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Table 1—

Baseline characteristics of older women (NHS I), younger women (NHS II), and men (HPFS) with a history of hypertension according to thiazide use

Thiazide use
YesNo
Older women (NHS I)   
    n 5,248 22,722 
    Age (years) 62.5 62.1 
    BMI (kg/m228.4 27.5 
    Physical activity (METs) 17.1 18.1 
    Currently smoking 542 (10.3) 2688 (11.8) 
    Family history of diabetes 1,324 (25.2) 5,542 (24.4) 
    Coronary heart disease 657 (12.5) 2,889 (12.7) 
    Current postmenopausal hormone use 2,124 (40.5) 8,483 (37.3) 
    Dietary intake   
        Total energy (kcal/day) 1,746 1,726 
        Alcohol (g/day) 5.1 5.1 
        Total carbohydrates (g/day) 212 213 
        Saturated fat (g/day) 17 17 
        Polyunsaturated fat (g/day) 9.0 9.0 
        Trans fat (g/day) 2.3 2.3 
        Magnesium (mg/day) 329 328 
        Caffeine (mg/day) 210 215 
        Cereal fiber (g/day) 5.7 5.8 
    Glycemic index 52.7 52.8 
Younger women (NHS II)   
    n 740 5,158 
    Age (years) 39.8 37.7 
    BMI (kg/m230.9 29.1 
    Physical activity (METs) 17.9 18.9 
    Currently smoking 103 (13.9) 674 (13.1) 
    Family history of diabetes 228 (30.8) 1,638 (31.8) 
    Coronary heart disease 17 (2.3) 69 (1.3) 
    Currently using   
Oral contraceptive 21 (2.8) 313 (6.1) 
Postmenopausal hormones 110 (14.9) 490 (9.5% 
    Dietary intake   
Total energy (kcal/day) 1,781 1,806 
Alcohol (g/day) 2.6 3.2 
Total carbohydrates (g/day) 219 220 
Saturated fat (g/day) 23 23 
Polyunsaturated fat (g/day) 12 12 
Trans fat (g/day) 3.4 3.4 
        Magnesium (mg/day) 314 313 
        Caffeine (mg/day) 239 255 
        Cereal fiber (g/day) 5.4 5.6 
        Glycemic index 53.8 53.7 
Men (HPFS)   
    n 4,061 6,262 
    Age (years) 60.3 57.0 
    BMI (kg/m226.5 26.4 
    Physical activity (METs) 17.1 18.8 
    Currently smoking 383 (9.4) 600 (9.6) 
    Family history of diabetes 726 (17.9) 1,074 (17.2) 
    Coronary heart disease 416 (10.2) 863 (13.8) 
    Dietary intake   
Total energy (kcal/day) 1,927 1,964 
Alcohol (g/day) 13.7 12.8 
Total carbohydrates (g/day) 231 235 
Saturated fat (g/day) 24 24 
Polyunsaturated fat (g/day) 13 13 
Trans fat (g/day) 2.8 2.8 
Magnesium (mg/day) 353 356 
Caffeine (mg/day) 219 216 
Cereal fiber (g/day) 6.7 6.8 
    Glycemic index 52.9 53.1 
Thiazide use
YesNo
Older women (NHS I)   
    n 5,248 22,722 
    Age (years) 62.5 62.1 
    BMI (kg/m228.4 27.5 
    Physical activity (METs) 17.1 18.1 
    Currently smoking 542 (10.3) 2688 (11.8) 
    Family history of diabetes 1,324 (25.2) 5,542 (24.4) 
    Coronary heart disease 657 (12.5) 2,889 (12.7) 
    Current postmenopausal hormone use 2,124 (40.5) 8,483 (37.3) 
    Dietary intake   
        Total energy (kcal/day) 1,746 1,726 
        Alcohol (g/day) 5.1 5.1 
        Total carbohydrates (g/day) 212 213 
        Saturated fat (g/day) 17 17 
        Polyunsaturated fat (g/day) 9.0 9.0 
        Trans fat (g/day) 2.3 2.3 
        Magnesium (mg/day) 329 328 
        Caffeine (mg/day) 210 215 
        Cereal fiber (g/day) 5.7 5.8 
    Glycemic index 52.7 52.8 
Younger women (NHS II)   
    n 740 5,158 
    Age (years) 39.8 37.7 
    BMI (kg/m230.9 29.1 
    Physical activity (METs) 17.9 18.9 
    Currently smoking 103 (13.9) 674 (13.1) 
    Family history of diabetes 228 (30.8) 1,638 (31.8) 
    Coronary heart disease 17 (2.3) 69 (1.3) 
    Currently using   
Oral contraceptive 21 (2.8) 313 (6.1) 
Postmenopausal hormones 110 (14.9) 490 (9.5% 
    Dietary intake   
Total energy (kcal/day) 1,781 1,806 
Alcohol (g/day) 2.6 3.2 
Total carbohydrates (g/day) 219 220 
Saturated fat (g/day) 23 23 
Polyunsaturated fat (g/day) 12 12 
Trans fat (g/day) 3.4 3.4 
        Magnesium (mg/day) 314 313 
        Caffeine (mg/day) 239 255 
        Cereal fiber (g/day) 5.4 5.6 
        Glycemic index 53.8 53.7 
Men (HPFS)   
    n 4,061 6,262 
    Age (years) 60.3 57.0 
    BMI (kg/m226.5 26.4 
    Physical activity (METs) 17.1 18.8 
    Currently smoking 383 (9.4) 600 (9.6) 
    Family history of diabetes 726 (17.9) 1,074 (17.2) 
    Coronary heart disease 416 (10.2) 863 (13.8) 
    Dietary intake   
Total energy (kcal/day) 1,927 1,964 
Alcohol (g/day) 13.7 12.8 
Total carbohydrates (g/day) 231 235 
Saturated fat (g/day) 24 24 
Polyunsaturated fat (g/day) 13 13 
Trans fat (g/day) 2.8 2.8 
Magnesium (mg/day) 353 356 
Caffeine (mg/day) 219 216 
Cereal fiber (g/day) 6.7 6.8 
    Glycemic index 52.9 53.1 

Data are means or n (%). MET, metabolic equivalent.

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