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Table 3—

Oral symptomatic therapy of painful neuropathy

Drug classDrugDaily dose (mg)NNTNNHSide effects
Tricyclics Amitriptyline 25–150 2.4 (2.0–3.0) 2.7 (2.1–3.9) ++++ 
 Imipramine 25–150 2.4 (2.0–3.0) 2.7 (2.1–3.9) ++++ 
SSRIs Paroxetine 40 ND ND +++ 
 Citalopram 40 ND ND +++ 
Anticonvulsants Gabapentin 900–1,800 3.7 (2.4–8.3) 2.7 (2.2–3.4) ++ 
 Pregabalin 150–600 3.3 (2.3–5.9) 3.7 ++ 
 Carbamazepine 200–400 3.3 (2.0–9.4) 1.9 (1.4–2.8) +++ 
 Topiramate Up to 400 3.0 (2.3–4.5) 9.0 ++ 
Opioids Tramadol 50–400 3.4 (2.3–6.4) 7.8 +++ 
 Oxycodone CR 10–60 ND ND ++++ 
Drug classDrugDaily dose (mg)NNTNNHSide effects
Tricyclics Amitriptyline 25–150 2.4 (2.0–3.0) 2.7 (2.1–3.9) ++++ 
 Imipramine 25–150 2.4 (2.0–3.0) 2.7 (2.1–3.9) ++++ 
SSRIs Paroxetine 40 ND ND +++ 
 Citalopram 40 ND ND +++ 
Anticonvulsants Gabapentin 900–1,800 3.7 (2.4–8.3) 2.7 (2.2–3.4) ++ 
 Pregabalin 150–600 3.3 (2.3–5.9) 3.7 ++ 
 Carbamazepine 200–400 3.3 (2.0–9.4) 1.9 (1.4–2.8) +++ 
 Topiramate Up to 400 3.0 (2.3–4.5) 9.0 ++ 
Opioids Tramadol 50–400 3.4 (2.3–6.4) 7.8 +++ 
 Oxycodone CR 10–60 ND ND ++++ 

Data are median (range) unless otherwise indicated. See refs. 2, 19, and 20. ND, not determined; NNH, number needed to treat to harm one patient; NNT, number needed to treat to achieve pain relief in one patient; SSRI, selective serotonin reuptake inhibitor.

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