Echocardiographic evaluation of contractile function in wild-type and Akita mice at 20, 36, and 54 weeks of age
| . | n . | Fractional shortening (%) . | Ejection fraction (%) . | Heart rate (bpm) . | Stroke volume (μl/g body wt) . | Cardiac output (μl · min−1 · g−1 body wt) . |
|---|---|---|---|---|---|---|
| Wild type (20 weeks) | 9 | 38.6 ± 2.4 | 76 ± 3 | 415 ± 12 | 1.13 ± 0.03 | 467 ± 14 |
| Akita (20 weeks) | 7 | 38.7 ± 2.4 | 76 ± 3 | 472 ± 31 | 1.12 ± 0.07 | 527 ± 15* |
| Wild type (36 weeks) | 6 | 39.6 ± 1.2 | 78 ± 1 | 470 ± 41 | 0.97 ± 0.04 | 456 ± 25 |
| Akita (36 weeks) | 5 | 39.7 ± 2.7 | 78 ± 3 | 421 ± 29 | 1.13 ± 0.04* | 476 ± 33 |
| Wild type (54 weeks) | 6 | 24.6 ± 1.9 | 57 ± 3 | 523 ± 29 | 1.00 ± 0.10 | 524 ± 28 |
| Akita (54 weeks) | 6 | 27.6 ± 1.9 | 62 ± 3 | 448 ± 28 | 0.95 ± 0.04 | 426 ± 28* |
| . | n . | Fractional shortening (%) . | Ejection fraction (%) . | Heart rate (bpm) . | Stroke volume (μl/g body wt) . | Cardiac output (μl · min−1 · g−1 body wt) . |
|---|---|---|---|---|---|---|
| Wild type (20 weeks) | 9 | 38.6 ± 2.4 | 76 ± 3 | 415 ± 12 | 1.13 ± 0.03 | 467 ± 14 |
| Akita (20 weeks) | 7 | 38.7 ± 2.4 | 76 ± 3 | 472 ± 31 | 1.12 ± 0.07 | 527 ± 15* |
| Wild type (36 weeks) | 6 | 39.6 ± 1.2 | 78 ± 1 | 470 ± 41 | 0.97 ± 0.04 | 456 ± 25 |
| Akita (36 weeks) | 5 | 39.7 ± 2.7 | 78 ± 3 | 421 ± 29 | 1.13 ± 0.04* | 476 ± 33 |
| Wild type (54 weeks) | 6 | 24.6 ± 1.9 | 57 ± 3 | 523 ± 29 | 1.00 ± 0.10 | 524 ± 28 |
| Akita (54 weeks) | 6 | 27.6 ± 1.9 | 62 ± 3 | 448 ± 28 | 0.95 ± 0.04 | 426 ± 28* |
Data are means ± SE unless otherwise indicated.
P < 0.05 vs. wild type.