Serum glucose measures . | INH (A) . | ILP (B) . | RHI (C) . | Ratio/difference . | 90% CI . | P values^{*}
. |
---|---|---|---|---|---|---|

Time to early half-maximal effect | 32 | 41 | 48 | −17 (A−C) | −24 to −10 | <0.001 |

(t_{GIR}_{early 50%}) (min)^{†} | −10 (A−B) | −17 to −3 | <0.05 | |||

−7 (B−C) | −14 to 0 | NS | ||||

Maximal metabolic effect (GIR_{max}) | 8.7 | 11.2 | 9.8 | 89% (A/C) | 79–101 | NS |

(mg · kg^{–1} · min^{−1})^{‡} | 78% (A/B) | 69–88 | <0.01 | |||

115% (B/C) | 101–130 | NS | ||||

Time to maximal effect (t_{GIRmax}) | 143 | 137 | 193 | −49 (A−C) | −77 to −21 | <0.01 |

(min) ^{†} | 7 (A−B) | −22 to 35 | NS | |||

−56 (B−C) | −84 to −28 | <0.01 | ||||

Time to late half-maximal effect | 387 | 313 | 415 | −29 (A−C) | −71 to 13 | NS |

(t_{GIR}_{late 50%}) (min)^{†} | 74 (A−B) | 32–116 | <0.01 | |||

−103 (B−C) | −145 to −61 | <0.001 | ||||

AUC-GIR_{0–60} (g/kg)^{‡} | 0.23 | 0.24 | 0.17 | 134% (A/C) | 107–168 | <0.05 |

96% (A/B) | 76–120 | NS | ||||

140% (B/C) | 112–176 | <0.05 | ||||

AUC-GIR_{0–180} (g/kg)^{‡} | 1.21 | 1.45 | 1.17 | 103% (A/C) | 90–119 | NS |

84% (A/B) | 73–96 | <0.05 | ||||

124% (B/C) | 108–142 | <0.05 | ||||

AUC-GIR_{0–600} (g/kg)^{‡} | 3.03 | 3.16 | 3.44 | 88% (A/C) | 77–101 | NS |

96% (A/B) | 84–110 | NS | ||||

92% (B/C) | 80–105 | NS |

Serum glucose measures . | INH (A) . | ILP (B) . | RHI (C) . | Ratio/difference . | 90% CI . | P values^{*}
. |
---|---|---|---|---|---|---|

Time to early half-maximal effect | 32 | 41 | 48 | −17 (A−C) | −24 to −10 | <0.001 |

(t_{GIR}_{early 50%}) (min)^{†} | −10 (A−B) | −17 to −3 | <0.05 | |||

−7 (B−C) | −14 to 0 | NS | ||||

Maximal metabolic effect (GIR_{max}) | 8.7 | 11.2 | 9.8 | 89% (A/C) | 79–101 | NS |

(mg · kg^{–1} · min^{−1})^{‡} | 78% (A/B) | 69–88 | <0.01 | |||

115% (B/C) | 101–130 | NS | ||||

Time to maximal effect (t_{GIRmax}) | 143 | 137 | 193 | −49 (A−C) | −77 to −21 | <0.01 |

(min) ^{†} | 7 (A−B) | −22 to 35 | NS | |||

−56 (B−C) | −84 to −28 | <0.01 | ||||

Time to late half-maximal effect | 387 | 313 | 415 | −29 (A−C) | −71 to 13 | NS |

(t_{GIR}_{late 50%}) (min)^{†} | 74 (A−B) | 32–116 | <0.01 | |||

−103 (B−C) | −145 to −61 | <0.001 | ||||

AUC-GIR_{0–60} (g/kg)^{‡} | 0.23 | 0.24 | 0.17 | 134% (A/C) | 107–168 | <0.05 |

96% (A/B) | 76–120 | NS | ||||

140% (B/C) | 112–176 | <0.05 | ||||

AUC-GIR_{0–180} (g/kg)^{‡} | 1.21 | 1.45 | 1.17 | 103% (A/C) | 90–119 | NS |

84% (A/B) | 73–96 | <0.05 | ||||

124% (B/C) | 108–142 | <0.05 | ||||

AUC-GIR_{0–600} (g/kg)^{‡} | 3.03 | 3.16 | 3.44 | 88% (A/C) | 77–101 | NS |

96% (A/B) | 84–110 | NS | ||||

92% (B/C) | 80–105 | NS |

*

One-sided for *t*_{GIRmax} and AUC-GIR_{0–60}; two-sided for all other measures;

†

arithmetic mean;

‡

geometric mean.

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