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Table 1—

Demographic and clinical characteristics of the study participants at baseline ITT population

Placebo + lifestyleOrlistat + lifestyle
n 1,637 1,640 
Sex (n [%])   
 Female 905 (55.3) 905 (55.2) 
 Male 732 (44.7) 735 (44.8) 
Age (years) 43.7 ± 8.0 43.0 ± 8.0 
Weight (kg) 110.6 ± 16.5 110.4 ± 16.3 
BMI (kg/m237.4 ± 4.5 37.3 ± 4.2 
Waist circumference (cm) 115.4 ± 10.4 115.0 ± 10.4 
IGT patients (n [%]) 344 (21) 350 (21.3) 
Whole blood glucose   
 Fasting (mmol/l) 4.6 ± 0.6 4.6 ± 0.6 
 2 h (mmol/l) 5.5 ± 1.6 5.5 ± 1.6 
 AUC (mmol · min−1 · l−1799 ± 179 804 ± 175 
Serum insulin   
 Fasting (pmol/l) 83.6 ± 47.2 86.1 ± 50.1 
 2 h (pmol/l) 344.9 ± 298.5 370.9 ± 336.7 
 AUC (nmol · min−1 · l−147.7 ± 28.4 49.7 ± 31.3 
Diastolic BP (mmHg) 82.3 ± 10.0 82.0 ± 10.0 
Systolic BP (mmHg) 130.4 ± 15.4 130.8 ± 15.8 
Total cholesterol (mmol/l) 5.8 ± 1.0 5.8 ± 1.0 
LDL cholesterol (mmol/l) 3.8 ± 0.9 3.7 ± 0.9 
HDL cholesterol (mmol/l) 1.2 ± 0.3 1.2 ± 0.3 
LDL-to-HDL ratio 3.3 ± 1.0 3.2 ± 1.1 
Triglycerides (mmol/l) 1.9 ± 1.2 1.9 ± 1.0 
Fibrinogen (μmol/l) 11.7 ± 2.0 11.7 ± 2.2 
Plasminogen activator inhibitor-1 (U/ml) 22.9 ± 10.0 23.1 ± 10.0 
Energy intake (kcal/day) 2,927 ± 1,148 2,909 ± 1,030 
Placebo + lifestyleOrlistat + lifestyle
n 1,637 1,640 
Sex (n [%])   
 Female 905 (55.3) 905 (55.2) 
 Male 732 (44.7) 735 (44.8) 
Age (years) 43.7 ± 8.0 43.0 ± 8.0 
Weight (kg) 110.6 ± 16.5 110.4 ± 16.3 
BMI (kg/m237.4 ± 4.5 37.3 ± 4.2 
Waist circumference (cm) 115.4 ± 10.4 115.0 ± 10.4 
IGT patients (n [%]) 344 (21) 350 (21.3) 
Whole blood glucose   
 Fasting (mmol/l) 4.6 ± 0.6 4.6 ± 0.6 
 2 h (mmol/l) 5.5 ± 1.6 5.5 ± 1.6 
 AUC (mmol · min−1 · l−1799 ± 179 804 ± 175 
Serum insulin   
 Fasting (pmol/l) 83.6 ± 47.2 86.1 ± 50.1 
 2 h (pmol/l) 344.9 ± 298.5 370.9 ± 336.7 
 AUC (nmol · min−1 · l−147.7 ± 28.4 49.7 ± 31.3 
Diastolic BP (mmHg) 82.3 ± 10.0 82.0 ± 10.0 
Systolic BP (mmHg) 130.4 ± 15.4 130.8 ± 15.8 
Total cholesterol (mmol/l) 5.8 ± 1.0 5.8 ± 1.0 
LDL cholesterol (mmol/l) 3.8 ± 0.9 3.7 ± 0.9 
HDL cholesterol (mmol/l) 1.2 ± 0.3 1.2 ± 0.3 
LDL-to-HDL ratio 3.3 ± 1.0 3.2 ± 1.1 
Triglycerides (mmol/l) 1.9 ± 1.2 1.9 ± 1.0 
Fibrinogen (μmol/l) 11.7 ± 2.0 11.7 ± 2.2 
Plasminogen activator inhibitor-1 (U/ml) 22.9 ± 10.0 23.1 ± 10.0 
Energy intake (kcal/day) 2,927 ± 1,148 2,909 ± 1,030 

Data are means ± SD, unless otherwise noted. AUC, area under the curve, BP, blood pressure.

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