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Table 1—

Mean pharmacodynamic summary measures of 6 mg INH, subcutaneous injection of 18 U RHI, and subcutaneous injection of 18 U ILP on three different study days in 17 healthy volunteers (baseline values subtracted)

Serum glucose measuresINH (A)ILP (B)RHI (C)Ratio/difference90% CIP values*
Time to early half-maximal effect 32 41 48 −17 (A−C) −24 to −10 <0.001 
(tGIRearly 50%) (min)    −10 (A−B) −17 to −3 <0.05 
    −7 (B−C) −14 to 0 NS 
Maximal metabolic effect (GIRmax8.7 11.2 9.8 89% (A/C) 79–101 NS 
(mg · kg–1 · min−1)    78% (A/B) 69–88 <0.01 
    115% (B/C) 101–130 NS 
Time to maximal effect (tGIRmax143 137 193 −49 (A−C) −77 to −21 <0.01 
(min)     7 (A−B) −22 to 35 NS 
    −56 (B−C) −84 to −28 <0.01 
Time to late half-maximal effect 387 313 415 −29 (A−C) −71 to 13 NS 
(tGIRlate 50%) (min)    74 (A−B) 32–116 <0.01 
    −103 (B−C) −145 to −61 <0.001 
AUC-GIR0–60 (g/kg) 0.23 0.24 0.17 134% (A/C) 107–168 <0.05 
    96% (A/B) 76–120 NS 
    140% (B/C) 112–176 <0.05 
AUC-GIR0–180 (g/kg) 1.21 1.45 1.17 103% (A/C) 90–119 NS 
    84% (A/B) 73–96 <0.05 
    124% (B/C) 108–142 <0.05 
AUC-GIR0–600 (g/kg) 3.03 3.16 3.44 88% (A/C) 77–101 NS 
    96% (A/B) 84–110 NS 
    92% (B/C) 80–105 NS 
Serum glucose measuresINH (A)ILP (B)RHI (C)Ratio/difference90% CIP values*
Time to early half-maximal effect 32 41 48 −17 (A−C) −24 to −10 <0.001 
(tGIRearly 50%) (min)    −10 (A−B) −17 to −3 <0.05 
    −7 (B−C) −14 to 0 NS 
Maximal metabolic effect (GIRmax8.7 11.2 9.8 89% (A/C) 79–101 NS 
(mg · kg–1 · min−1)    78% (A/B) 69–88 <0.01 
    115% (B/C) 101–130 NS 
Time to maximal effect (tGIRmax143 137 193 −49 (A−C) −77 to −21 <0.01 
(min)     7 (A−B) −22 to 35 NS 
    −56 (B−C) −84 to −28 <0.01 
Time to late half-maximal effect 387 313 415 −29 (A−C) −71 to 13 NS 
(tGIRlate 50%) (min)    74 (A−B) 32–116 <0.01 
    −103 (B−C) −145 to −61 <0.001 
AUC-GIR0–60 (g/kg) 0.23 0.24 0.17 134% (A/C) 107–168 <0.05 
    96% (A/B) 76–120 NS 
    140% (B/C) 112–176 <0.05 
AUC-GIR0–180 (g/kg) 1.21 1.45 1.17 103% (A/C) 90–119 NS 
    84% (A/B) 73–96 <0.05 
    124% (B/C) 108–142 <0.05 
AUC-GIR0–600 (g/kg) 3.03 3.16 3.44 88% (A/C) 77–101 NS 
    96% (A/B) 84–110 NS 
    92% (B/C) 80–105 NS 
*

One-sided for tGIRmax and AUC-GIR0–60; two-sided for all other measures;

arithmetic mean;

geometric mean.

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