0.248) | |||||||||
| Ins Index | CC | 1.29 (1.13–1.46) | 0.70 | 1.05 (0.90–1.21) | 0.11 | 1.09 (0.95–1.24) | 0.67 | 1.15 (0.94–1.38) | 0.77 | ||||
| CG | 1.22 (1.11–1.33) | 1.13 (1.03–1.23) | 1.11 (1.01–1.21) | 1.07 (0.93–1.21) | |||||||||
| GG | 1.23 (1.11–1.35) | 1.22 (1.11–1.34) | 1.15 (1.04–1.25) | 1.08 (0.92–1.23) | |||||||||
| rs3740878, EXT2 ISI | TT | 0.151 (0.141–0.162) | 0.44 | 0.214 (0.199–0.230) | 0.54 | 0.190 (0.177–0.203) | 0.15 | 0.184 (0.145–0.233) | 0.32 | ||||
| CT | 0.158 (0.148–0.169) | 0.205 (0.190–0.220) | 0.194 (0.181–0.208) | 0.189 (0.148–0.240) | |||||||||
| CC | 0.154 (0.140–0.170) | 0.211 (0.189–0.237) | 0.172 (0.154–0.192) | 0.220 (0.167–0.289) | |||||||||
| Ins Index | TT | 1.27 (1.15–1.40) | 0.65 | 1.09 (0.98–1.20) | 0.17 | 1.15 (1.05–1.26) | 0.30 | 1.09 (0.96–1.23) | 0.21 | ||||
| CT | 1.22 (1.10–1.34) | 1.20 (1.08–1.31) | 1.08 (0.97–1.18) | 1.02 (0.87–1.17) | |||||||||
| CC | 1.20 (1.04–1.37) | 1.20 (1.03–1.38) | 1.17 (1.00–1.34) | 1.29 (1.00–1.60) | |||||||||
| rs13266634, SLC30A8 ISI | |||||||||||||
| CC | 0.155 (0.146–0.164) | 0.54 | 0.206 (0.193–0.220) | 0.45 | 0.188 (0.176–0.200) | 0.91 | 0.208 (0.165–0.262) | 0.19 | |||||
| CT | 0.152 (0.142–0.163) | 0.214 (0.199–0.230) | 0.189 (0.176–0.203) | 0.186 (0.147–0.234) | |||||||||
| TT | 0.165 (0.143–0.190) | 0.222 (0.194–0.255) | 0.184 (0.160–0.212) | 0.185 (0.136–0.250) | |||||||||
| Ins Index | CC | 1.26 (1.16–1.36) | 0.36 | 1.11 (1.01–1.21) | 0.22 | 1.10 (1.01–1.20) | 0.16 | 1.09 (0.96–1.22) | 0.90 | ||||
| CT | 1.21 (1.10–1.34) | 1.21 (1.10–1.33) | 1.13 (1.02–1.24) | 1.07 (0.91–1.23) | |||||||||
| TT | 1.09 (0.85–1.34) | 1.11 (0.91–1.32) | 1.30 (1.09–1.53) | 1.14 (0.85–1.46) | |||||||||
| rs7480010, LOC387761 ISI | |||||||||||||
| GG | 0.157 (0.142–0.173) | 0.59 | 0.204 (0.183–0.227) | 0.83 | 0.176 (0.161–0.194) | 0.21 | 0.188 (0.144–0.246) | 0.89 | |||||
| GA | 0.157 (0.147–0.168) | 0.211 (0.195–0.227) | 0.193 (0.179–0.207) | 0.197 (0.155–0.250) | |||||||||
| AA | 0.152 (0.142–0.162) | 0.212 (0.198–0.227) | 0.190 (0.177–0.204) | 0.197 (0.156–0.248) | |||||||||
| Ins Index | GG | 1.34 (1.17–1.52) | 0.26 | 1.17 (1.00–1.34) | 0.98 | 1.15 (1.01–1.30) | 0.89 | 1.11 (0.89–1.34) | 0.79 | ||||
| GA | 1.24 (1.12–1.37) | 1.15 (1.03–1.27) | 1.12 (1.01–1.23) | 1.05 (0.90–1.21) | |||||||||
| AA | 1.18 (1.07–1.30) | 1.15 (1.05–1.26) | 1.11 (1.01–1.22) | 1.10 (0.95–1.26) | |||||||||
