Hepatic glucose storage and utilization
| Parameter . | Con . | STZ-Con . | STZ-Tg . |
|---|---|---|---|
| GK (mU/mg protein) | 22 ± 3 | 8 ± 1 | 19 ± 2* |
| Glucose-6-P (nmol/g liver) | 248 ± 11 | 103 ± 9 | 218 ± 12* |
| Glycogen (mg/g liver) | 43 ± 4 | 11 ± 4 | 35 ± 3* |
| Parameter . | Con . | STZ-Con . | STZ-Tg . |
|---|---|---|---|
| GK (mU/mg protein) | 22 ± 3 | 8 ± 1 | 19 ± 2* |
| Glucose-6-P (nmol/g liver) | 248 ± 11 | 103 ± 9 | 218 ± 12* |
| Glycogen (mg/g liver) | 43 ± 4 | 11 ± 4 | 35 ± 3* |
Data are the means ± SE of 10 mice in each group. GK activity and glucose 6-phosphate (Glucose-6-P) and glycogen concentrations were measured in liver extracts of healthy control (Con), STZ-treated control (STZ-Con), and Tg1 transgenic (STZ-Tg) mice as described in research design and methods.
P < 0.05 vs. Stz-Con.