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TABLE 3

Univariate correlations between progranulin mRNA expression in visceral and subcutaneous adipose tissue and measures of obesity, insulin sensitivity, and parameters of inflammation (n = 55)

rP valueAdjusted for BMI
rP value
Visceral progranulin mRNA     
    Serum progranulin 0.27 <0.01 0.17 0.03 
    CRP 0.25 <0.01 0.18 0.02 
    MCP-1 0.18 0.03 0.06 0.6 
    Visceral fat area 0.46 <0.001 0.28 <0.01 
    BMI 0.41 <0.01 — — 
    Body fat (%) 0.39 <0.01 0.04 0.7 
    Visceral macrophage number 0.62 <0.001 0.45 <0.001 
    HDL cholesterol −0.35 <0.001 −0.12 0.1 
    GIR −0.31 <0.01 −0.11 0.1 
Subcutaneous progranulin mRNA     
    Subcutaneous macrophage number 0.6 <0.001 0.38 <0.001 
    CRP 0.34 <0.001 0.22 0.01 
rP valueAdjusted for BMI
rP value
Visceral progranulin mRNA     
    Serum progranulin 0.27 <0.01 0.17 0.03 
    CRP 0.25 <0.01 0.18 0.02 
    MCP-1 0.18 0.03 0.06 0.6 
    Visceral fat area 0.46 <0.001 0.28 <0.01 
    BMI 0.41 <0.01 — — 
    Body fat (%) 0.39 <0.01 0.04 0.7 
    Visceral macrophage number 0.62 <0.001 0.45 <0.001 
    HDL cholesterol −0.35 <0.001 −0.12 0.1 
    GIR −0.31 <0.01 −0.11 0.1 
Subcutaneous progranulin mRNA     
    Subcutaneous macrophage number 0.6 <0.001 0.38 <0.001 
    CRP 0.34 <0.001 0.22 0.01 

GIR, glucose infusion rate during the steady state of a euglycemic-hyperinsulinemic clamp.

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