| rs10811661, CDKN2A/B ISI | |||||||||||||
| TT | 0.154 (0.146–0.163) | 0.68 | 0.207 (0.195–0.220) | 0.13 | 0.190 (0.179–0.202) | 0.15 | 0.197 (0.156–0.247) | 0.96 | |||||
| CT | 0.152 (0.140–0.165) | 0.215 (0.198–0.234) | 0.189 (0.174–0.205) | 0.193 (0.152–0.245) | |||||||||
| CC | 0.167 (0.135–0.205) | 0.257 (0.206–0.320) | 0.153 (0.123–0.190) | 0.199 (0.134–0.294) | |||||||||
| Ins Index | TT | 1.23 (1.13–1.33) | 0.46 | 1.18 (1.09–1.28) | 0.05 | 1.46 (1.12–1.83) | 0.12 | 1.01 (0.88–1.13) | 0.01 | ||||
| CT | 1.29 (1.14–1.43) | 1.04 (0.92–1.17) | 1.09 (0.97–1.21) | 1.12 (0.94–1.31) | |||||||||
| CC | 1.06 (0.72–1.44) | 1.30 (0.96–1.67) | 1.12 (1.02–1.21) | 1.71 (1.24–2.22) | |||||||||
| rs1470579, IGF2BP2 | |||||||||||||
| ISI | CC | 0.161 (0.147–0.177) | 0.52 | 0.225 (0.204–0.247) | 0.02 | 0.198 (0.181–0.216) | 0.32 | 0.191 (0.147–0.248) | 0.31 | ||||
| AC | 0.152 (0.142–0.163) | 0.217 (0.202–0.234) | 0.187 (0.175–0.200) | 0.185 (0.146–0.234) | |||||||||
| AA | 0.154 (0.144–0.164) | 0.197 (0.184–0.212) | 0.184 (0.172–0.198) | 0.205 (0.162–0.258) | |||||||||
| Ins Index | CC | 1.17 (1.01–1.34) | 0.55 | 1.07 (0.93–1.21) | 0.03 | 1.12 (1.02–1.23) | 0.84 | 1.20 (1.00–1.42) | 0.17 | ||||
| AC | 1.26 (1.15–1.39) | 1.10 (0.99–1.21) | 1.11 (1.01–1.21) | 0.99 (0.84–1.14) | |||||||||
| AA | 1.23 (1.12–1.35) | 1.25 (1.14–1.37) | 1.15 (1.02–1.29) | 1.09 (0.93–1.25) | |||||||||
| rs7754840, | |||||||||||||
| CDKAL1 ISI | CC | 0.159 (0.145–0.175) | 0.18 | 0.219 (0.198–0.242) | 0.57 | 0.194 (0.176–0.214) | 0.51 | 0.209 (0.163–0.267) | 0.31 | ||||
| CG | 0.149 (0.140–0.159) | 0.207 (0.194–0.222) | 0.190 (0.178–0.203) | 0.184 (0.146–0.232) | |||||||||
| GG | 0.158 (0.148–0.169) | 0.211 (0.196–0.227) | 0.184 (0.172–0.197) | 0.196 (0.154–0.248) | |||||||||
| Ins Index | CC | 1.29 (1.13–1.46) | 0.70 | 1.05 (0.90–1.21) | 0.11 | 1.09 (0.95–1.24) | 0.67 | 1.15 (0.94–1.38) | 0.77 | ||||
| CG | 1.22 (1.11–1.33) | 1.13 (1.03–1.23) | 1.11 (1.01–1.21) | 1.07 (0.93–1.21) | |||||||||
| GG | 1.23 (1.11–1.35) | 1.22 (1.11–1.34) | 1.15 (1.04–1.25) | 1.08 (0.92–1.23) | |||||||||
| . | . | Placebo . | . | Lifestyle . | . | Metformin . | . | Troglitazone . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | . | Least squares mean (95% CI) . | P value . | Least squares mean (95% CI) . | P value . | Least squares mean (95% CI) . | P value . | Least squares mean (95% CI) . | P value . | ||||
