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Table 3

Association between baseline lipid scores and T2D risk

Quartiles of scores
Linear trendPer SD
Q1Q2Q3Q4
LP score (LPCs and LPEs); n molecules = 18 
 M1* Ref 0.82 (0.56–1.19) 0.49 (0.32–0.75) 0.46 (0.29–0.71) <0.001 0.73 (0.63–0.85) 
 M2* Ref 0.86 (0.58–1.27) 0.48 (0.31–0.76) 0.51 (0.32–0.81) <0.001 0.74 (0.63–0.87) 
 M3* Ref 1.09 (0.69–1.73) 0.54 (0.30–0.97) 0.66 (0.38–1.16) 0.040 0.79 (0.65–0.96) 
PC-PL score; n molecules = 15 
 M1* Ref 0.78 (0.53–1.17) 0.77 (0.52–1.16) 0.36 (0.22–0.58) <0.001 0.78 (0.68–0.90) 
 M2* Ref 0.80 (0.53–1.21) 0.81 (0.54–1.22) 0.38 (0.23–0.64) 0.001 0.82 (0.71–0.95) 
 M3* Ref 0.81 (0.49–1.33) 0.66 (0.39–1.09) 0.37 (0.20–0.68) 0.001 0.76 (0.62–0.92) 
SM score; n molecules = 11 
 M1* Ref 0.49 (0.32–0.75) 0.58 (0.38–0.89) 0.32 (0.19–0.54) <0.001 0.67 (0.56–0.80) 
 M2* Ref 0.46 (0.30–0.72) 0.56 (0.35–0.87) 0.31 (0.18–0.52) <0.001 0.69 (0.57–0.83) 
 M3* Ref 0.30 (0.17–0.52) 0.51 (0.30–0.88) 0.24 (0.13–0.45) <0.001 0.67 (0.54–0.84) 
CE score; n molecules = 13 
 M1* Ref 0.76 (0.50–1.14) 0.64 (0.43–0.95) 0.34 (0.21–0.54) <0.001 0.68 (0.58–0.79) 
 M2* Ref 0.87 (0.56–1.35) 0.74 (0.49–1.12) 0.39 (0.24–0.65) <0.001 0.70 (0.59–0.84) 
 M3* Ref 0.64 (0.36–1.15) 0.56 (0.34–0.91) 0.40 (0.22–0.74) 0.002 0.68 (0.56–0.83) 
TAG score (≤56 C and ≤3 double bonds); n molecules = 40 
 M1* Ref 1.73 (1.06–2.83) 2.18 (1.35–3.51) 2.94 (1.85–4.67) <0.001 1.49 (1.27–1.75) 
 M2* Ref 1.77 (1.06–2.94) 2.10 (1.28–3.43) 2.55 (1.58–4.11) <0.001 1.39 (1.18–1.64) 
 M3* Ref 1.60 (0.82–3.14) 2.01 (1.04–3.86) 2.02 (1.05–3.87) 0.044 1.23 (1.00–1.52) 
DAG score; n molecules = 14 
 M1* Ref 1.14 (0.70–1.86) 2.13 (1.35–3.36) 2.76 (1.77–4.29) <0.001 1.58 (1.33–1.86) 
 M2* Ref 1.25 (0.75–2.08) 1.95 (1.21–3.14) 2.46 (1.56–3.88) <0.001 1.48 (1.24–1.77) 
 M3* Ref 1.18 (0.61–2.30) 1.52 (0.84–2.74) 1.93 (1.10–3.37) 0.008 1.31 (1.07–1.61) 
PE score; n molecules = 12 
 M1* Ref 1.51 (0.95–2.39) 1.57 (0.95–2.39) 2.55 (1.64–3.95) <0.001 1.45 (1.23–1.70) 
 M2* Ref 1.43 (0.89–2.31) 1.48 (0.92–2.38) 2.13 (1.35–3.35) 0.001 1.35 (1.15–1.59) 
 M3* Ref 1.30 (0.74–2.78) 0.95 (0.52–2.42) 1.39 (0.80–2.42) 0.321 1.13 (0.93–1.37) 
Quartiles of scores
Linear trendPer SD
Q1Q2Q3Q4
LP score (LPCs and LPEs); n molecules = 18 
 M1* Ref 0.82 (0.56–1.19) 0.49 (0.32–0.75) 0.46 (0.29–0.71) <0.001 0.73 (0.63–0.85) 
