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Table 9.2

Median monthly (30-day) AWP and NADAC of maximum approved daily dose of noninsulin glucose-lowering agents in the U.S.

ClassCompound(s)Dosage strength/product (if applicable)Median AWP (min, max)†Median NADAC (min, max)†Maximum approved daily dose*
Biguanides • Metformin 850 mg (IR) $108 ($6, $109) $3 2,550 mg 
1,000 mg (IR) $87 ($4, $88) $2 2,000 mg 
1,000 mg (ER) $242 ($242, $7,214) $188 ($188, $572) 2,000 mg 
Sulfonylureas (2nd generation) • Glimepiride 4 mg $74 ($71, $198) $4 8 mg 
• Glipizide 10 mg (IR) $75 ($67, $97) $5 40 mg (IR) 
10 mg (XL) $48 $11 20 mg (XL) 
• Glyburide 6 mg (micronized) $52 ($48, $71) $10 12 mg (micronized) 
5 mg $93 ($63, $103) $11 20 mg 
Thiazolidinediones • Pioglitazone 45 mg $348 ($283, $349) $5 45 mg 
• Rosiglitazone 4 mg $407 $330 8 mg 
α-Glucosidase inhibitors • Acarbose 100 mg $106 ($104, $106) $28 300 mg 
• Miglitol 100 mg $241 $311 300 mg 
Meglitinides (glinides) • Nateglinide 120 mg $155 $31 360 mg 
• Repaglinide 2 mg $878 ($162, $897) $38 16 mg 
DPP-4 inhibitors • Alogliptin 25 mg $234 $175 25 mg 
• Saxagliptin 5 mg $530 $424 5 mg 
• Linagliptin 5 mg $555 $444 5 mg 
• Sitagliptin 100 mg $568 $456 100 mg 
SGLT2 inhibitors • Ertugliflozin 15 mg $354 $284 15 mg 
• Dapagliflozin 10 mg $621 $496 10 mg 
• Empagliflozin 25 mg $627 $501 25 mg 
• Canagliflozin 300 mg $622 $499 300 mg 
GLP-1 RAs • Exenatide (extended release) 2 mg powder for suspension or pen $882 $706 2 mg** 
• Exenatide 10 µg pen $752 $720 20 µg 
• Dulaglutide 4.5/0.5 mL pen $957 $766 4.5 mg** 
• Semaglutide 1 mg pen $973 $779 1 mg** 
14 mg (tablet) $927 $738 14 mg 
• Liraglutide 18 mg/3 mL pen $1,161 $930 1.8 mg 
• Lixisenatide 300 µg/3 mL pen $774 N/A 20 µg 
Bile acid sequestrant • Colesevelam 625 mg tabs $710 ($674, $712) $105 3.75 g 
3.75 g suspension $804 $318 3.75 g 
Dopamine-2 agonist • Bromocriptine 0.8 mg $960 $772 4.8 mg 
Amylin mimetic • Pramlintide 120 µg pen $2702 $2,097 120 µg/injection†† 
ClassCompound(s)Dosage strength/product (if applicable)Median AWP (min, max)†Median NADAC (min, max)†Maximum approved daily dose*
Biguanides • Metformin 850 mg (IR) $108 ($6, $109) $3 2,550 mg 
1,000 mg (IR) $87 ($4, $88) $2 2,000 mg 
1,000 mg (ER) $242 ($242, $7,214) $188 ($188, $572) 2,000 mg 
Sulfonylureas (2nd generation) • Glimepiride 4 mg $74 ($71, $198) $4 8 mg 
• Glipizide 10 mg (IR) $75 ($67, $97) $5 40 mg (IR) 
10 mg (XL) $48 $11 20 mg (XL) 
• Glyburide 6 mg (micronized) $52 ($48, $71) $10 12 mg (micronized) 
5 mg $93 ($63, $103) $11 20 mg 
Thiazolidinediones • Pioglitazone 45 mg $348 ($283, $349) $5 45 mg 
• Rosiglitazone 4 mg $407 $330 8 mg 
α-Glucosidase inhibitors • Acarbose 100 mg $106 ($104, $106) $28 300 mg 
• Miglitol 100 mg $241 $311 300 mg 
Meglitinides (glinides) • Nateglinide 120 mg $155 $31 360 mg 
• Repaglinide 2 mg $878 ($162, $897) $38 16 mg 
DPP-4 inhibitors • Alogliptin 25 mg $234 $175 25 mg 
• Saxagliptin 5 mg $530 $424 5 mg 
• Linagliptin 5 mg $555 $444 5 mg 
• Sitagliptin 100 mg $568 $456 100 mg 
SGLT2 inhibitors • Ertugliflozin 15 mg $354 $284 15 mg 
• Dapagliflozin 10 mg $621 $496 10 mg 
• Empagliflozin 25 mg $627 $501 25 mg 
• Canagliflozin 300 mg $622 $499 300 mg 
GLP-1 RAs • Exenatide (extended release) 2 mg powder for suspension or pen $882 $706 2 mg** 
• Exenatide 10 µg pen $752 $720 20 µg 
• Dulaglutide 4.5/0.5 mL pen $957 $766 4.5 mg** 
• Semaglutide 1 mg pen $973 $779 1 mg** 
14 mg (tablet) $927 $738 14 mg 
• Liraglutide 18 mg/3 mL pen $1,161 $930 1.8 mg 
• Lixisenatide 300 µg/3 mL pen $774 N/A 20 µg 
Bile acid sequestrant • Colesevelam 625 mg tabs $710 ($674, $712) $105 3.75 g 
3.75 g suspension $804 $318 3.75 g 
Dopamine-2 agonist • Bromocriptine 0.8 mg $960 $772 4.8 mg 
Amylin mimetic • Pramlintide 120 µg pen $2702 $2,097 120 µg/injection†† 

AWP, average wholesale price; DPP-4, dipeptidyl peptidase 4; ER and XL, extended release; GLP-1 RA, glucagon-like peptide 1 receptor agonist; IR, immediate release; max, maximum; min, minimum; N/A, data not available; NADAC, National Average Drug Acquisition Cost; SGLT2, sodium–glucose cotransporter 2. †Calculated for 30-day supply (AWP [62] or NADAC [63] unit price × number of doses required to provide maximum approved daily dose × 30 days); median AWP or NADAC listed alone when only one product and/or price.

*

Utilized to calculate median AWP and NADAC (min, max); generic prices used, if available commercially.

**

Administered once weekly.

††

AWP and NADAC calculated based on 120 mg three times daily.

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