| rs79238327, HHEX ISI | |||||||||||||
| GG | 0.154 (0.143–0.165) | 0.68 | 0.202 (0.188–0.218) | 0.18 | 0.194 (0.181–0.208) | 0.10 | 0.212 (0.169–0.266) | 0.02 | |||||
| AG | 0.157 (0.147–0.167) | 0.210 (0.196–0.225) | 0.190 (0.177–0.204) | 0.182 (0.144–0.230) | |||||||||
| AA | 0.150 (0.137–0.165) | 0.226 (0.203–0.251) | 0.173 (0.158–0.191) | 0.171 (0.130–0.223) | |||||||||
| Ins Index | GG | 1.19 (1.07–1.31) | 0.45 | 1.15 (1.04–1.27) | 0.32 | 1.13 (1.03–1.24) | 0.90 | 1.09 (0.94–1.24) | 0.76 | ||||
| AG | 1.26 (1.15–1.38) | 1.19 (1.08–1.30) | 1.11 (1.01–1.22) | 1.12 (0.97–1.28) | |||||||||
| AA | 1.26 (1.10–1.43) | 1.06 (0.90–1.22) | 1.13 (0.99–1.28) | 1.03 (0.81–1.26) | |||||||||
| rs1111875, HHEX ISI | |||||||||||||
| CC | 0.155 (0.145–0.166) | 0.79 | 0.206 (0.191–0.221) | 0.69 | 0.195 (0.182–0.209) | 0.19 | 0.206 (0.164–0.259) | 0.07 | |||||
| CT | 0.153 (0.144–0.163) | 0.212 (0.198–0.227) | 0.187 (0.175–0.200) | 0.196 (0.156–0.248) | |||||||||
| TT | 0.158 (0.144–0.172) | 0.214 (0.193–0.236) | 0.179 (0.164–0.196) | 0.167 (0.129–0.217) | |||||||||
| Ins Index | CC | 1.18 (1.06–1.30) | 0.31 | 1.14 (1.02–1.25) | 0.32 | 1.15 (1.04–1.26) | 0.26 | 1.08 (0.93–1.24) | 0.96 | ||||
| CT | 1.28 (1.17–1.39) | 1.19 (1.09–1.30) | 1.15 (1.05–1.26) | 1.08 (0.94–1.23) | |||||||||
| TT | 1.23 (1.08–1.39) | 1.08 (0.93–1.23) | 1.03 (0.90–1.17) | 1.11 (0.91–1.33) | |||||||||
| rs11037909, EXT2 ISI | TT | 0.150 (0.140–0.161) | 0.46 | 0.213 (0.198–0.230) | 0.58 | 0.190 (0.178–0.204) | 0.05 | 0.185 (0.146–0.234) | 0.33 | ||||
| CT | 0.157 (0.147–0.168) | 0.205 (0.191–0.220) | 0.195 (0.182–0.209) | 0.188 (0.147–0.239) | |||||||||
| CC | 0.157 (0.142–0.172) | 0.213 (0.191–0.238) | 0.169 (0.152–0.188) | 0.220 (0.167–0.289) | |||||||||
| Ins Index | TT | 1.25 (1.13–1.37) | 0.74 | 1.09 (0.98–1.20) | 0.18 | 1.13 (1.03–1.24) | 0.86 | 1.07 (0.93–1.21) | 0.31 | ||||
| CT | 1.21 (1.09–1.33) | 1.20 (1.09–1.31) | 1.11 (1.00–1.21) | 1.05 (0.90–1.20) | |||||||||
| CC | 1.26 (1.10–1.43) | 1.18 (1.01–1.35) | 1.14 (0.98–1.31) | 1.29 (1.00–1.60) | |||||||||
| rs1113132, EXT2 ISI | CC | 0.159 (0.145–0.175) | 0.18 | 0.219 (0.198–0.242) | 0.57 | 0.194 (0.176–0.214) | 0.51 | 0.209 (0.163–0.267) | 0.31 | ||||
| CG | 0.149 (0.140–0.159) | 0.207 (0.194–0.222) | 0.190 (0.178–0.203) | 0.184 (0.146–0.232) | |||||||||
