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Table 3—

Antihypertensive medication use and the age-adjusted and multivariate relative risk of incident, symptomatic type 2 diabetes in hypertensive younger women (NHS II), 1991–2001

MedicationCasesPerson-yearsAge-adjusted RR (95% CI)Multivariate R (95% CI)*
Thiazide diuretics     
    No 184 68,158 1.0 (referent) 1.0 (referent) 
    Yes 77 13,485 1.87 (1.43–2.44) 1.51 (1.15–1.98) 
Other     
    No 93 44,765 1.0 (referent) 1.0 (referent) 
    Yes 168 36,877 1.69 (1.30–2.18) 1.37 (1.05–1.77) 
MedicationCasesPerson-yearsAge-adjusted RR (95% CI)Multivariate R (95% CI)*
Thiazide diuretics     
    No 184 68,158 1.0 (referent) 1.0 (referent) 
    Yes 77 13,485 1.87 (1.43–2.44) 1.51 (1.15–1.98) 
Other     
    No 93 44,765 1.0 (referent) 1.0 (referent) 
    Yes 168 36,877 1.69 (1.30–2.18) 1.37 (1.05–1.77) 
*

Adjusted for age (continuous), BMI (continuous), use of each class of hypertensive medication (yes or no), physical activity (quintiles), smoking (current, past, or never), family history of diabetes, alcohol intake (seven categories), quintiles of dietary intake (glycemic load, calcium, magnesium, saturated fat, polyunsaturated fat, trans fat, and cereal fiber), oral contraceptive use (past, current, or never), and coronary heart disease.

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