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TABLE 3

Acute response of analytes to injection of saline or oxyntomodulin in the treatment group

Day 1 (saline)
Day 2 (oxyntomodulin)
Day 29 (oxyntomodulin)
Initial valueChange at 30 minInitial valueChange at 30 minPInitial valueChange at 30 minP
Insulin (pmol/l) 34.5 ± 4.7 −6.1 ± 3.2 27.4 ± 3.6 32.6 ± 7.7 0.0004* 26.7 ± 4.3 40.5 ± 10.1 0.0008* 
Glucose (mmol/l) 4.79 ± 0.09 −0.04 ± 0.06 4.73 ± 0.10 0.07 ± 0.08 0.300 4.88 ± 0.09 0.02 ± 0.07 0.6629 
Ghrelin (pmol/l) 370 ± 65 −5 ± 23 375 ± 74 −42 ± 35 0.3429 405 ± 86 −49 ± 22 0.2327 
Peptide YY (pmol/l) 12.2 ± 2.1 1.1 ± 2.2 15.2 ± 4.4 −3.5 ± 4.1 0.3377 12.1 ± 1.6 −2.6 ± 1.3 0.1637 
Day 1 (saline)
Day 2 (oxyntomodulin)
Day 29 (oxyntomodulin)
Initial valueChange at 30 minInitial valueChange at 30 minPInitial valueChange at 30 minP
Insulin (pmol/l) 34.5 ± 4.7 −6.1 ± 3.2 27.4 ± 3.6 32.6 ± 7.7 0.0004* 26.7 ± 4.3 40.5 ± 10.1 0.0008* 
Glucose (mmol/l) 4.79 ± 0.09 −0.04 ± 0.06 4.73 ± 0.10 0.07 ± 0.08 0.300 4.88 ± 0.09 0.02 ± 0.07 0.6629 
Ghrelin (pmol/l) 370 ± 65 −5 ± 23 375 ± 74 −42 ± 35 0.3429 405 ± 86 −49 ± 22 0.2327 
Peptide YY (pmol/l) 12.2 ± 2.1 1.1 ± 2.2 15.2 ± 4.4 −3.5 ± 4.1 0.3377 12.1 ± 1.6 −2.6 ± 1.3 0.1637 

Data are means ± SE. A paired t test was used to compare the change from baseline 30 min after an injection of oxyntomodulin with the change on day 1 when the treatment group injected saline.

*

Significant difference.

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