| GG | 0.158 (0.148–0.169) | 0.211 (0.196–0.227) | 0.184 (0.172–0.197) | 0.196 (0.154–0.248) | |||||||||
| Ins Index | CC | 1.29 (1.13–1.46) | 0.70 | 1.05 (0.90–1.21) | 0.11 | 1.09 (0.95–1.24) | 0.67 | 1.15 (0.94–1.38) | 0.77 | ||||
| CG | 1.22 (1.11–1.33) | 1.13 (1.03–1.23) | 1.11 (1.01–1.21) | 1.07 (0.93–1.21) | |||||||||
| GG | 1.23 (1.11–1.35) | 1.22 (1.11–1.34) | 1.15 (1.04–1.25) | 1.08 (0.92–1.23) | |||||||||
| rs3740878, EXT2 ISI | TT | 0.151 (0.141–0.162) | 0.44 | 0.214 (0.199–0.230) | 0.54 | 0.190 (0.177–0.203) | 0.15 | 0.184 (0.145–0.233) | 0.32 | ||||
| CT | 0.158 (0.148–0.169) | 0.205 (0.190–0.220) | 0.194 (0.181–0.208) | 0.189 (0.148–0.240) | |||||||||
| CC | 0.154 (0.140–0.170) | 0.211 (0.189–0.237) | 0.172 (0.154–0.192) | 0.220 (0.167–0.289) | |||||||||
| Ins Index | TT | 1.27 (1.15–1.40) | 0.65 | 1.09 (0.98–1.20) | 0.17 | 1.15 (1.05–1.26) | 0.30 | 1.09 (0.96–1.23) | 0.21 | ||||
| CT | 1.22 (1.10–1.34) | 1.20 (1.08–1.31) | 1.08 (0.97–1.18) | 1.02 (0.87–1.17) | |||||||||
| CC | 1.20 (1.04–1.37) | 1.20 (1.03–1.38) | 1.17 (1.00–1.34) | 1.29 (1.00–1.60) | |||||||||
| rs13266634, SLC30A8 ISI | |||||||||||||
| CC | 0.155 (0.146–0.164) | 0.54 | 0.206 (0.193–0.220) | 0.45 | 0.188 (0.176–0.200) | 0.91 | 0.208 (0.165–0.262) | 0.19 | |||||
| CT | 0.152 (0.142–0.163) | 0.214 (0.199–0.230) | 0.189 (0.176–0.203) | 0.186 (0.147–0.234) | |||||||||
| TT | 0.165 (0.143–0.190) | 0.222 (0.194–0.255) | 0.184 (0.160–0.212) | 0.185 (0.136–0.250) | |||||||||
| Ins Index | CC | 1.26 (1.16–1.36) | 0.36 | 1.11 (1.01–1.21) | 0.22 | 1.10 (1.01–1.20) | 0.16 | 1.09 (0.96–1.22) | 0.90 | ||||
| CT | 1.21 (1.10–1.34) | 1.21 (1.10–1.33) | 1.13 (1.02–1.24) | 1.07 (0.91–1.23) | |||||||||
| TT | 1.09 (0.85–1.34) | 1.11 (0.91–1.32) | 1.30 (1.09–1.53) | 1.14 (0.85–1.46) | |||||||||
| rs7480010, LOC387761 ISI | |||||||||||||
| GG | 0.157 (0.142–0.173) | 0.59 | 0.204 (0.183–0.227) | 0.83 | 0.176 (0.161–0.194) | 0.21 | 0.188 (0.144–0.246) | 0.89 | |||||
| GA | 0.157 (0.147–0.168) | 0.211 (0.195–0.227) | 0.193 (0.179–0.207) | 0.197 (0.155–0.250) | |||||||||
| AA | 0.152 (0.142–0.162) | 0.212 (0.198–0.227) | 0.190 (0.177–0.204) | 0.197 (0.156–0.248) | |||||||||
| Ins Index | GG | 1.34 (1.17–1.52) | 0.26 | 1.17 (1.00–1.34) | 0.98 | 1.15 (1.01–1.30) | 0.89 | 1.11 (0.89–1.34) | 0.79 | ||||
| GA | 1.24 (1.12–1.37) | 1.15 (1.03–1.27) | 1.12 (1.01–1.23) | 1.05 (0.90–1.21) | |||||||||