 M2* Ref 0.86 (0.58–1.27) 0.48 (0.31–0.76) 0.51 (0.32–0.81) <0.001 0.74 (0.63–0.87) 
 M3* Ref 1.09 (0.69–1.73) 0.54 (0.30–0.97) 0.66 (0.38–1.16) 0.040 0.79 (0.65–0.96) 
PC-PL score; n molecules = 15 
 M1* Ref 0.78 (0.53–1.17) 0.77 (0.52–1.16) 0.36 (0.22–0.58) <0.001 0.78 (0.68–0.90) 
 M2* Ref 0.80 (0.53–1.21) 0.81 (0.54–1.22) 0.38 (0.23–0.64) 0.001 0.82 (0.71–0.95) 
 M3* Ref 0.81 (0.49–1.33) 0.66 (0.39–1.09) 0.37 (0.20–0.68) 0.001 0.76 (0.62–0.92) 
SM score; n molecules = 11 
 M1* Ref 0.49 (0.32–0.75) 0.58 (0.38–0.89) 0.32 (0.19–0.54) <0.001 0.67 (0.56–0.80) 
 M2* Ref 0.46 (0.30–0.72) 0.56 (0.35–0.87) 0.31 (0.18–0.52) <0.001 0.69 (0.57–0.83) 
 M3* Ref 0.30 (0.17–0.52) 0.51 (0.30–0.88) 0.24 (0.13–0.45) <0.001 0.67 (0.54–0.84) 
CE score; n molecules = 13 
 M1* Ref 0.76 (0.50–1.14) 0.64 (0.43–0.95) 0.34 (0.21–0.54) <0.001 0.68 (0.58–0.79) 
 M2* Ref 0.87 (0.56–1.35) 0.74 (0.49–1.12) 0.39 (0.24–0.65) <0.001 0.70 (0.59–0.84) 
 M3* Ref 0.64 (0.36–1.15) 0.56 (0.34–0.91) 0.40 (0.22–0.74) 0.002 0.68 (0.56–0.83) 
TAG score (≤56 C and ≤3 double bonds); n molecules = 40 
 M1* Ref 1.73 (1.06–2.83) 2.18 (1.35–3.51) 2.94 (1.85–4.67) <0.001 1.49 (1.27–1.75) 
 M2* Ref 1.77 (1.06–2.94) 2.10 (1.28–3.43) 2.55 (1.58–4.11) <0.001 1.39 (1.18–1.64) 
 M3* Ref 1.60 (0.82–3.14) 2.01 (1.04–3.86) 2.02 (1.05–3.87) 0.044 1.23 (1.00–1.52) 
DAG score; n molecules = 14 
 M1* Ref 1.14 (0.70–1.86) 2.13 (1.35–3.36) 2.76 (1.77–4.29) <0.001 1.58 (1.33–1.86) 
 M2* Ref 1.25 (0.75–2.08) 1.95 (1.21–3.14) 2.46 (1.56–3.88) <0.001 1.48 (1.24–1.77) 
 M3* Ref 1.18 (0.61–2.30) 1.52 (0.84–2.74) 1.93 (1.10–3.37) 0.008 1.31 (1.07–1.61) 
PE score; n molecules = 12 
 M1* Ref 1.51 (0.95–2.39) 1.57 (0.95–2.39) 2.55 (1.64–3.95) <0.001 1.45 (1.23–1.70) 
 M2* Ref 1.43 (0.89–2.31) 1.48 (0.92–2.38) 2.13 (1.35–3.35) 0.001 1.35 (1.15–1.59) 
 M3* Ref 1.30 (0.74–2.78) 0.95 (0.52–2.42) 1.39 (0.80–2.42) 0.321 1.13 (0.93–1.37) 

Data are HR (95% CI) unless otherwise indicated. Boldface type indicates P values <0.05 for the association with T2D (HR).

*M1: adjusted for age, sex, and intervention group; M2: M1 additionally adjusted for BMI, smoking, hypertension, and dyslipidemia; M3: M2 additionally adjusted for baseline glucose (linear and quadratic term). Ref, reference; Q, quartile.

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