Association between baseline lipid scores and T2D risk
| . | Quartiles of scores . | Linear trend . | Per SD . | |||
|---|---|---|---|---|---|---|
| Q1 . | Q2 . | Q3 . | Q4 . | |||
| LP score (LPCs and LPEs); n molecules = 18 | ||||||
| M1* | Ref | 0.82 (0.56–1.19) | 0.49 (0.32–0.75) | 0.46 (0.29–0.71) | <0.001 | 0.73 (0.63–0.85) |
| M2* | Ref | 0.86 (0.58–1.27) | 0.48 (0.31–0.76) | 0.51 (0.32–0.81) | <0.001 | 0.74 (0.63–0.87) |
| M3* | Ref | 1.09 (0.69–1.73) | 0.54 (0.30–0.97) | 0.66 (0.38–1.16) | 0.040 | 0.79 (0.65–0.96) |
| PC-PL score; n molecules = 15 | ||||||
| M1* | Ref | 0.78 (0.53–1.17) | 0.77 (0.52–1.16) | 0.36 (0.22–0.58) | <0.001 | 0.78 (0.68–0.90) |
| M2* | Ref | 0.80 (0.53–1.21) | 0.81 (0.54–1.22) | 0.38 (0.23–0.64) | 0.001 | 0.82 (0.71–0.95) |
| M3* | Ref | 0.81 (0.49–1.33) | 0.66 (0.39–1.09) | 0.37 (0.20–0.68) | 0.001 | 0.76 (0.62–0.92) |
| SM score; n molecules = 11 | ||||||
| M1* | Ref | 0.49 (0.32–0.75) | 0.58 (0.38–0.89) | 0.32 (0.19–0.54) | <0.001 | 0.67 (0.56–0.80) |
| M2* | Ref | 0.46 (0.30–0.72) | 0.56 (0.35–0.87) | 0.31 (0.18–0.52) | <0.001 | 0.69 (0.57–0.83) |
| M3* | Ref | 0.30 (0.17–0.52) | 0.51 (0.30–0.88) | 0.24 (0.13–0.45) | <0.001 | 0.67 (0.54–0.84) |
| CE score; n molecules = 13 | ||||||
| M1* | Ref | 0.76 (0.50–1.14) | 0.64 (0.43–0.95) | 0.34 (0.21–0.54) | <0.001 | 0.68 (0.58–0.79) |
| M2* | Ref | 0.87 (0.56–1.35) | 0.74 (0.49–1.12) | 0.39 (0.24–0.65) | <0.001 | 0.70 (0.59–0.84) |
| M3* | Ref | 0.64 (0.36–1.15) | 0.56 (0.34–0.91) | 0.40 (0.22–0.74) | 0.002 | 0.68 (0.56–0.83) |
| TAG score (≤56 C and ≤3 double bonds); n molecules = 40 | ||||||
| M1* | Ref | 1.73 (1.06–2.83) | 2.18 (1.35–3.51) | 2.94 (1.85–4.67) | <0.001 | 1.49 (1.27–1.75) |
| M2* | Ref | 1.77 (1.06–2.94) | 2.10 (1.28–3.43) | 2.55 (1.58–4.11) | <0.001 | 1.39 (1.18–1.64) |
| M3* | Ref | 1.60 (0.82–3.14) | 2.01 (1.04–3.86) | 2.02 (1.05–3.87) | 0.044 | 1.23 (1.00–1.52) |
| DAG score; n molecules = 14 | ||||||
| M1* | Ref | 1.14 (0.70–1.86) | 2.13 (1.35–3.36) | 2.76 (1.77–4.29) | <0.001 | 1.58 (1.33–1.86) |
| M2* | Ref | 1.25 (0.75–2.08) | 1.95 (1.21–3.14) | 2.46 (1.56–3.88) | <0.001 | 1.48 (1.24–1.77) |
| M3* | Ref | 1.18 (0.61–2.30) | 1.52 (0.84–2.74) | 1.93 (1.10–3.37) | 0.008 | 1.31 (1.07–1.61) |
| PE score; n molecules = 12 | ||||||
| M1* | Ref | 1.51 (0.95–2.39) | 1.57 (0.95–2.39) | 2.55 (1.64–3.95) | <0.001 | 1.45 (1.23–1.70) |
| M2* | Ref | 1.43 (0.89–2.31) | 1.48 (0.92–2.38) | 2.13 (1.35–3.35) | 0.001 | 1.35 (1.15–1.59) |
| M3* | Ref | 1.30 (0.74–2.78) | 0.95 (0.52–2.42) | 1.39 (0.80–2.42) | 0.321 | 1.13 (0.93–1.37) |
| . | Quartiles of scores . | Linear trend . | Per SD . | |||
|---|---|---|---|---|---|---|
| Q1 . | Q2 . | Q3 . | Q4 . | |||