| AA | 1.18 (1.07–1.30) | 1.15 (1.05–1.26) | 1.11 (1.01–1.22) | 1.10 (0.95–1.26) | |||||||||
| rs10811661, CDKN2A/B ISI | |||||||||||||
| TT | 0.154 (0.146–0.163) | 0.68 | 0.207 (0.195–0.220) | 0.13 | 0.190 (0.179–0.202) | 0.15 | 0.197 (0.156–0.247) | 0.96 | |||||
| CT | 0.152 (0.140–0.165) | 0.215 (0.198–0.234) | 0.189 (0.174–0.205) | 0.193 (0.152–0.245) | |||||||||
| CC | 0.167 (0.135–0.205) | 0.257 (0.206–0.320) | 0.153 (0.123–0.190) | 0.199 (0.134–0.294) | |||||||||
| Ins Index | TT | 1.23 (1.13–1.33) | 0.46 | 1.18 (1.09–1.28) | 0.05 | 1.46 (1.12–1.83) | 0.12 | 1.01 (0.88–1.13) | 0.01 | ||||
| CT | 1.29 (1.14–1.43) | 1.04 (0.92–1.17) | 1.09 (0.97–1.21) | 1.12 (0.94–1.31) | |||||||||
| CC | 1.06 (0.72–1.44) | 1.30 (0.96–1.67) | 1.12 (1.02–1.21) | 1.71 (1.24–2.22) | |||||||||
| rs1470579, IGF2BP2 | |||||||||||||
| ISI | CC | 0.161 (0.147–0.177) | 0.52 | 0.225 (0.204–0.247) | 0.02 | 0.198 (0.181–0.216) | 0.32 | 0.191 (0.147–0.248) | 0.31 | ||||
| AC | 0.152 (0.142–0.163) | 0.217 (0.202–0.234) | 0.187 (0.175–0.200) | 0.185 (0.146–0.234) | |||||||||
| AA | 0.154 (0.144–0.164) | 0.197 (0.184–0.212) | 0.184 (0.172–0.198) | 0.205 (0.162–0.258) | |||||||||
| Ins Index | CC | 1.17 (1.01–1.34) | 0.55 | 1.07 (0.93–1.21) | 0.03 | 1.12 (1.02–1.23) | 0.84 | 1.20 (1.00–1.42) | 0.17 | ||||
| AC | 1.26 (1.15–1.39) | 1.10 (0.99–1.21) | 1.11 (1.01–1.21) | 0.99 (0.84–1.14) | |||||||||
| AA | 1.23 (1.12–1.35) | 1.25 (1.14–1.37) | 1.15 (1.02–1.29) | 1.09 (0.93–1.25) | |||||||||
| rs7754840, | |||||||||||||
| CDKAL1 ISI | CC | 0.159 (0.145–0.175) | 0.18 | 0.219 (0.198–0.242) | 0.57 | 0.194 (0.176–0.214) | 0.51 | 0.209 (0.163–0.267) | 0.31 | ||||
| CG | 0.149 (0.140–0.159) | 0.207 (0.194–0.222) | 0.190 (0.178–0.203) | 0.184 (0.146–0.232) | |||||||||
| GG | 0.158 (0.148–0.169) | 0.211 (0.196–0.227) | 0.184 (0.172–0.197) | 0.196 (0.154–0.248) | |||||||||
| Ins Index | CC | 1.29 (1.13–1.46) | 0.70 | 1.05 (0.90–1.21) | 0.11 | 1.09 (0.95–1.24) | 0.67 | 1.15 (0.94–1.38) | 0.77 | ||||
| CG | 1.22 (1.11–1.33) | 1.13 (1.03–1.23) | 1.11 (1.01–1.21) | 1.07 (0.93–1.21) | |||||||||
| GG | 1.23 (1.11–1.35) | 1.22 (1.11–1.34) | 1.15 (1.04–1.25) | 1.08 (0.92–1.23) | |||||||||
Data are least squares means(95% CI) and are also adjusted for the baseline values. Risk allele listed first. ISI is expressed as [(μU/ml) × (mmol/l)]−1; Ins Index, insulinogenic index expressed as [(μU/ml)/(mg/dl)].