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Table 1—

Retrospective study: clinical features at diagnosis

Clinical featuresLADAType 2 diabetesP
n 102 111  
Age (years)    
    Median 46.2 (39.1–54.3)* 60.8 (35.9–67.6) <0.0001 
    30.0–39.9 30 (30)† 5 (5) <0.0001 
    40.0–49.9 34 (34) 14 (16) 0.0022 
    50.0–59.9 25 (25) 29 (32) 0.64 
    60.0–69.9 9 (9) 34 (38) <0.0001 
    70.0–80.0 4 (4) 18 (20) 0.001 
Sex (male/female) 50/52 55/56 0.999 
BMI (kg/m2   
    Median 27.9 (24.6–32.5) 30.8 (27.3–34.6) 0.0034 
    Lean (BMI <25) 31 (32) 11 (13) 0.0004 
    Overweight (BMI 25.1–30.0) 26 (27) 30 (33) 0.65 
    Obese (BMI ≥30) 42 (43) 59 (65) 0.0045 
Symptoms    
    Acute symptoms 66 (67) 25 (28) <0.0001 
    Polyuria and/or polydipsia 60 (61) 23 (26) <0.0001 
    Unintentional weight loss 36 (37) 5 (5) <0.0001 
Personal history autoimmune disease    
    Any autoimmune disease 25 (25) 11 (12) 0.011 
    Autoimmune thyroid disease 19 (10) 6.3 (7) 0.007 
    Rheumatoid arthritis 2.0 (2) 2.7 (3) 0.999 
    Celiac disease 0.9 (1) 0.9 (1) 0.999 
    Other autoimmunity 2.9 (3) 2.7 (3) 0.48 
Family history autoimmune disease    
    Any autoimmune disease 46 (47) 31 (34) 0.024 
    Type 1 diabetes 24 (24) 9.9 (11) 0.0092 
    Autoimmune thyroid disease 20 (20) 9.9 (11) 0.053 
    Rheumatoid arthritis 9.8 (10) 6.3 (7) 0.45 
    Celiac disease 2.9 (3) 4.5 (5) 0.72 
    Other autoimmune disease 1.9 (2) 5.4 (6) 0.28 
Family history type 2 diabetes 57 (58) 55 (61) 0.78 
Clinical featuresLADAType 2 diabetesP
n 102 111  
Age (years)    
    Median 46.2 (39.1–54.3)* 60.8 (35.9–67.6) <0.0001 
    30.0–39.9 30 (30)† 5 (5) <0.0001 
    40.0–49.9 34 (34) 14 (16) 0.0022 
    50.0–59.9 25 (25) 29 (32) 0.64 
    60.0–69.9 9 (9) 34 (38) <0.0001 
    70.0–80.0 4 (4) 18 (20) 0.001 
Sex (male/female) 50/52 55/56 0.999 
BMI (kg/m2   
    Median 27.9 (24.6–32.5) 30.8 (27.3–34.6) 0.0034 
    Lean (BMI <25) 31 (32) 11 (13) 0.0004 
    Overweight (BMI 25.1–30.0) 26 (27) 30 (33) 0.65 
    Obese (BMI ≥30) 42 (43) 59 (65) 0.0045 
Symptoms    
    Acute symptoms 66 (67) 25 (28) <0.0001 
    Polyuria and/or polydipsia 60 (61) 23 (26) <0.0001 
    Unintentional weight loss 36 (37) 5 (5) <0.0001 
Personal history autoimmune disease    
    Any autoimmune disease 25 (25) 11 (12) 0.011 
    Autoimmune thyroid disease 19 (10) 6.3 (7) 0.007 
    Rheumatoid arthritis 2.0 (2) 2.7 (3) 0.999 
    Celiac disease 0.9 (1) 0.9 (1) 0.999 
    Other autoimmunity 2.9 (3) 2.7 (3) 0.48 
Family history autoimmune disease    
    Any autoimmune disease 46 (47) 31 (34) 0.024 
    Type 1 diabetes 24 (24) 9.9 (11) 0.0092 
    Autoimmune thyroid disease 20 (20) 9.9 (11) 0.053 
    Rheumatoid arthritis 9.8 (10) 6.3 (7) 0.45 
    Celiac disease 2.9 (3) 4.5 (5) 0.72 
    Other autoimmune disease 1.9 (2) 5.4 (6) 0.28 
Family history type 2 diabetes 57 (58) 55 (61) 0.78 

Data are median (25th–75th percentile) (range) or n (%).

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