American Diabetes Association

TABLE 1

Change in body weight and blood glucose

	Week
	0	4	18	26	29
Body weight (g)
Control diet
Wild type	26.5 ± 0.7	30.6 ± 1.0	34.9 ± 1.8	37.8 ± 1.7	37.9 ± 1.4
α2i TG	25.0 ± 0.6	29.4 ± 0.6	32.7 ± 1.2	35.5 ± 1.3	36.4 ± 1.2
High-fat diet
Wild type	24.8 ± 0.7	34.1 ± 0.8^*	41.3 ± 1.9^*	47.3 ± 2.5^*	47.6 ± 2.5^*
α2i TG	24.9 ± 0.5	34.9 ± 0.8^*	42.7 ± 1.7^*	49.2 ± 1.0^*	48.6 ± 1.5^*
Blood glucose (mg/dl)
Control diet
Wild type	190.6 ± 10.8	127.8 ± 5.1	136.4 ± 6.9	130.8 ± 6.9	126.6 ± 20.3
α2i TG	165.4 ± 11.4	155.0 ± 11.1	133.6 ± 12.7	122.4 ± 9.3	143.5 ± 29.4
High-fat diet
Wild type	171.8 ± 16.6	165.0 ± 12.8	149.0 ± 28.6	154.5 ± 7.9	162.0 ± 17.6^*
α2i TG	182.5 ± 12.3	160.3 ± 10.8	157.2 ± 6.4	150.3 ± 14.3^‡	191.5 ± 18.3^‡

	Week
	0	4	18	26	29
Body weight (g)
Control diet
Wild type	26.5 ± 0.7	30.6 ± 1.0	34.9 ± 1.8	37.8 ± 1.7	37.9 ± 1.4
α2i TG	25.0 ± 0.6	29.4 ± 0.6	32.7 ± 1.2	35.5 ± 1.3	36.4 ± 1.2
High-fat diet
Wild type	24.8 ± 0.7	34.1 ± 0.8^*	41.3 ± 1.9^*	47.3 ± 2.5^*	47.6 ± 2.5^*
α2i TG	24.9 ± 0.5	34.9 ± 0.8^*	42.7 ± 1.7^*	49.2 ± 1.0^*	48.6 ± 1.5^*
Blood glucose (mg/dl)
Control diet
Wild type	190.6 ± 10.8	127.8 ± 5.1	136.4 ± 6.9	130.8 ± 6.9	126.6 ± 20.3
α2i TG	165.4 ± 11.4	155.0 ± 11.1	133.6 ± 12.7	122.4 ± 9.3	143.5 ± 29.4
High-fat diet
Wild type	171.8 ± 16.6	165.0 ± 12.8	149.0 ± 28.6	154.5 ± 7.9	162.0 ± 17.6^*
α2i TG	182.5 ± 12.3	160.3 ± 10.8	157.2 ± 6.4	150.3 ± 14.3^‡	191.5 ± 18.3^‡

Data are means ± SE. n = 5–6 for all points.

*

P < 0.01 vs. control diet in same genotype.

‡

P < 0.05 vs. control diet in same genotype.