| LP score (LPCs and LPEs); n molecules = 18 | ||||||
| M1* | Ref | 0.82 (0.56–1.19) | 0.49 (0.32–0.75) | 0.46 (0.29–0.71) | <0.001 | 0.73 (0.63–0.85) |
| M2* | Ref | 0.86 (0.58–1.27) | 0.48 (0.31–0.76) | 0.51 (0.32–0.81) | <0.001 | 0.74 (0.63–0.87) |
| M3* | Ref | 1.09 (0.69–1.73) | 0.54 (0.30–0.97) | 0.66 (0.38–1.16) | 0.040 | 0.79 (0.65–0.96) |
| PC-PL score; n molecules = 15 | ||||||
| M1* | Ref | 0.78 (0.53–1.17) | 0.77 (0.52–1.16) | 0.36 (0.22–0.58) | <0.001 | 0.78 (0.68–0.90) |
| M2* | Ref | 0.80 (0.53–1.21) | 0.81 (0.54–1.22) | 0.38 (0.23–0.64) | 0.001 | 0.82 (0.71–0.95) |
| M3* | Ref | 0.81 (0.49–1.33) | 0.66 (0.39–1.09) | 0.37 (0.20–0.68) | 0.001 | 0.76 (0.62–0.92) |
| SM score; n molecules = 11 | ||||||
| M1* | Ref | 0.49 (0.32–0.75) | 0.58 (0.38–0.89) | 0.32 (0.19–0.54) | <0.001 | 0.67 (0.56–0.80) |
| M2* | Ref | 0.46 (0.30–0.72) | 0.56 (0.35–0.87) | 0.31 (0.18–0.52) | <0.001 | 0.69 (0.57–0.83) |
| M3* | Ref | 0.30 (0.17–0.52) | 0.51 (0.30–0.88) | 0.24 (0.13–0.45) | <0.001 | 0.67 (0.54–0.84) |
| CE score; n molecules = 13 | ||||||
| M1* | Ref | 0.76 (0.50–1.14) | 0.64 (0.43–0.95) | 0.34 (0.21–0.54) | <0.001 | 0.68 (0.58–0.79) |
| M2* | Ref | 0.87 (0.56–1.35) | 0.74 (0.49–1.12) | 0.39 (0.24–0.65) | <0.001 | 0.70 (0.59–0.84) |
| M3* | Ref | 0.64 (0.36–1.15) | 0.56 (0.34–0.91) | 0.40 (0.22–0.74) | 0.002 | 0.68 (0.56–0.83) |
| TAG score (≤56 C and ≤3 double bonds); n molecules = 40 | ||||||
| M1* | Ref | 1.73 (1.06–2.83) | 2.18 (1.35–3.51) | 2.94 (1.85–4.67) | <0.001 | 1.49 (1.27–1.75) |
| M2* | Ref | 1.77 (1.06–2.94) | 2.10 (1.28–3.43) | 2.55 (1.58–4.11) | <0.001 | 1.39 (1.18–1.64) |
| M3* | Ref | 1.60 (0.82–3.14) | 2.01 (1.04–3.86) | 2.02 (1.05–3.87) | 0.044 | 1.23 (1.00–1.52) |
| DAG score; n molecules = 14 | ||||||
| M1* | Ref | 1.14 (0.70–1.86) | 2.13 (1.35–3.36) | 2.76 (1.77–4.29) | <0.001 | 1.58 (1.33–1.86) |
| M2* | Ref | 1.25 (0.75–2.08) | 1.95 (1.21–3.14) | 2.46 (1.56–3.88) | <0.001 | 1.48 (1.24–1.77) |
| M3* | Ref | 1.18 (0.61–2.30) | 1.52 (0.84–2.74) | 1.93 (1.10–3.37) | 0.008 | 1.31 (1.07–1.61) |
| PE score; n molecules = 12 | ||||||
| M1* | Ref | 1.51 (0.95–2.39) | 1.57 (0.95–2.39) | 2.55 (1.64–3.95) | <0.001 | 1.45 (1.23–1.70) |
| M2* | Ref | 1.43 (0.89–2.31) | 1.48 (0.92–2.38) | 2.13 (1.35–3.35) | 0.001 | 1.35 (1.15–1.59) |
| M3* | Ref | 1.30 (0.74–2.78) | 0.95 (0.52–2.42) | 1.39 (0.80–2.42) | 0.321 | 1.13 (0.93–1.37) |
Data are HR (95% CI) unless otherwise indicated. Boldface type indicates P values <0.05 for the association with T2D (HR).
*M1: adjusted for age, sex, and intervention group; M2: M1 additionally adjusted for BMI, smoking, hypertension, and dyslipidemia; M3: M2 additionally adjusted for baseline glucose (linear and quadratic term). Ref, reference; Q, quartile.